公开(公告)号：US11603405B2

公开(公告)日：2023-03-14

申请号：US16418082

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Francois Gaudet ,  Jill Giles-Komar ,  Bradley Heidrich ,  Chichi Huang ,  Colleen Kane ,  Ronan McDaid ,  Jennifer Nemeth-Seay

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The present invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.

公开(公告)号：US20220054634A1

公开(公告)日：2022-02-24

申请号：US17522423

申请日：2021-11-09

Applicant: Janssen Biotech, Inc.

Inventor： Jacquelne Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill Giles-Komar ,  Jinquan Luo ,  Michael Rycyzyn ,  Raymond Sweet

IPC: A61K39/395 ,  G01N33/68 ,  C07K16/24 ,  A61K45/06

Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20170290912A1

公开(公告)日：2017-10-12

申请号：US15626697

申请日：2017-06-19

Applicant: Janssen Biotech, Inc.

Inventor： Jacqueline Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill Giles-Komar ,  Jinquan Luo ,  Michael Rycyzyn ,  Raymond Sweet

IPC: A61K39/395 ,  A61K45/06

CPC classification number: A61K39/3955 ,  A61K39/00 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/55527 ,  A61K2039/55544 ,  C07K16/244 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/55 ,  G01N33/6869 ,  G01N2333/54 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/57 ,  Y02A50/58

Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20170044252A1

公开(公告)日：2017-02-16

申请号：US15337512

申请日：2016-10-28

Applicant: Janssen Biotech, Inc.

Inventor： Jacqueline Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill Giles-Komar ,  Jinquan Luo ,  Michael Rycyzyn ,  Raymond Sweet

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: A61K39/3955 ,  A61K39/00 ,  A61K45/06 ,  A61K2039/505 ,  A61K2039/55527 ,  A61K2039/55544 ,  C07K16/244 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/55 ,  G01N33/6869 ,  G01N2333/54 ,  Y02A50/386 ,  Y02A50/401 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/55 ,  Y02A50/57 ,  Y02A50/58

Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 抗IL-23抗体，包括编码至少一种抗IL-23抗体，载体，宿主细胞，转基因动物或植物的分离的核酸及其制备和使用的方法具有诊断和/或治疗组合物中的应用 ，方法和设备。

公开(公告)号：US10576150B2

公开(公告)日：2020-03-03

申请号：US16358775

申请日：2019-03-20

Applicant: Janssen Biotech, Inc.

Inventor： Jacqueline Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill Giles-Komar ,  Jinquan Luo ,  Michael Rycyzyn ,  Raymond Sweet

IPC: A61K39/395 ,  G01N33/68 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20190201527A1

公开(公告)日：2019-07-04

申请号：US16358775

申请日：2019-03-20

Applicant: Janssen Biotech, Inc.

Inventor： Jacqueline Benson ,  Mark Cunningham ,  Cynthia Duchala ,  Jill Giles-Komar ,  Jinquan Luo ,  Michael Rycyzyn ,  Raymond Sweet

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  G01N33/68

Abstract: An anti-IL-23 antibody, including isolated nucleic acids that encode at least one anti-IL-23 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US09862766B2

公开(公告)日：2018-01-09

申请号：US15432636

申请日：2017-02-14

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K38/20 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US09828424B2

公开(公告)日：2017-11-28

申请号：US15075248

申请日：2016-03-21

Applicant: Janssen Biotech, Inc.

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K9/19 ,  A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  A61K38/27 ,  A61K45/06 ,  C07K16/42 ,  G01N33/566 ,  A61K39/00

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

公开(公告)号：US20140178295A1

公开(公告)日：2014-06-26

申请号：US14190893

申请日：2014-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。

公开(公告)号：US20140141013A1

公开(公告)日：2014-05-22

申请号：US14167384

申请日：2014-01-29

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Mohit Trikha

IPC: C07K16/24

CPC classification number: C07K16/248 ,  A01K67/0271 ,  A01K2267/0331 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/4241 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  A61K2300/00

Abstract: The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及至少一种衍生自鼠CLB-8抗体的新型嵌合，人源化或CDR移植的抗IL-6抗体，包括编码至少一种这样的抗IL-6抗体的分离的核酸，载体， 宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。