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公开(公告)号：US20250043342A1
公开(公告)日：2025-02-06
申请号：US18920456
申请日：2024-10-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US20240309443A1
公开(公告)日：2024-09-19
申请号：US18407234
申请日：2024-01-08
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Philip WAGGONER , James A. BALL , Michael L. MINTO , David M. COX , Wolfgang HINZ , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Scott PARKER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
CPC classification number: C12Q1/6869 , G01N27/4145
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US20160258011A1
公开(公告)日：2016-09-08
申请号：US15061273
申请日：2016-03-04
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Phil WAGGONER , James A. BALL , Wolfgang HINZ , Michael L. MINTO , Scott PARKER , David M. COX , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Kimberly GORRELL
IPC: C12Q1/68 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
Abstract translation: 传感器装置包括基板，设置在基板上的半导体器件，具有表面电极结构的半导体器件和形成在表面电极结构上的糖类涂层。 在使用前可以除去糖衣。 该半导体器件还可以包括一个阱以及可选地布置在阱中的珠。
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公开(公告)号：US20190071723A1
公开(公告)日：2019-03-07
申请号：US16182384
申请日：2018-11-06
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Phil WAGGONER , James A. BALL , Wolfgang HINZ , Michael L. MINTO , Scott PARKER , David M. COX , Alexander MASTROIANNI , Jeremy GRAY , Marc GLAZER , Kimberly GORRELL
IPC: C12Q1/6869 , G01N27/414
Abstract: A sensor apparatus includes a substrate, a semiconductor device disposed over the substrate, the semiconductor device having a surface electrode structure, and a saccharide coating formed over the surface electrode structure. The saccharide coating can be removed prior to use. The semiconductor device can further include a well and optionally a bead disposed in the well.
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公开(公告)号：US20160228877A1
公开(公告)日：2016-08-11
申请号：US15132404
申请日：2016-04-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： David M. COX
CPC classification number: B01L9/50 , B01L3/502 , B01L3/502715 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/12 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , F16M13/02 , Y10S439/912 , Y10T137/0402 , Y10T137/598 , Y10T137/6966
Abstract: A vertical clamping device is provided that supports a flow cell component in a vertical configuration in which the flow cell is on an opposite side of the vertical support from the electronic interface. The clamp includes a vertical setting to receive the flow cell component and provides an electronic interface on a vertical surface of the vertical setting. A block supports the fluidics interface and can move in a horizontal direction bringing the fluidics interface into contact with the flow cell component.
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Patent Agency Ranking
公开(公告)号：US20150328640A1
公开(公告)日：2015-11-19
申请号：US14810018
申请日：2015-07-27
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： David M. COX
IPC: B01L9/00
CPC classification number: B01L9/50 , B01L3/502 , B01L3/502715 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/12 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , F16M13/02 , Y10S439/912 , Y10T137/0402 , Y10T137/598 , Y10T137/6966
Abstract: A vertical clamping device is provided that supports a flow cell component in a vertical configuration in which the flow cell is on an opposite side of the vertical support from the electronic interface. The clamp includes a vertical setting to receive the flow cell component and provides an electronic interface on a vertical surface of the vertical setting. A block supports the fluidics interface and can move in a horizontal direction bringing the fluidics interface into contact with the flow cell component.
Abstract translation: 提供了一种垂直夹紧装置，其支撑垂直构造的流动池组件，其中流动池位于垂直支撑件与电子界面相反的一侧。 夹具包括垂直设置以接收流动池组件并且在垂直设置的垂直表面上提供电子接口。 块支撑流体界面并且可以在水平方向上移动，使得流体界面与流动池组件接触。
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公开(公告)号：US20190233887A1
公开(公告)日：2019-08-01
申请号：US16225720
申请日：2018-12-19
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jon A. HOSHIZAKI , Joon Mo YANG , Maryam SHARIATI , David M. COX , Kirk M. HIRANO , John BRIDGHAM , George Stefan GOLDA , Sam Lee WOO
IPC: C12Q1/6869 , G01N35/10 , B01F13/00 , B01F13/02 , B01J19/00 , C12Q1/6874 , B01L3/00 , G01N35/00
CPC classification number: C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
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公开(公告)号：US20150087530A1
公开(公告)日：2015-03-26
申请号：US14498979
申请日：2014-09-26
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jon A. HOSHIZAKI , Joon Mo YANG , Maryam SHARIATI , David M. COX , Kirk M. HIRANO , John BRIDGHAM , George Stefan GOLDA , Sam Lee WOO
IPC: C12Q1/68
CPC classification number: C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
Abstract: Various embodiments of a low-volume sequencing system are provided herein. The system can include a low-volume flowcell having at least one reaction chamber of a defined volume (e.g., less than about 100 μl). The system can also include an automated reagent delivery mechanism configured to reversibly couple with the inlet port corresponding to a target reaction chamber thereby placing allowing for reagent to be accurately moved from a storage container to the reaction chamber with minimal reagent waste. The flowcells can include a plurality of reaction chambers (e.g., 6) thereby allowing for parallel analysis of multiple samples. Various methods of analyzing a biomolecule are also provided herein.
Abstract translation: 本文提供了低体积测序系统的各种实施方案。 该系统可以包括具有至少一个具有确定体积（例如小于约100μl）的反应室的低体积流动池。 该系统还可以包括配置成与对应于目标反应室的入口端可逆耦合的自动化试剂输送机构，从而使试剂能够以最小的试剂废物从试剂容器准确地移动到反应室。 流通池可以包括多个反应室（例如6），从而允许多个样品的并行分析。 本文还提供了分析生物分子的各种方法。
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公开(公告)号：US20150083232A1
公开(公告)日：2015-03-26
申请号：US14558321
申请日：2014-12-02
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： David M. COX
CPC classification number: B01L9/50 , B01L3/502 , B01L3/502715 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/12 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , F16M13/02 , Y10S439/912 , Y10T137/0402 , Y10T137/598 , Y10T137/6966
Abstract: A vertical clamping device is provided that supports a flow cell component in a vertical configuration in which the flow cell is on an opposite side of the vertical support from the electronic interface. The clamp includes a vertical setting to receive the flow cell component and provides an electronic interface on a vertical surface of the vertical setting. A block supports the fluidics interface and can move in a horizontal direction bringing the fluidics interface into contact with the flow cell component.
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公开(公告)号：US20140061416A1
公开(公告)日：2014-03-06
申请号：US14015880
申请日：2013-08-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： David M. COX
IPC: F16M13/02
CPC classification number: B01L9/50 , B01L3/502 , B01L3/502715 , B01L9/52 , B01L9/527 , B01L2200/025 , B01L2200/026 , B01L2200/12 , B01L2300/0609 , B01L2300/0636 , B01L2300/0645 , B01L2300/0816 , F16M13/02 , Y10S439/912 , Y10T137/0402 , Y10T137/598 , Y10T137/6966
Abstract: A vertical clamping device is provided that supports a flow cell component in a vertical configuration in which the flow cell is on an opposite side of the vertical support from the electronic interface. The clamp includes a vertical setting to receive the flow cell component and provides an electronic interface on a vertical surface of the vertical setting. A block supports the fluidics interface and can move in a horizontal direction bringing the fluidics interface into contact with the flow cell component.
Abstract translation: 提供了一种垂直夹紧装置，其支撑垂直构造的流动池组件，其中流动池位于垂直支撑件与电子界面相反的一侧。 夹具包括垂直设置以接收流动池组件并且在垂直设置的垂直表面上提供电子接口。 块支撑流体界面并且可以在水平方向上移动，使得流体界面与流动池组件接触。
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