公开(公告)号：US09862766B2

公开(公告)日：2018-01-09

申请号：US15432636

申请日：2017-02-14

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K38/20 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US09828424B2

公开(公告)日：2017-11-28

申请号：US15075248

申请日：2016-03-21

Applicant: Janssen Biotech, Inc.

Inventor： George Heavner ,  David M. Knight ,  Jill Giles-Komar ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K9/19 ,  A61K39/395 ,  A61K38/18 ,  A61K38/19 ,  A61K38/27 ,  A61K45/06 ,  C07K16/42 ,  G01N33/566 ,  A61K39/00

CPC classification number: C07K16/241 ,  A61K9/19 ,  A61K38/1816 ,  A61K38/19 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/42 ,  C07K16/4241 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/566 ,  Y02A50/386 ,  Y02A50/412 ,  Y10S514/825 ,  Y10S514/826

Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.

公开(公告)号：US20140178295A1

公开(公告)日：2014-06-26

申请号：US14190893

申请日：2014-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。

公开(公告)号：US20130129617A1

公开(公告)日：2013-05-23

申请号：US13669894

申请日：2012-11-06

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K38/19 ,  A61K38/27 ,  A61K51/00 ,  A61K31/137 ,  A61K39/395 ,  A61K31/56

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriatic arthritis.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其应用具有治疗IL-12相关疾病如牛皮癣关节炎的应用。

公开(公告)号：US20190085069A1

公开(公告)日：2019-03-21

申请号：US16209326

申请日：2018-12-04

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  C07K14/54 ,  A61K45/06 ,  A61K39/395 ,  A61K38/27 ,  A61K31/56 ,  A61K31/137 ,  A61K51/00 ,  C12Q1/6876 ,  A61K39/00

Abstract: An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody or fragment thereof, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20180334500A1

公开(公告)日：2018-11-22

申请号：US15583487

申请日：2017-05-01

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

公开(公告)号：US09409984B2

公开(公告)日：2016-08-09

申请号：US14190893

申请日：2014-02-26

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.

Abstract translation: 分离的抗IL-12抗体，编码抗体或抗体部分的核酸，载体，宿主细胞和制备方法可用于产生用于治疗和/或诊断IL-12相关病症，疾病和障碍的抗体或部分， 如牛皮癣。

公开(公告)号：US11078267B2

公开(公告)日：2021-08-03

申请号：US16677120

申请日：2019-11-07

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.

公开(公告)号：US20190248884A1

公开(公告)日：2019-08-15

申请号：US16284316

申请日：2019-02-25

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K39/395 ,  A61K45/06

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as systemic lupus erythematosus.

公开(公告)号：US10259867B2

公开(公告)日：2019-04-16

申请号：US15583487

申请日：2017-05-01

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  David M. Knight ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K45/06 ,  A61K39/00

Abstract: Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriasis.