公开(公告)号：US08185367B2

公开(公告)日：2012-05-22

申请号：US11587900

申请日：2005-05-02

申请人： Jun Zhu ,  Eric E. Schadt

发明人： Jun Zhu ,  Eric E. Schadt

IPC分类号： G06G7/58

CPC分类号： G06F19/12 ,  G06F19/24

摘要： The reconstruction of genetic networks in mammalian systems is one of the primary goals in biological research, especially as such reconstructions relate to elucidating not only common, polygenic human disease, but living systems more generally. The present invention provides novel gene network reconstruction algorithms that utilize naturally occurring genetic variations as a source of perturbations to elucidate the networks. The algorithms incorporate relative transcript abundance and genotypic data from segregating populations by employing a generalized scoring function of maximum likelihood commonly used in Bayesian network reconstruction problems. The utility of these novel algorithms can be demonstrated via application to gene expression data from a segregating mouse population. The network derived from such data using the novel network reconstruction algorithm is able to capture causal associations between genes that result in increased predictive power, compared to more classically reconstructed networks derived from the same data.

摘要翻译： 哺乳动物系统中遗传网络的重建是生物研究的主要目标之一，特别是因为这些重建不仅涉及常见的多基因人类疾病，而且更广泛地阐明生物系统。 本发明提供了利用天然存在的遗传变异作为扰动源来阐明网络的新型基因网络重建算法。 该算法通过采用在贝叶斯网络重建问题中常用的最大似然度的广义评分函数，将相对转录丰度和来自分离群体的基因型数据结合起来。 这些新算法的实用性可以通过应用于分离的小鼠群体的基因表达数据来证明。 与使用相同数据导出的更经典的重建网络相比，使用新颖的网络重构算法从这种数据得到的网络能够捕获导致增加的预测能力的基因之间的因果关联。

公开(公告)号：US20080294403A1

公开(公告)日：2008-11-27

申请号：US11587900

申请日：2005-05-02

申请人： Jun Zhu ,  Eric E. Schadt

发明人： Jun Zhu ,  Eric E. Schadt

IPC分类号： G06G7/58

CPC分类号： G06F19/12 ,  G06F19/24

摘要： The reconstruction of genetic networks in mammalian systems is one of the primary goals in biological research, especially as such reconstructions relate to elucidating not only common, polygenic human disease, but living systems more generally. The present invention provides novel gene network reconstruction algorithms that utilize naturally occurring genetic variations as a source of perturbations to elucidate the networks. The algorithms incorporate relative transcript abundance and genotypic data from segregating populations by employing a generalized scoring function of maximum likelihood commonly used in Bayesian network reconstruction problems. The utility of these novel algorithms can be demonstrated via application to gene expression data from a segregating mouse population. The network derived from such data using the novel network reconstruction algorithm is able to capture causal associations between genes that result in increased predictive power, compared to more classically reconstructed networks derived from the same data.

摘要翻译： 哺乳动物系统中遗传网络的重建是生物研究的主要目标之一，特别是因为这些重建不仅涉及常见的多基因人类疾病，而且更广泛地阐明生物系统。 本发明提供了利用天然存在的遗传变异作为扰动源来阐明网络的新型基因网络重建算法。 该算法通过采用在贝叶斯网络重建问题中常用的最大似然度的广义评分函数，将相对转录丰度和来自分离群体的基因型数据结合起来。 这些新算法的实用性可以通过应用于分离的小鼠群体的基因表达数据来证明。 与使用相同数据导出的更经典的重建网络相比，使用新颖的网络重构算法从这种数据得到的网络能够捕获导致增加的预测能力的基因之间的因果关联。

公开(公告)号：US20180255829A1

公开(公告)日：2018-09-13

申请号：US15457209

申请日：2017-03-13

申请人： Jun Zhu

发明人： Jun Zhu

IPC分类号： A24D1/04 ,  A24D3/10 ,  A24D3/16 ,  A24D3/14 ,  A24D3/02

CPC分类号： A24D1/045 ,  A24D3/0245 ,  A24D3/10 ,  A24D3/14 ,  A24D3/163

摘要： The invention discloses a filter-tipped cigarette comprising a filter tip. The filter tip comprises a plurality of filter elements twisted together by mutually winding. All the filter elements are cellulose acetate fiber bundles. In the invention, since the filter elements are disposed in the way of winding, a total length of the filter elements is increased, a travel of a smoke passing through the filter elements is thereby increased, and thus harmful ingredients in the cigarette are filtered more thoroughly.

