公开(公告)号：US11999982B2

公开(公告)日：2024-06-04

申请号：US18004364

申请日：2021-06-28

申请人： Evonik Operations GmbH

发明人： Frank Schneider ,  Frank Jankowitsch

IPC分类号： C12P13/00 ,  C12N1/21 ,  C12N9/10 ,  C12N15/52

CPC分类号： C12P13/00 ,  C12N9/1003 ,  C12N9/1022 ,  C12N9/1096 ,  C12N15/52 ,  C12Y201/04001 ,  C12Y203/03009 ,  C12Y206/01002 ,  C12Y206/01004 ,  C12Y206/01044

摘要： A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.

公开(公告)号：US12065677B2

公开(公告)日：2024-08-20

申请号：US18004327

申请日：2021-06-28

申请人： Evonik Operations GmbH

发明人： Frank Schneider ,  Frank Jankowitsch

IPC分类号： C12N9/10 ,  C12P13/04

CPC分类号： C12N9/1003 ,  C12N9/1096 ,  C12P13/04 ,  C12Y201/04001 ,  C12Y206/01002 ,  C12Y206/01004 ,  C12Y206/01044

摘要： A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.

公开(公告)号：US11952607B2

公开(公告)日：2024-04-09

申请号：US17817766

申请日：2022-08-05

申请人： LanzaTech, Inc.

发明人： Zachary Robert Cowden ,  Ching Leang ,  Michael Koepke ,  Rasmus Overgaard Jensen ,  Alexander Paul Mueller

IPC分类号： C12N15/74 ,  C12N1/20 ,  C12N9/02 ,  C12N9/10 ,  C12N9/88 ,  C12N15/52 ,  C12P7/18 ,  C12R1/145

CPC分类号： C12P7/18 ,  C12N1/20 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1096 ,  C12N9/88 ,  C12N15/52 ,  C12R2001/145 ,  C12Y102/01003 ,  C12Y102/01021 ,  C12Y203/03001 ,  C12Y206/01044 ,  C12Y401/03001

摘要： The disclosure provides genetically engineered microorganisms and methods for improved biological production of ethylene glycol and precursors of ethylene glycol. The microorganism of the disclosure produces ethylene glycol or a precursor of ethylene glycol through one or more of 5,10-methylenetetrahydrofolate, oxaloacetate, citrate, malate, and glycine. The disclosure further provides compositions comprising ethylene glycol or polymers of ethylene glycol such as polyethylene terephthalate.

公开(公告)号：US20190185888A1

公开(公告)日：2019-06-20

申请号：US16226603

申请日：2018-12-19

申请人： LanzaTech, Inc.

发明人： Michael Koepke ,  Rasmus Jensen

IPC分类号： C12P7/18 ,  C12N9/10 ,  C12N9/88 ,  C12N9/02

CPC分类号： C12P7/18 ,  C12N9/0008 ,  C12N9/1025 ,  C12N9/1096 ,  C12N9/88 ,  C12Y102/01003 ,  C12Y102/01021 ,  C12Y203/03001 ,  C12Y206/01044 ,  C12Y401/03001

摘要： The invention provides genetically engineered microorganisms and methods for the biological production of ethylene glycol and precursors of ethylene glycol. In particular, the microorganism of the invention produces ethylene glycol or a precursor of ethylene glycol through one or more of 5,10-methylenetetrahydrofolate, oxaloacetate, citrate, malate, and glycine. The invention further provides compositions comprising ethylene glycol or polymers of ethylene glycol such as polyethylene terephthalate.

公开(公告)号：US20230265471A1

公开(公告)日：2023-08-24

申请号：US18004364

申请日：2021-06-28

申请人： Evonik Operation GmbH

发明人： Frank Schneider ,  Frank Jankowitsch

IPC分类号： C12P13/00 ,  C12N9/10 ,  C12N15/52

CPC分类号： C12P13/00 ,  C12N9/1003 ,  C12N9/1022 ,  C12N9/1096 ,  C12N15/52 ,  C12Y201/04001 ,  C12Y203/03009 ,  C12Y206/01002 ,  C12Y206/01004 ,  C12Y206/01044

摘要： A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.

公开(公告)号：US20230227795A1

公开(公告)日：2023-07-20

申请号：US18004327

申请日：2021-06-28

申请人： Evonik Operations GmbH

发明人： Frank Schneider ,  Frank Jankowitsch

IPC分类号： C12P13/04 ,  C12N9/10

CPC分类号： C12P13/04 ,  C12N9/1003 ,  C12Y201/04001 ,  C12N9/1096 ,  C12Y206/01002 ,  C12Y206/01004 ,  C12Y206/01044

摘要： A microorganism is transformed to be capable of producing guanidinoacetic acid (GAA). A method can be used for the fermentative production of GAA using such a microorganism. A corresponding method can be used for the fermentative production of creatine.

公开(公告)号：US20230183706A1

公开(公告)日：2023-06-15

申请号：US17945151

申请日：2022-09-15

申请人： Alnylam Pharmaceuticals, Inc.

发明人： Aimee M. Deaton ,  David Erbe

IPC分类号： C12N15/113 ,  C12N9/10 ,  A61P13/04

CPC分类号： C12N15/1137 ,  C12Y101/01027 ,  C12Y101/03015 ,  C12N9/1096 ,  C12Y206/01044 ,  A61P13/04 ,  C12N2310/11 ,  C12N2310/315

摘要： The present invention provides methods for treating subjects suffering from a kidney stone disease carrying a heterozygous AGXT gene variant, methods for identifying such subjects, and compositions comprising nucleic acid inhibitors, e.g., double stranded ribonucleic acid (dsRNA) agents or single stranded antisense polynucleotide agents targeting lactate dehydrogenase A (LDHA) and/or hydroxyacid oxidase (HAO1), for treating such subjects.