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20 条记录 (耗时 0.086 秒)

    Novel human membrane-associated protein and cell surface protein family members
    1.
    发明申请
    Novel human membrane-associated protein and cell surface protein family members 审中-公开
    新型人膜相关蛋白和细胞表面蛋白家族成员

    公开(公告)号：US20050019838A1

    公开(公告)日：2005-01-27

    申请号：US10860779

    申请日：2004-06-03

    申请人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Rosana Kapeller-Libermann ,  Rajasekhar Bandaru ,  Kevin Leiby

    发明人： Rachel Meyers ,  Maria Glucksmann ,  Rory Curtis ,  Rosana Kapeller-Libermann ,  Rajasekhar Bandaru ,  Kevin Leiby

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  G01N33/53 ,  C07H21/04 ,  G01N33/567

    CPC分类号： C07K14/47 ,  A01K2217/05 ,  A01K2217/075 ,  A61K38/00 ,  C07K14/705 ,  C07K14/70596 ,  C07K2319/00

    摘要： The invention provides isolated nucleic acids molecules, designated 16051a, 16051b, 58199, 57805, 56739, 39362, and 23228 nucleic acid molecules, which encode novel human membrane-associated protein family members, and human cell surface protein family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 gene has been introduced or disrupted. The invention still further provides isolated 16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 proteins, fusion proteins, antigenic peptides and anti-16051a, 16051b, 58199, 57805, 56739, 39362, or 23228 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供了编码新的人膜相关蛋白家族成员和人类细胞表面蛋白家族成员的分离的核酸分子，命名为16051a，16051b，58199,57805,56739,39362和23228核酸分子。 本发明还提供反义核酸分子，含有16051a，16051b，58199,57805,56739,39362或23228核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中16051a ，16051b，58199,57805,56739,39362或23228基因被引入或破坏。 本发明还进一步提供分离的16051a，16051b，58199,57805,56739,39362或23228蛋白，融合蛋白，抗原肽和抗-16051a，16051b，58199,57805,56739,39362或23228抗体。 还提供了利用本发明组合物的诊断方法。

    81588 methods and compositions of human proteins and uses thereof
    2.
    发明申请
    81588 methods and compositions of human proteins and uses thereof 审中-公开
    81588人蛋白质的方法和组合物及其用途

    公开(公告)号：US20060040306A1

    公开(公告)日：2006-02-23

    申请号：US11206587

    申请日：2005-08-18

    申请人： Kevin Leiby ,  Rosana Kapeller-Libermann ,  Maria Glucksmann

    发明人： Kevin Leiby ,  Rosana Kapeller-Libermann ,  Maria Glucksmann

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/06 ,  C07K14/82 ,  C07K16/30

    CPC分类号： C12N9/6489 ,  C07K14/705 ,  C07K2319/00 ,  C12N9/78 ,  C12Y304/24057 ,  C12Y305/04004

    摘要： The invention provides isolated nucleic acids molecules, designated 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, which encode novel adenosine deaminase, glycoprotease, or seven transmembrane receptor family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38650, 28472, 5495, 65507, 81588 or 14354 gene has been introduced or disrupted. The invention still further provides isolated 38650, 28472, 5495, 65507, 81588 or 14354 proteins, fusion proteins, antigenic peptides and anti-38650, 28472, 5495, 65507, 81588 or 14354 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供分离的核酸分子，命名为38650,28472,5495,65507,81588或14354核酸分子，其编码新的腺苷脱氨酶，糖蛋白酶或七个跨膜受体家族成员。 本发明还提供反义核酸分子，含有38650,28472,5495,65507,81588或14354核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中38650,28472， 5495,65507,81588或14354基因被引入或破坏。 本发明还进一步提供分离的38650,28472,5495,65507,81588或14354蛋白，融合蛋白，抗原肽和抗-38650,28472,5495,65507,81588或14354抗体。 还提供了利用本发明组合物的诊断方法。

    Novel human genes and methods of use thereof
    3.
    发明申请
    Novel human genes and methods of use thereof 审中-公开
    新型人类基因及其使用方法

    公开(公告)号：US20050214893A1

    公开(公告)日：2005-09-29

    申请号：US10968812

    申请日：2004-10-19

    申请人： Rachel Meyers ,  Rory Curtis ,  Maria Glucksmann ,  Rajasekhar Bandaru ,  Rosana Kapeller-Libermann

    发明人： Rachel Meyers ,  Rory Curtis ,  Maria Glucksmann ,  Rajasekhar Bandaru ,  Rosana Kapeller-Libermann

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/705 ,  C12N9/02 ,  C12N9/10 ,  C12N9/48 ,  C12N9/90 ,  C12Q1/26 ,  G01N33/574

    CPC分类号： C12N9/0004 ,  A61K38/00 ,  C07K14/47 ,  C07K14/4702 ,  C07K14/705 ,  C12N9/1048 ,  C12N9/48 ,  C12N9/90 ,  G01N33/57411 ,  G01N2500/04

    摘要： The invention provides isolated nucleic acids molecules, designated 47476, 67210, 49875,46842,33201, 83378,84233,64708, 85041,84234,21617, 55562,23566,33489, and 57779 nucleic acid molecules, which encode novel human genes. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 gene has been introduced or disrupted. The invention still further provides isolated 47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 proteins, fusion proteins, antigenic peptides and anti-47476, 67210, 49875, 46842, 33201, 83378, 84233, 64708, 85041, 84234, 21617, 55562, 23566, 33489, or 57779 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.

    摘要翻译： 本发明提供编码新的人基因的分离的核酸分子，命名为47476,67210,49875,46842,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489和57779核酸分子。 本发明还提供反义核酸分子，包含47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,161617,55562,23566,33489或57779核酸分子的重组表达载体，宿主细胞 已经引入了表达载体的非人类转基因动物，以及引入了47476,67210,49875,4642,43708,85041,84234,16617,55562,23566,33489或57779基因的非人类转基因动物，或 中断了 本发明还进一步提供分离的47476,67210,49875,4642,33201,83378,84233,64708,85041,84234,21617,55562,23566,33489或57779号蛋白，融合蛋白，抗原肽和抗-47476,67210， 49875,4462,33201,83378,84233,66708,85041,84234,21617,55562,253566,33489或57779抗体。 还提供了利用本发明组合物的诊断方法。

    14926 Receptor, a novel G-protein coupled receptor
    7.
    发明申请
    14926 Receptor, a novel G-protein coupled receptor 审中-公开
    14926受体，一种新型的G蛋白偶联受体

    公开(公告)号：US20060099687A1

    公开(公告)日：2006-05-11

    申请号：US11305477

    申请日：2005-12-16

    申请人： Maria Glucksmann ,  Immaculada Silos-Santiago

    发明人： Maria Glucksmann ,  Immaculada Silos-Santiago

    IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/705

    CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00

    摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

    摘要翻译： 本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。 本发明还涉及编码受体的多核苷酸。 本发明还涉及使用受体多肽和多核苷酸作为在受体介导的病症中进行诊断和治疗的靶标的方法。 本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生受体多肽和多核苷酸的方法。