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公开(公告)号：US20110287015A1
公开(公告)日：2011-11-24
申请号：US13152077
申请日：2011-06-02
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
IPC分类号： A61K39/395 , C12N5/071 , G01N33/566 , A61P43/00 , C12N1/21 , C12N5/10 , C12N1/19 , C07K16/18 , C07H21/00
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K16/18 , C07K2319/10 , C12N15/8509 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
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公开(公告)号：US07981866B2
公开(公告)日：2011-07-19
申请号：US12307303
申请日：2007-07-11
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K16/18 , C07K2319/10 , C12N15/8509 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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3.发明授权Compositions and methods for preparing recombinant MG53 and methods for optimizing same 有权制备重组MG53的组合物和方法及其优化方法公开(公告)号：US09139630B2
公开(公告)日：2015-09-22
申请号：US13526954
申请日：2012-06-19
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
IPC分类号： C12P21/02 , C12N15/09 , C12N15/12 , C12N15/63 , C12N5/10 , C07H21/04 , C07K14/435 , C07K14/475 , C07K14/47 , A01K67/027 , C07K16/18 , C12N15/85 , C40B30/06 , C40B40/02 , C12N15/86 , C12N5/00
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07H21/04 , C07K14/435 , C07K14/475 , C07K16/18 , C07K2319/10 , C07K2319/21 , C07K2319/24 , C07K2319/35 , C12N5/00 , C12N15/09 , C12N15/63 , C12N15/85 , C12N15/8509 , C12N15/86 , C12N2310/351 , C12N2800/22 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. In particular, the present invention provides nucleic acid molecules that include optimization features that enhance the expression and/or recovery and/or activity of encoded polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 特别地，本发明提供核酸分子，其包括增强编码多肽的表达和/或恢复和/或活性的优化特征。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20090208473A1
公开(公告)日：2009-08-20
申请号：US12328646
申请日：2008-12-04
申请人： Noah Weisleder , Chuanxi Cai , Jianjie Ma
发明人： Noah Weisleder , Chuanxi Cai , Jianjie Ma
CPC分类号： C12N15/62 , A61K38/53 , C07K14/4716 , C12N9/93
摘要： Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the repair of cell membranes. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with cell membrane damage.
摘要翻译： 本文公开了用于修复细胞膜的组合物和方法。 此外，本发明涉及包含与药学上可接受的载体组合的本发明的核苷酸和/或多肽的治疗组合物，其中所述组合物促进细胞膜的修复。 此外，本发明涉及治疗和/或预防与细胞膜损伤相关的病理状况。
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公开(公告)号：US09458465B2
公开(公告)日：2016-10-04
申请号：US12328646
申请日：2008-12-04
申请人： Noah Weisleder , Chuanxi Cai , Jianjie Ma
发明人： Noah Weisleder , Chuanxi Cai , Jianjie Ma
CPC分类号： C12N15/62 , A61K38/53 , C07K14/4716 , C12N9/93
摘要： Disclosed herein are compositions and methods for repairing cell membranes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or polypeptides of the invention in combination with a pharmaceutically acceptable carrier, wherein the composition facilitates the repair of cell membranes. Moreover, the invention relates to the treatment and/or prevention of pathological conditions associated with cell membrane damage.
摘要翻译： 本文公开了用于修复细胞膜的组合物和方法。 此外，本发明涉及包含与药学上可接受的载体组合的本发明的核苷酸和/或多肽的治疗组合物，其中所述组合物促进细胞膜的修复。 此外，本发明涉及治疗和/或预防与细胞膜损伤相关的病理状况。
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6.发明申请COMPOSITIONS AND METHODS FOR PREPARING RECOMBINANT MG53 AND METHODS FOR OPTIMIZING SAME 有权制备重组MG53的组合物和方法及其优化方法公开(公告)号：US20120309051A1
公开(公告)日：2012-12-06
申请号：US13526954
申请日：2012-06-19
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07H21/04 , C07K14/435 , C07K14/475 , C07K16/18 , C07K2319/10 , C07K2319/21 , C07K2319/24 , C07K2319/35 , C12N5/00 , C12N15/09 , C12N15/63 , C12N15/85 , C12N15/8509 , C12N15/86 , C12N2310/351 , C12N2800/22 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. In particular, the present invention provides nucleic acid molecules that include optimization features that enhance the expression and/or recovery and/or activity of encoded polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 特别地，本发明提供核酸分子，其包括增强编码多肽的表达和/或恢复和/或活性的优化特征。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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公开(公告)号：US20110287004A1
公开(公告)日：2011-11-24
申请号：US13152096
申请日：2011-06-02
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
IPC分类号： A61K39/395 , A61K38/14 , A61K38/45 , A61K48/00 , A61P43/00 , C12N5/10 , C12N1/19 , C07H21/04 , C07H21/02 , A61P21/00 , A61K31/7088 , C12N1/21
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K16/18 , C07K2319/10 , C12N15/8509 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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8.发明申请公开(公告)号：US20090318348A1
公开(公告)日：2009-12-24
申请号：US12307303
申请日：2007-07-11
申请人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
发明人： Jianjie Ma , Noah Weisleder , Chuanxi Cai
IPC分类号： A61K38/17 , C12N15/12 , C12N15/79 , C12N5/10 , C12N1/00 , A61K31/711 , C07K14/435 , C40B30/06 , C12Q1/68 , C07K16/18 , C12N15/74
CPC分类号： C07K14/4702 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0375 , C07K16/18 , C07K2319/10 , C12N15/8509 , C40B30/06 , C40B40/02
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforementioned polypeptide, polynucleotide, or antibody. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译： 本文公开了编码新型多肽的核酸序列。 还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体以及上述多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。 本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。
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