公开(公告)号：US06978172B2

公开(公告)日：2005-12-20

申请号：US10335641

申请日：2002-12-30

Applicant: Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

Inventor： Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

IPC: A61N1/30 ,  A61N1/32

CPC classification number: A61N1/0424 ,  A61N1/042 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

Abstract: Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

Abstract translation: 将电穿孔电极层压到可渗透膜上以形成电极膜。 当与皮肤或粘膜直接接触并且以规定的间隔施加电场脉冲时，这种电极膜可用于连续控制递送治疗剂通过皮肤或粘膜。 可以组装电极膜，使得其在同一装置中并入离子电渗电极。 该装置可以共同用于通过皮肤和粘膜的电穿孔和离子电渗药物递送。

公开(公告)号：US06775569B2

公开(公告)日：2004-08-10

申请号：US08964872

申请日：1997-11-05

Applicant: Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

Inventor： Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

IPC: A61N130

CPC classification number: A61N1/0424 ,  A61N1/042 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

Abstract: Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

Abstract translation: 将电穿孔电极层压到可渗透膜上以形成电极膜。 当与皮肤或粘膜直接接触并且以规定的间隔施加电场脉冲时，这种电极膜可用于连续控制递送治疗剂通过皮肤或粘膜。 可以组装电极膜，使得其在同一装置中并入离子电渗电极。 该装置可以共同用于通过皮肤和粘膜的电穿孔和离子电渗药物递送。

公开(公告)号：US06490482B2

公开(公告)日：2002-12-03

申请号：US09186564

申请日：1998-11-04

Applicant: Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

Inventor： Kenji Mori ,  Iwao Nozawa ,  Shuji Sato

IPC: A61N130

CPC classification number: A61N1/0424 ,  A61N1/042 ,  A61N1/044 ,  A61N1/0444 ,  A61N1/327

Abstract: Electroporation electrodes are laminated to a permeable membrane to form an electrode membrane. Such an electrode membrane is useful for a continuous controlled delivery of a therapeutic agent through the skin or mucosa, when placed in direct contact with the skin or mucosa and by application of electric field pulses at specified intervals. An electrode membrane can be assembled such that it incorporates an iontophoretic electrode in the same device. This device can be jointly utilized for electroporation and iontophoretic drug delivery through the skin and mucosal membrane.

Abstract translation: 将电穿孔电极层压到可渗透膜上以形成电极膜。 当与皮肤或粘膜直接接触并且以规定的间隔施加电场脉冲时，这种电极膜可用于连续控制递送治疗剂通过皮肤或粘膜。 可以组装电极膜，使得其在同一装置中并入离子电渗电极。 该装置可以共同用于通过皮肤和粘膜的电穿孔和离子电渗药物递送。

公开(公告)号：US4968539A

公开(公告)日：1990-11-06

申请号：US277697

申请日：1988-11-30

Applicant: Takao Aoyagi ,  Shuji Sato ,  Minako Yasu ,  Iwao Nozawa ,  Yousuke Suzuki

Inventor： Takao Aoyagi ,  Shuji Sato ,  Minako Yasu ,  Iwao Nozawa ,  Yousuke Suzuki

IPC: A61K9/00 ,  A61K9/70 ,  B01D69/14 ,  C09K19/00 ,  C09K19/38

CPC classification number: A61K9/009 ,  A61K9/703 ,  A61K9/7084 ,  B01D69/141 ,  C09K19/00 ,  C09K19/38 ,  Y10S428/913 ,  Y10T428/1059

Abstract: A polymer membrane for delivering a drug is provided. The membrane is capable of regulating the delivery of the drug and comprises (A) a porous hydrophobic polymer membrane having a pore diameter of not larger than 3 .mu.m and a porosity of 10 to 90% which is immobilized with (B) a specific liquid crystal-forming compound having a gel/liquid crystal transition temperature in the range of 25.degree. to 45.degree. C.

Abstract translation: 提供了用于递送药物的聚合物膜。 该膜能够调节药物的输送，并且包含（A）孔径不大于3μm的孔隙率为10〜90％的多孔疏水性聚合物膜，其固定有（B）特定液体 凝胶/液晶转变温度在25〜45℃范围内的结晶化合物

公开(公告)号：US5573779A

公开(公告)日：1996-11-12

申请号：US313231

申请日：1994-09-30

Applicant: Shuji Sato ,  Iwao Nozawa ,  Katsuhiko Akiyama

Inventor： Shuji Sato ,  Iwao Nozawa ,  Katsuhiko Akiyama

IPC: A61K9/127 ,  A61K47/48

CPC classification number: A61K9/127 ,  Y10S436/829

Abstract: A liposome composition which is effective in administering a physiologically active substance to Peyer's patches and is characterized by containing phosphatidylcholine, cholesterol and phosphatidylinositol as lipid components and having a high ability to migrate into Peyer's patches.

