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    Immortal Pluripotent Stem Cell Line, Cell Lines Derived Therefrom, Methods of Preparing Thereof and Their Uses
    2.
    发明申请
    Immortal Pluripotent Stem Cell Line, Cell Lines Derived Therefrom, Methods of Preparing Thereof and Their Uses 审中-公开
    不朽多能干细胞系，其衍生的细胞系，其制备方法及其用途

    公开(公告)号：US20080311625A1

    公开(公告)日：2008-12-18

    申请号：US12094147

    申请日：2006-11-16

    申请人： Luisa Gennero ,  Antonio Ponzetto ,  Andrea Savarino

    发明人： Luisa Gennero ,  Antonio Ponzetto ,  Andrea Savarino

    IPC分类号： C12P21/04 ,  C12N5/08

    CPC分类号： C12N5/0694 ,  C12N5/067 ,  C12N2501/01 ,  C12N2501/12 ,  C12N2501/23 ,  C12N2501/235 ,  C12N2506/11 ,  C12N2506/30

    摘要： The present invention relates to immortal pluripotent stem cells derived from a human leukaemia cell line, preferably a human monocytoid cell line and more preferably the human monocytoid cell line, THP1. The present invention further relates to cell lines derived from the immortal pluripotent stem cell line having the phenotype of cell strains characteristic of human tissues, particularly having a human hepatocyte phenotype, as well as the methods for preparing thereof. The present invention further relates to the use of the derived cell line with a human hepatocytic phenotype for the production of albumin and blood coagulation factors.

    摘要翻译： 本发明涉及源自人白血病细胞系，优选人单核细胞系细胞系，更优选人单核细胞增生细胞系THP1的永生多能干细胞。 本发明还涉及源自具有人组织，特别是人肝细胞表型特征的细胞株表型的永生多能干细胞系的细胞系及其制备方法。 本发明还涉及具有人肝细胞表型的衍生细胞系用于产生白蛋白和凝血因子的用途。

    METHOD FOR DEFINING A PERSONALIZED VACCINE AGAINST HIV/AIDS
    4.
    发明申请
    METHOD FOR DEFINING A PERSONALIZED VACCINE AGAINST HIV/AIDS 有权

    公开(公告)号：US20220111036A1

    公开(公告)日：2022-04-14

    申请号：US17547350

    申请日：2021-12-10

    申请人： Ricardo Diaz ,  Andrea Savarino ,  Iart Shytaj

    发明人： Ricardo Diaz ,  Andrea Savarino ,  Iart Shytaj

    IPC分类号： A61K39/21 ,  A61K31/455 ,  A61K31/7135 ,  A61P31/18

    摘要： A novel approach to the development of a personalized vaccine. This approach is based on: A) sequencing of the gag gene from an HIV-infected individual treated with antiretroviral therapy; B) sequencing of the HLA alleles of the same individual; C) selecting the epitopes recognized by the individual's own HLA Class I within the highly-conserved Gag256-377, Gag147-169 and/or Gag225-251 amino acid sequences. An original algorithm that designs the target peptide for the vaccine starting from viral and HLA sequences of an individual with HIV/AIDS, forms the core of the present invention. The original algorithm makes extensive use of existing open- source software for protein design. The peptides designed in this manner and accordingly synthesized may be exploited as a therapeutic vaccine against HIV/AIDS. Vehicles for such peptides may be an individual's own dendritic cells pulsed with the peptide combination or a specific viral or DNA vector leading to intracellular expression of the viral peptides. The present vaccine approach may contribute to control of viremia once antiretroviral therapies are suspended.

    TREATMENT OF RETROVIRAL RESERVOIRS EXPLOITING OXIDATIVE STRESS
    5.
    发明申请
    TREATMENT OF RETROVIRAL RESERVOIRS EXPLOITING OXIDATIVE STRESS 有权
    治疗开发氧化应激的替代储备

    公开(公告)号：US20110305774A1

    公开(公告)日：2011-12-15

    申请号：US13125325

    申请日：2009-10-29

    申请人： Andrea Savarino ,  Marina Lusic ,  Antonello Mai ,  Anna Teresa Palamara ,  Enrico Garaci

    发明人： Andrea Savarino ,  Marina Lusic ,  Antonello Mai ,  Anna Teresa Palamara ,  Enrico Garaci

    IPC分类号： A61K33/36 ,  A61K33/26 ,  A61K31/197 ,  A61K31/4406 ,  C12N5/0783 ,  A61P31/14 ,  A61P31/18 ,  C12N5/071 ,  C12N5/0786 ,  A61K31/7135 ,  A61K31/513