公开(公告)号：US09009652B2

公开(公告)日：2015-04-14

申请号：US12913913

申请日：2010-10-28

申请人： Ying Huang ,  Ying Liu ,  Wei Zhao ,  Xin Zhou ,  Jun Zhu

发明人： Ying Huang ,  Ying Liu ,  Wei Zhao ,  Xin Zhou ,  Jun Zhu

IPC分类号： G06F9/44

CPC分类号： G06F8/71

摘要： A method and a system for identifying and resolving conflicts between design results from a parallel software design. The method includes: receiving a design diagram, wherein the design diagram includes a plurality of nodes and arrows connecting different nodes, with each node indicating a design artifact, and an arrow directed from one node to another node indicating that a design artifact corresponds to the one node depends on a design artifact corresponding to the other node; determining a level of a design artifact in the design diagram, identifying different design artifacts at a given level of the design diagram that depend on a common design artifact, and marking them as isomorphic design artifacts; and outputting a design diagram with the isomorphic design artifacts marked. A conflict between relevant designs are automatically identified in a bottom-up approach according to a software design hierarchy to facilitate conflict resolution.

摘要翻译： 一种用于识别和解决来自并行软件设计的设计结果之间冲突的方法和系统。 该方法包括：接收设计图，其中设计图包括连接不同节点的多个节点和箭头，每个节点指示设计工件，以及从一个节点指向另一个节点的箭头，指示设计工件对应于 一个节点取决于对应于另一个节点的设计工件; 确定设计图中的设计工件的水平，识别依赖于常见设计工件的设计图的给定级别的不同设计工件，并将其标记为同构设计工件; 并输出具有标记的同构设计工件的设计图。 根据软件设计层次结构，自下而上的方法会自动识别相关设计之间的冲突，以促进冲突解决。

公开(公告)号：US20140301120A1

公开(公告)日：2014-10-09

申请号：US14354285

申请日：2011-10-28

申请人： Huibin Zhu ,  David Smith ,  Jun Zhu ,  Xueqin Wu

发明人： Huibin Zhu ,  David Smith ,  Jun Zhu ,  Xueqin Wu

IPC分类号： H02M1/36 ,  H02H7/12 ,  H02J3/38

CPC分类号： H02M1/36 ,  H02H3/066 ,  H02H7/06 ,  H02H7/12 ,  H02J3/38 ,  H02J3/383 ,  H02J3/40 ,  Y02E10/563

摘要： Systems, power modules (108), and methods (200) for using in controlling a converter (110) coupled between a power generator (104) and an electric grid (102) are provided. One of the power modules (108) includes the converter (110) configured to supply an output from the power generator (104) to the electric grid (102), and a controller (112) coupled to the converter (110). The controller (112) includes a phase-lock-loop (PLL) module (123) and at least one regulator (128, 130). The at least one regulator (128, 130) is configured to at least partially control the converter (110) as a function of at least one parameter. The controller (112) is configured to disable the converter (110) in response to a grid fault event, to maintain coupling between the power generator (104) and the converter (110) during the grid fault event, to determine whether the PLL module (123) is locked onto a voltage associated with the electric grid, to adjust the at least one parameter after the grid fault event, and to re-enable the converter to supply the output from the power generator (104) to the electric grid (102).

摘要翻译： 提供了用于控制耦合在发电机（104）和电网（102）之间的转换器（110）的系统，功率模块（108）和方法（200）。 功率模块（108）中的一个包括被配置为将功率发生器（104）的输出提供给电网（102）的转换器（110）和耦合到转换器（110）的控制器（112）。 控制器（112）包括锁相环（PLL）模块（123）和至少一个调节器（128,130）。 至少一个调节器（128,130）被配置为至少部分地根据至少一个参数来控制转换器（110）。 控制器（112）被配置为响应于电网故障事件禁用转换器（110），以在电网故障事件期间保持发电机（104）和转换器（110）之间的耦合，以确定PLL模块 （123）被锁定在与所述电网相关联的电压上，以在所述电网故障事件之后调整所述至少一个参数，并且重新使得所述转换器将所述发电机（104）的输出提供给所述电网（ 102）。

公开(公告)号：US08727939B2

公开(公告)日：2014-05-20

申请号：US13513843

申请日：2010-11-30

申请人： Hong Chen ,  Zhixin Chen ,  Weimin Gao ,  Jun Zhu ,  Sidong Luo ,  Hailong Ge ,  Jian Wang ,  Yanglong Chen

发明人： Hong Chen ,  Zhixin Chen ,  Weimin Gao ,  Jun Zhu ,  Sidong Luo ,  Hailong Ge ,  Jian Wang ,  Yanglong Chen