Abstract translation: PCT No.PCT / JP93 / 00460 Sec。 371日期1994年9月30日 102（e）1994年9月30日PCT 1993年4月9日PCT PCT。 公开号WO93 / 20801 日期：1993年10月28日一种脂质体组合物，其有效地将生理活性物质施用于派耶尔斑块，其特征在于含有磷脂酰胆碱，胆固醇和磷脂酰肌醇作为脂质成分并且具有高迁移到派尔氏贴剂的能力。

公开(公告)号：US20050085860A1

公开(公告)日：2005-04-21

申请号：US10501946

申请日：2003-01-20

Applicant: Kenji Mori ,  Seiji Tokumoto ,  Naruhito Higo ,  Shuji Sato ,  Kenji Sugibayashi

Inventor： Kenji Mori ,  Seiji Tokumoto ,  Naruhito Higo ,  Shuji Sato ,  Kenji Sugibayashi

IPC: A61K9/70 ,  A61K31/05 ,  A61K31/155 ,  A61K31/192 ,  A61K31/196 ,  A61K31/375 ,  A61K47/36 ,  A61N1/30 ,  A61P25/04 ,  A61P39/06 ,  A61P43/00

CPC classification number: A61N1/30

Abstract: A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).

Abstract translation: 提供了用于电穿孔的经皮或经粘膜给药的制剂，其能够有效施用待给药的化合物例如药物。 透皮或经粘膜给药用于电穿孔的制剂包括其中分散有固体或半固体形式的基质中的待给药化合物（生理活性物质）如药物的药物储存器（11），背衬（12） 保持药物储存器和设置在药物储存器（11）上的一对用于电穿孔的电极（13）。 粘合剂层（14）设置在背衬（12）的凸缘部分上。 绝缘层（15）设置在用于电穿孔（13）的电极的至少一部分上，接触除了药物储存器（11）上的部分之外的施用部位。

公开(公告)号：US07502654B2

公开(公告)日：2009-03-10

申请号：US10517535

申请日：2003-06-11

Applicant: Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

Inventor： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

IPC: A61N1/00

CPC classification number: A61N1/0492 ,  A61B2562/187 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0448

Abstract: The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).

Abstract translation: 本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。 电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。 突出部70配置成包围凹部60的外周。 当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。 因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

公开(公告)号：US20060206186A1

公开(公告)日：2006-09-14

申请号：US10517535

申请日：2003-06-11

Applicant: Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

Inventor： Kenji Mori ,  Hiroyuki Maeda ,  Naruhito Higo ,  Shuji Sato ,  Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi

IPC: A61N1/04

CPC classification number: A61N1/0492 ,  A61B2562/187 ,  A61N1/0424 ,  A61N1/044 ,  A61N1/0448

Abstract: The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed. An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).

Abstract translation: 本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。 电极装置（10）具有突出部（70），该突起部（70）在除了通过模制形成的凹部（60）之外的向外的凸缘部分（110f）的一部分中向上突出。 突出部70配置成包围凹部60的外周。 当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中的翘曲（沿着周向的翘曲）发生。 因此，突起（70）还可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，并防止电极层（30）断开。

公开(公告)号：US20050113738A1

公开(公告)日：2005-05-26

申请号：US10500537

申请日：2003-01-09

Applicant: Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi ,  Takuji Oikawa ,  Shuji Sato ,  Naruhito Higo ,  Hiroyuki Maeda ,  Kenji Mori

Inventor： Yasushi Fuchita ,  Tatsuya Ogawa ,  Saori Takahashi ,  Takuji Oikawa ,  Shuji Sato ,  Naruhito Higo ,  Hiroyuki Maeda ,  Kenji Mori

IPC: A61N1/30

CPC classification number: A61N1/0436 ,  A61N1/044

Abstract: There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.

Abstract translation: 提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。 为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。 片材（50）具有使凝胶（70）渗透到其中的性质。 由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

公开(公告)号：US20100324469A1

公开(公告)日：2010-12-23

申请号：US12681508

申请日：2008-10-03

Applicant: Kenji Mori ,  Takamitsu Miyagi ,  Yayoi Shimada ,  Kuei-Chen Chiang ,  Naoya Ohmori ,  Takeshi Goto ,  Shuji Sato

Inventor： Kenji Mori ,  Takamitsu Miyagi ,  Yayoi Shimada ,  Kuei-Chen Chiang ,  Naoya Ohmori ,  Takeshi Goto ,  Shuji Sato

IPC: A61N1/30

CPC classification number: A61N1/0448 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61N1/0436 ,  A61N1/0444 ,  A61N1/30 ,  A61N1/325

Abstract: It is an object of the present invention to provide a method and an apparatus capable of noninvasively administrating vaccine through the skin, and thereby making the immune response activate. A drug product according to the present invention is characterized in that the drug product has a support medium, an electrode formed on the support medium and protected partly by an insulating material for avoiding a direct cutaneous contact, a vaccine containing layer for containing a vaccine, wherein the vaccine is an antigen for inducing an immune suppression protein. A method of administrating a vaccine according to the present invention is characterized in that the vaccine is administrated by the iontophoresis using the drug product according to the drug product of the present invention as an electrode. An apparatus for the iontophoresis according to the present invention is characterized in that the drug product according to the present invention is used as an electrode.

Abstract translation: 本发明的目的是提供一种能够通过皮肤无刺激地施用疫苗，从而使免疫反应活化的方法和装置。 根据本发明的药物产品的特征在于药物产品具有载体介质，形成在载体介质上的电极，部分地被绝缘材料保护以避免直接皮肤接触，含有疫苗的疫苗含有层， 其中所述疫苗是用于诱导免疫抑制蛋白的抗原。 本发明疫苗的施用方法的特征在于，使用本发明药物的药物作为电极，通过离子电渗法给予疫苗。 本发明的离子电渗疗法的特征在于，将本发明的药物用作电极。