    CPC分类号： A61K33/36 ,  A61K31/167 ,  A61K31/198 ,  A61K31/28 ,  A61K31/295 ,  A61K31/4406 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7024 ,  A61K33/04 ,  A61K33/26 ,  A61K45/06 ,  A61K2300/00

    摘要： Activation of HIV-1 replication causes oxidative stress, which in turn potentiates HIV-1 replication. The common basis for the compounds of the present invention is: A) the capacity of reactivating HIV-1 from latency, and B) the ability to counteract the cellular machinery which activates in order to limit the effects of oxidative stress. In this way, oxidative stress can be potentiated and a “chain reaction” is sparked. This “chain reaction” induces a more efficient reactivation of HIV-1 from latency and, in some cases, induces selective killing of the infected cells. Actions A) and B) can either be carried out by one drug exerting both effects, or obtained by the combined use of distinct drugs. There are two main cellular machineries counteracting oxidative stress, i.e. the thioredoxin (Trx) thioredoxin reductase (TrxR) system and glutathione. Herein, we present drug strategies capable of exerting action B) by blocking either of the two machineries.

    摘要翻译： HIV-1复制的激活导致氧化应激，这反过来加强了HIV-1的复制。 本发明化合物的共同基础是：A）从潜伏期重新激活HIV-1的能力，以及B）抵抗激活以抑制氧化应激作用的细胞机制的能力。 以这种方式，可以增强氧化应激，引发“连锁反应”。 这种“连锁反应”诱导HIV-1从潜伏期更有效的再活化，并且在某些情况下诱导对感染细胞的选择性杀伤。 动作A）和B）可以由一种既能发挥作用的药物也可以通过组合使用不同药物而获得。 有两个主要的细胞机制抵消氧化应激，即硫氧还蛋白（Trx）硫氧还蛋白还原酶（TrxR）系统和谷胱甘肽。 在这里，我们提出能够通过阻止两个机器中的任何一个来施加动作B）的药物策略。

    Treatment of retroviral reservoirs exploiting oxidative stress
    6.
    发明授权
    Treatment of retroviral reservoirs exploiting oxidative stress 有权
    治疗逆转录病毒储库利用氧化应激

    公开(公告)号：US08785493B2

    公开(公告)日：2014-07-22

    申请号：US13125325

    申请日：2009-10-29

    申请人： Andrea Savarino ,  Antonello Mai ,  Anna Teresa Palamara ,  Enrico Garaci

    发明人： Andrea Savarino ,  Antonello Mai ,  Anna Teresa Palamara ,  Enrico Garaci

    IPC分类号： A61K31/28 ,  A61K31/70 ,  A61K33/24

    CPC分类号： A61K33/36 ,  A61K31/167 ,  A61K31/198 ,  A61K31/28 ,  A61K31/295 ,  A61K31/4406 ,  A61K31/513 ,  A61K31/555 ,  A61K31/7024 ,  A61K33/04 ,  A61K33/26 ,  A61K45/06 ,  A61K2300/00

    摘要： Activation of HIV-1 replication causes oxidative stress, which in turn potentiates HIV-1 replication. The common basis for the compounds of the present invention is: A) the capacity of reactivating HIV-1 from latency, and B) the ability to counteract the cellular machinery which activates in order to limit the effects of oxidative stress. In this way, oxidative stress can be potentiated and a “chain reaction” is sparked. This “chain reaction” induces a more efficient reactivation of HIV-1 from latency and, in some cases, induces selective killing of the infected cells. Actions A) and B) can either be carried out by one drug exerting both effects, or obtained by the combined use of distinct drugs. There are two main cellular machineries counteracting oxidative stress, i.e. the thioredoxin (Trx) thioredoxin reductase (TrxR) system and glutathione. Herein, we present drug strategies capable of exerting action B) by blocking either of the two machineries.

