公开(公告)号：US12241105B2

公开(公告)日：2025-03-04

申请号：US17813240

申请日：2022-07-18

Applicant: LanzaTech, Inc.

Inventor： Nicholas Alexander Fackler ,  Sean Dennis Simpson ,  Michael Koepke ,  Stephanie Rhianon Jones

IPC: C12P19/34 ,  C12N1/20 ,  C12N1/32 ,  C12P7/04 ,  G16B5/10 ,  G16B20/50

Abstract: The disclosure provides genetically engineered C1-fixing microorganisms capable of producing nanobodies. Additionally, the disclosure provides engineered microorganisms comprising one or more disrupted genes to strategically divert carbon flux away from nonessential or undesirable products towards products and/or co-products of interest. The disclosure enables co-production of useful chemicals from gaseous substrates.

公开(公告)号：US12234492B2

公开(公告)日：2025-02-25

申请号：US17150900

申请日：2021-01-15

Applicant: LanzaTech, Inc.

Inventor： Fungmin Liew ,  Michael Koepke ,  Shilpa Nagaraju ,  Audrey Harris

IPC: C12N9/88 ,  C12N9/02 ,  C12N9/04 ,  C12N9/06 ,  C12N9/10 ,  C12N9/12 ,  C12N9/90 ,  C12P7/22

Abstract: Disclosed herein are improved methods for production of 2-phenylethanol by microbial fermentation of substrates comprising carbon monoxide and/or carbon dioxide and further disclosed are genetically modified microorganisms for use in such methods that alleviate dependence on natural and petrochemical processes.

公开(公告)号：US20230050887A1

公开(公告)日：2023-02-16

申请号：US17813274

申请日：2022-07-18

Applicant: LanzaTech, Inc.

Inventor： Nicholas Alexander Fackler ,  Sean Dennis Simpson ,  Michael Koepke ,  Stephanie Rhianon Jones

IPC: C12N15/117 ,  C12N15/74

Abstract: The disclosure provides genetically engineered microorganisms capable of producing antigen-binding molecules. Additionally, the disclosure provides engineered microorganisms comprising one or more disrupted genes to strategically divert carbon flux away from undesirable products towards products, and optionally co-products, of interest. Further, the disclosure enables co-production of useful chemicals from gaseous substrates.

公开(公告)号：US12157908B2

公开(公告)日：2024-12-03

申请号：US16800844

申请日：2020-02-25

Applicant: Northwestern University ,  LanzaTech, Inc.

Inventor： Michael Christopher Jewett ,  Antje Kruger-Gericke ,  Alexander Paul Mueller ,  Michael Koepke

IPC: C12P21/00 ,  C12N1/20 ,  C12N9/12 ,  C12N15/10

Abstract: Disclosed are compositions, methods, and kits for performing cell-free RNA transcription and/or cell-free protein synthesis (CFPS). The disclosed compositions, methods, and kits include or utilize components prepared from a species of Clostridia such as cellular extracts from Clostridium autoethanogenum.

公开(公告)号：US20230407346A1

公开(公告)日：2023-12-21

申请号：US18456894

申请日：2023-08-28

Applicant: LanzaTech, Inc.

Inventor： Sean Dennis Simpson ,  Allan Haiming Gao ,  Robert John Conrado ,  James Daniel Winkler ,  Alexander Paul Mueller ,  Steven Brown ,  Loan Phuong Tran ,  Michael Koepke ,  Christophe Daniel Mihalcea

IPC: C12P7/04

CPC classification number: C12P7/04 ,  C12P39/00

Abstract: The disclosure relates to the system comprising a combination of a primary bioreactor with a secondary bioreactor to convert a gaseous stream comprising CO and optionally H2, or CO2 and H2 to at least one target product. Bioreactors may be any combination of aerobic and anaerobic, batch and continuous. The bioreactors comprise fermenting microorganisms that may typically be bacterial or fungal.

公开(公告)号：US20250059146A1

公开(公告)日：2025-02-20

申请号：US18938061

申请日：2024-11-05

Applicant: LanzaTech, Inc.

Inventor： Jennifer Rosa Holmgren ,  Sean Dennis Simpson ,  Michael Koepke ,  Robert John Conrado ,  Ralph Dwayne Gillespie

IPC: C07D303/04 ,  C07C1/24 ,  C07C29/152 ,  C08G63/183 ,  C08G63/78 ,  C12P5/02 ,  C12P7/04 ,  C12P7/06

Abstract: The disclosure relates to methods of capturing carbon by microbial fermentation of a gaseous substrate comprising CO into one or more first products which, in turn, may be incorporated into an article of manufacture or one or more second products. Further, the disclosure relates to improving carbon capture and/or efficiency.

