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    Compositions comprising MG29 nucleic acids, polypeptides, and associated methods of use
    2.
    发明授权
    Compositions comprising MG29 nucleic acids, polypeptides, and associated methods of use 有权
    包含MG29核酸，多肽和相关使用方法的组合物

    公开(公告)号：US08603992B2

    公开(公告)日：2013-12-10

    申请号：US12504331

    申请日：2009-07-16

    申请人： Jianjie Ma ,  Noah Weisleder

    发明人： Jianjie Ma ,  Noah Weisleder

    IPC分类号： C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： A61K35/34 ,  A01K67/0275 ,  A01K2217/058 ,  A01K2217/203 ,  A01K2217/206 ,  A01K2227/105 ,  A01K2267/03 ,  A61K38/00 ,  A61K38/1709 ,  C07K14/705 ,  C12N15/8509 ,  C12N2800/30 ,  C12N2840/20 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： Disclosed herein are compositions and methods for treatment of muscle dysfunction (including sarcopenia) and other diseases involving skeletal muscle, including age-related muscle dysfunction. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the treatment of skeletal muscle disorder, including those related to thr normal aging process. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with altered intracellular Ca2+ regulation and disrupted membrane structure that occurs when the expression levels of MG29 are reduced.

    摘要翻译： 本文公开了用于治疗肌肉功能障碍（包括肌营养不良）和涉及骨骼肌的其它疾病（包括年龄相关的肌肉功能障碍）的组合物和方法。 此外，本发明涉及包含与药学上可接受的载体组合的本发明的核苷酸和/或多肽的治疗组合物，其中所述组合物有助于骨骼肌疾病的治疗，包括与正常老化过程相关的那些。 此外，本发明涉及治疗和/或预防与MG29的表达水平降低时发生的改变的细胞内Ca 2+调节和破坏的膜结构相关的病理状况。

    ATAP peptides, nucleic acids encoding the same and associated methods of use
    3.
    发明授权
    ATAP peptides, nucleic acids encoding the same and associated methods of use 有权
    ATAP肽，编码相同和相关使用方法的核酸

    公开(公告)号：US09505821B2

    公开(公告)日：2016-11-29

    申请号：US12444288

    申请日：2007-10-03

    申请人： Jianjie Ma ,  Jae-Kyun Ko ,  Chul-Woo Kim ,  Noah Weisleder

    发明人： Jianjie Ma ,  Jae-Kyun Ko ,  Chul-Woo Kim ,  Noah Weisleder

    IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47

    CPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/4747 ,  C07K2319/10 ,  C07K2319/21 ,  C07K2319/60

    摘要： Disclosed herein are nucleic acid sequences that encode pro-apoptotic polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of proliferative disorders and bacterial infections using the nucleic acids and proteins of the invention.

    摘要翻译： 本文公开了编码促凋亡多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了使用本发明的核酸和蛋白质进行诊断，治疗和预防增殖性疾病和细菌感染的治疗，诊断和研究方法。

    Serum MG53 as a diagnostic marker for tissue injury
    4.
    发明授权
    Serum MG53 as a diagnostic marker for tissue injury 有权
    血清MG53作为组织损伤的诊断标志物

    公开(公告)号：US08420338B2

    公开(公告)日：2013-04-16

    申请号：US13290070

    申请日：2011-11-05

    申请人： Noah Weisleder ,  Jianjie Ma

    发明人： Noah Weisleder ,  Jianjie Ma

    IPC分类号： G01N33/53 ,  G01N31/00

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N33/6887

    摘要： Disclosed herein are compositions and methods for measuring the level of MG53 found in a biological fluid as a biomarker for a disease or disorder, e.g., tissue damage, exercise capacity or a muscle-related disease or disorder. In addition, the invention relates to targeting the native MG53 found in the blood as a therapeutic approach.

    摘要翻译： 本文公开了用于测量在生物流体中发现的MG53的水平作为疾病或病症的生物标志物例如组织损伤，运动能力或与肌肉相关的疾病或病症的水平的组合物和方法。 此外，本发明涉及靶向血液中存在的天然MG53作为治疗方法。

    MG53 compositions and methods of use
    6.
    发明授权
    MG53 compositions and methods of use 有权
    MG53组合物和使用方法

    公开(公告)号：US07981866B2

    公开(公告)日：2011-07-19

    申请号：US12307303

    申请日：2007-07-11

    申请人： Jianjie Ma ,  Noah Weisleder ,  Chuanxi Cai

    发明人： Jianjie Ma ,  Noah Weisleder ,  Chuanxi Cai

    IPC分类号： A61K38/17 ,  A61K38/39

    CPC分类号： C07K14/4702 ,  A01K67/0276 ,  A01K2217/075 ,  A01K2227/105 ,  A01K2267/0375 ,  C07K16/18 ,  C07K2319/10 ,  C12N15/8509 ,  C40B30/06 ,  C40B40/02

    摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

    摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。