IPC分类号： F16H3/091

CPC分类号： B60K6/442 ,  B60K6/387 ,  B60K6/54 ,  B60K6/547 ,  B60K2006/541 ,  B60L11/123 ,  B60L11/14 ,  B60L15/2054 ,  B60W10/02 ,  B60W10/06 ,  B60W10/08 ,  B60W10/11 ,  B60W30/19 ,  Y02T10/6217 ,  Y02T10/6234 ,  Y02T10/6269 ,  Y02T10/6286 ,  Y02T10/645 ,  Y02T10/7077 ,  Y02T10/72 ,  Y02T10/7275 ,  Y10T74/19223 ,  Y10T477/23 ,  Y10T477/24 ,  Y10T477/26

摘要： A series/parallel hybrid electric drive unit for vehicle comprises an engine (1), a main traction motor (2), an integrated starter-generator (3), a differential (4), a first shaft (main shaft) (5), a first stage decelerating device (9), a second stage decelerating device (10), a first clutch (6), a second clutch (7) and a synchronizer (8). The synchronizer (8) is slidably arranged on the first shaft (5) which is connected to the first stage decelerating device (9) or the second stage decelerating device (10) by the synchronizer (8), respectively. The hybrid electric drive unit of the invention has a compactly-arranged internal structure and an efficient and appropriate internal connection, and a switch between connection and disconnection of respective hybrid power sources and wheels and a shifting among operating modes and gear positions of the hybrid drive system can be realized.

摘要翻译： 用于车辆的串联/并联混合电动驱动单元包括发动机（1），主牵引电动机（2），集成起动发电机（3），差速器（4），第一轴（主轴） ，第一级减速装置（9），第二级减速装置（10），第一离合器（6），第二离合器（7）和同步器（8）。 同步器（8）可滑动地布置在第一轴（5）上，第一轴（5）分别通过同步器（8）连接到第一级减速装置（9）或第二级减速装置（10）。 本发明的混合动力驱动单元具有紧凑布置的内部结构和有效且适当的内部连接，以及在混合动力源和车轮的连接和断开之间的切换以及混合动力驱动器的操作模式和档位之间的换档 系统可以实现。

公开(公告)号：US08665429B2

公开(公告)日：2014-03-04

申请号：US13729522

申请日：2012-12-28

申请人： Kai-Li Jiang ,  Jun Zhu ,  Chen Feng ,  Shou-Shan Fan

发明人： Kai-Li Jiang ,  Jun Zhu ,  Chen Feng ,  Shou-Shan Fan

IPC分类号： G01J1/00 ,  G01J1/42

CPC分类号： G01J1/4257 ,  B82Y30/00 ,  B82Y40/00 ,  G01J1/4228 ,  G01J5/023 ,  G01J5/0853 ,  G01J5/524 ,  G01J2005/0077 ,  H01J37/26

摘要： A method for measuring intensity distribution of light includes a step of providing a carbon nanotube array having a top surface. The carbon nanotube array is located in an inert gas environment or a vacuum environment. A light source irradiates the top surface of the carbon nanotube array, to make the carbon nanotube array radiate a radiation light. An imaging element images the radiation light, to obtain an intensity distribution of the light source.

摘要翻译： 用于测量光的强度分布的方法包括提供具有顶表面的碳纳米管阵列的步骤。 碳纳米管阵列位于惰性气体环境或真空环境中。 光源照射碳纳米管阵列的顶表面，使得碳纳米管阵列辐射出辐射光。 成像元件对辐射光进行成像，以获得光源的强度分布。

公开(公告)号：US20130309212A1

公开(公告)日：2013-11-21

申请号：US13982965

申请日：2012-01-17

申请人： Ming Zhang ,  Fang Wang ,  Huiyuan Guo ,  Jun Zhu ,  Lu Jiang

发明人： Ming Zhang ,  Fang Wang ,  Huiyuan Guo ,  Jun Zhu ,  Lu Jiang

IPC分类号： A61K35/74

CPC分类号： A61K35/74 ,  A23L33/135 ,  A23Y2220/79 ,  A61K35/747 ,  C12N1/20 ,  C12R1/225

摘要： Provided is a Lactobacillus salivarius belonging to Lactobacillus salivarius subsp. Salivarius and deposited in China General Microbiological Culture Collection Center with an accession number CGMCC No: 3606. Further provided is a method for preparing a metabolite of the Lactobacillus salivarius, wherein the Lactobacillus salivarius is as described above. Further provided is a composition, comprising viable strains of the Lactobacillus salivarius and/or the metabolite of the Lactobacillus salivarius prepared as described above. Further provided is a use of the composition in preparation of drugs for prevention and/or treatment of cancers and a method for treating and/or preventing cancers. The viable strains of Lactobacillus salivarius and the metabolite of Lactobacillus salivarius provided in the present invention can both remove the genotoxicity of 4-NQQ in vivo, thus exerting an effect of effectively preventing and/or treating cancers.