公开(公告)号：US20250027121A1

公开(公告)日：2025-01-23

申请号：US18770533

申请日：2024-07-11

Applicant: LanzaTech, Inc.

Inventor： Sean Dennis Simpson ,  Michael Koepke ,  James MacAllister Clomburg ,  Juniper Dee Gramling ,  Stephanie Rhianon Jones ,  Jaeyoung Jung ,  Timothy James Politano ,  Ryan Christopher Tappel

IPC: C12P7/6409 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10 ,  C12N9/18

Abstract: Microorganisms are genetically engineered to continuously produce fatty acids, fatty alcohols, cultured protein, or any combination thereof by microbial fermentation, particularly by microbial fermentation of a gaseous substrate. The microorganisms are C1-fixing. The production of fatty acids, fatty alcohols, and cultured proteins can be improved. This can be improved by varying promoters or nutrient limiting means.

公开(公告)号：US11952607B2

公开(公告)日：2024-04-09

申请号：US17817766

申请日：2022-08-05

Applicant: LanzaTech, Inc.

Inventor： Zachary Robert Cowden ,  Ching Leang ,  Michael Koepke ,  Rasmus Overgaard Jensen ,  Alexander Paul Mueller

IPC: C12N15/74 ,  C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/52 ,  C12P7/18 ,  C12R1/145

CPC classification number: C12P7/18 ,  C12N1/20 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12R2001/145 ,  C12Y102/01003 ,  C12Y102/01021 ,  C12Y203/03001 ,  C12Y206/01044 ,  C12Y401/03001

Abstract: The disclosure provides genetically engineered microorganisms and methods for improved biological production of ethylene glycol and precursors of ethylene glycol. The microorganism of the disclosure produces ethylene glycol or a precursor of ethylene glycol through one or more of 5,10-methylenetetrahydrofolate, oxaloacetate, citrate, malate, and glycine. The disclosure further provides compositions comprising ethylene glycol or polymers of ethylene glycol such as polyethylene terephthalate.

公开(公告)号：US11788092B2

公开(公告)日：2023-10-17

申请号：US17650191

申请日：2022-02-07

Applicant: LanzaTech, Inc.

Inventor： Fungmin Liew ,  Michael Koepke

IPC: C12N15/52 ,  C12N15/74 ,  C12P7/42 ,  C12P7/18 ,  C12N9/00 ,  C12N9/02 ,  C12N9/04 ,  C12N9/10

CPC classification number: C12N15/52 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/1096 ,  C12N9/93 ,  C12N15/74 ,  C12P7/18 ,  C12P7/42 ,  C12Y101/01001 ,  C12Y102/01075 ,  C12Y102/07005 ,  C12Y206/01018 ,  C12Y604/01002

Abstract: Microorganisms are genetically engineered to produce 3-hydroxypropionate (3-HP). The microorganisms are carboxydotrophic acetogens. The microorganisms produce acetyl-coA using the Wood-Ljungdahl pathway for fixing CO/CO2. A β-alanine pyruvate aminotransferase from a microorganism that contains such an enzyme is introduced. Additionally, an acetyl-coA carboxylase may also be introduced. The production of 3-HP can be improved. This can be effected by improved promoters or higher copy number or enzymes that are catalytically more efficient.

公开(公告)号：US20210292732A1

公开(公告)日：2021-09-23

申请号：US17150900

申请日：2021-01-15

Applicant: LanzaTech, Inc.

Inventor： Fungmin Liew ,  Michael Koepke ,  Shilpa Nagaraju ,  Audrey Harris

IPC: C12N9/88 ,  C12N9/06 ,  C12N9/02 ,  C12N9/12 ,  C12N9/10 ,  C12N9/04 ,  C12N9/90 ,  C12P7/22

Abstract: Disclosed herein are methods for production of 2-phenylethanol by microbial fermentation of substrates comprising carbon monoxide and/or carbon dioxide and further disclosed are genetically modified microorganisms for use in such methods. Additionally, the processes disclosed herein are improved methods of 2-PE production that alleviate dependence on natural and petrochemical processes.