    摘要翻译： HIV-1复制的激活导致氧化应激，这反过来加强了HIV-1的复制。 本发明化合物的共同基础是：A）从潜伏期重新激活HIV-1的能力，以及B）抵抗激活以抑制氧化应激作用的细胞机制的能力。 以这种方式，可以增强氧化应激，引发“连锁反应”。 这种“连锁反应”诱导HIV-1从潜伏期更有效的再活化，并且在某些情况下诱导对感染细胞的选择性杀伤。 动作A）和B）可以由一种既能发挥作用的药物也可以通过组合使用不同药物而获得。 有两个主要的细胞机制抵消氧化应激，即硫氧还蛋白（Trx）硫氧还蛋白还原酶（TrxR）系统和谷胱甘肽。 在这里，我们提出能够通过阻止两个机器中的任何一个来施加动作B）的药物策略。

    COMPOSITIONS CONTAINING ANTI-HIV PEPTIDES AND METHODS FOR USE
    7.
    发明申请
    COMPOSITIONS CONTAINING ANTI-HIV PEPTIDES AND METHODS FOR USE 失效
    含有抗HIV肽的组合物和使用方法

    公开(公告)号：US20090170764A1

    公开(公告)日：2009-07-02

    申请号：US12098094

    申请日：2008-04-04

    申请人： Andrea Savarino ,  Umberto Dianzani

    发明人： Andrea Savarino ,  Umberto Dianzani

    IPC分类号： A61K38/10 ,  A61K38/17 ,  A61K38/08

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen are provided which may be used to inhibit or prevent transmission or replication of the HIV virus. The peptides have from 13 to 30 amino acids and include the amino acid sequence GPGTTK (SEQ ID for topical application to inhibit or prevent transmission of the HIV virus.

    摘要翻译： 提供了代表人CD38白细胞表面抗原区域45-74的序列的肽，其可用于抑制或预防HIV病毒的传播或复制。 肽具有13至30个氨基酸，并且包括氨基酸序列GPGTTK（用于局部应用的SEQ ID，用于抑制或预防HIV病毒的传播。

    Microbicidal compositions comprising human CD38 polypeptides derived from the extracellular membrane-proximal region
    9.
    发明授权
    Microbicidal compositions comprising human CD38 polypeptides derived from the extracellular membrane-proximal region 失效
    包含衍生自细胞外膜近端区域的人CD38多肽的杀微生物组合物

    公开(公告)号：US08030444B2

    公开(公告)日：2011-10-04

    申请号：US12184409

    申请日：2008-08-01

    申请人： Andrea Savarino ,  Umberto Dianzani

    发明人： Andrea Savarino ,  Umberto Dianzani

    IPC分类号： A61K38/00 ,  A61K38/04

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： Peptides representing sequences from region 45-74 of the human CD38 leukocyte surface antigen (SEQ ID NO:1) are provided which may be used to inhibit or prevent transmission or replication of the HIV virus. The peptides have from 13 to 30 amino acids and include the amino acid sequence GPGTTK (SEQ ID NO:18) for topical application to inhibit or prevent transmission of the HIV virus.

    摘要翻译： 提供表示人CD38白细胞表面抗原（SEQ ID NO：1）区域45-74的序列的肽，其可用于抑制或预防HIV病毒的传播或复制。 肽具有13至30个氨基酸，并且包括用于局部应用以抑制或预防HIV病毒传播的氨基酸序列GPGTTK（SEQ ID NO：18）。

    Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors
    10.
    发明授权
    Methods for treatment of HIV or malaria using combinations of chloroquine and protease inhibitors 失效
    使用氯喹和蛋白酶抑制剂的组合治疗HIV或疟疾的方法

    公开(公告)号：US07553844B2

    公开(公告)日：2009-06-30

    申请号：US10783268

    申请日：2004-02-20

    申请人： Andrea Savarino

    发明人： Andrea Savarino

    IPC分类号： A61K31/00 ,  A61K9/14

    CPC分类号： A61K31/427 ,  A61K31/47 ,  A61K31/4706 ,  A61K31/4725 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/551 ,  A61K45/06 ,  Y02A50/411 ,  A61K2300/00

    摘要： The present invention relates to a drug combination capable of conferring therapeutic benefits in the treatment of both AIDS and malaria. In particular, it relates to a drug combination including at least one quinolinic antimalarial compound such as chloroquine or hydroxychloroquine, and at least one inhibitor of the Human Immunodeficiency Virus (HIV) protease enzyme. This drug combination is capable of inhibiting the replication of both HIV and Plasmodium sp. It also relates to the direct antimalarial effects of the HIV PIs.

    摘要翻译： 本发明涉及一种能够在治疗艾滋病和疟疾方面赋予治疗益处的药物组合。 特别地，本发明涉及包含至少一种喹啉类抗疟药化合物如氯喹或羟氯喹的药物组合和至少一种人免疫缺陷病毒（HIV）蛋白酶抑制剂。 这种药物组合能够抑制HIV和疟原虫的复制。 它也涉及HIV PI的直接抗疟作用。