摘要翻译： 本发明提供一种属于唾液乳杆菌的唾液乳杆菌属（Lactobacillus salivarius）。 唾液疣并存入中国通用微生物培养物收集中心，登录号CGMCC No：3606.进一步提供了一种制备唾液乳杆菌代谢物的方法，其中唾液乳杆菌如上所述。 进一步提供了一种组合物，其包含如上所述制备的唾液乳杆菌和/或唾液乳杆菌的代谢物的活菌株。 还提供了该组合物在制备用于预防和/或治疗癌症的药物中的用途以及用于治疗和/或预防癌症的方法。 本发明提供的唾液乳杆菌和唾液乳杆菌的代谢物的活菌可以在体内消除4-NQQ的基因毒性，从而发挥有效预防和/或治疗癌症的作用。

公开(公告)号：US08574876B2

公开(公告)日：2013-11-05

申请号：US13436506

申请日：2012-03-30

申请人： Benjamin Mijts ,  Sheela Muley ,  Jack Liang ,  Lisa M. Newman ,  Xiyun Zhang ,  James Lalonde ,  Michael D. Clay ,  Jun Zhu ,  John M. Gruber ,  Jeffrey Colbeck ,  John D. Munger, Jr. ,  Jagadeesh Mavinahalli ,  Roger Sheldon

发明人： Benjamin Mijts ,  Sheela Muley ,  Jack Liang ,  Lisa M. Newman ,  Xiyun Zhang ,  James Lalonde ,  Michael D. Clay ,  Jun Zhu ,  John M. Gruber ,  Jeffrey Colbeck ,  John D. Munger, Jr. ,  Jagadeesh Mavinahalli ,  Roger Sheldon

IPC分类号： C12P7/62 ,  C12P13/22

CPC分类号： C07D403/04 ,  C07D209/02 ,  C07D403/12 ,  C07D487/04 ,  C12P13/24 ,  C12P17/10 ,  C12P17/188 ,  C12Y104/03004

摘要： The present disclosure provides substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, wherein A, M, M′, and R5 are as described herein, and to biocatalytic processes for their preparation, and to the enzymes used in those processes.

摘要翻译： 本公开提供了基本上对映体纯的以下结构式的杂双环化合物，其中A，M，M'和R 5如本文所述，以及其制备的生物催化方法，以及用于这些方法的酶。

公开(公告)号：US08495583B2

公开(公告)日：2013-07-23

申请号：US12558147

申请日：2009-09-11

申请人： Kathryn A. Bassin ,  Howard M. Hess ,  Sheng Huang ,  Steven Kagan ,  Shao C. Li ,  Zhong J. Li ,  He H. Liu ,  Susan E. Skrabanek ,  Hua F. Tan ,  Jun Zhu

发明人： Kathryn A. Bassin ,  Howard M. Hess ,  Sheng Huang ,  Steven Kagan ,  Shao C. Li ,  Zhong J. Li ,  He H. Liu ,  Susan E. Skrabanek ,  Hua F. Tan ,  Jun Zhu

IPC分类号： G06F9/44 ,  G06F11/34

CPC分类号： G06Q10/0635 ,  G06F8/10 ,  G06F11/008 ,  G06F11/3466

摘要： A method is implemented in a computer infrastructure having computer executable code tangibly embodied on a computer readable storage medium having programming instructions. The programming instructions are operable to receive one or more risk factors, receive one or more contexts, identify one or more context relationships and associate the one or more contexts with the one or more risk factors. Additionally, the programming instructions are operable to map the one or more risk factors for an associated context to a software defect related risk consequence to determine a risk model and execute a risk-based testing based on the risk model to determine a defect related risk evaluation for a software development project.

摘要翻译： 在具有计算机可执行代码的计算机基础设施中实现一种方法，其有形地体现在具有编程指令的计算机可读存储介质上。 所述编程指令可操作以接收一个或多个风险因素，接收一个或多个上下文，识别一个或多个上下文关系并将所述一个或多个上下文与所述一个或多个风险因子相关联。 此外，编程指令可操作以将相关联的上下文的一个或多个风险因素映射到与软件缺陷相关的风险结果，以确定风险模型并基于风险模型执行基于风险的测试，以确定缺陷相关风险评估 用于软件开发项目。