发明申请
US20110045519A1 DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF
审中-公开
可生产ALBUMIN和血液凝血因子的差异化的免疫细胞系，其从LEUKEMIA细胞系制备的方法及其用途
- 专利标题： DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF
- 专利标题（中）： 可生产ALBUMIN和血液凝血因子的差异化的免疫细胞系，其从LEUKEMIA细胞系制备的方法及其用途
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申请号： US12521517申请日： 2007-12-21
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公开(公告)号： US20110045519A1公开(公告)日： 2011-02-24
- 发明人: Luisa Gennero , Antonio Ponzetto , Giampiero Pescarmona , Andrea Savarino , Gianfranco Merizzi
- 申请人： Luisa Gennero , Antonio Ponzetto , Giampiero Pescarmona , Andrea Savarino , Gianfranco Merizzi
- 优先权： ITTO2006A000937 20061229
- 国际申请： PCT/IB2007/055287 WO 20071221
- 主分类号： C12N5/071
- IPC分类号： C12N5/071 ; C12N5/22 ; C12P21/00 ; C12Q1/02
摘要：
The invention relates to cell lines from differentiated cells with hepatocytic phenotypes capable of producing albumin and blood coagulation factors, said cells being derived from a human leukaemia cell line, preferably the human THP1 cell line, and preserving the characteristics of immortality. Among the cell lines of the invention, the cell lines known as PSC-THP1-EP, PSC-THP1-EP-FAST, PSC-THP1-HEP and PSC-THP1-EPEP are preferred. The invention also relates to methods for obtaining the cell lines of the invention and the uses of said cell lines, particularly for the production of albumin and/or blood coagulation factors.
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