公开(公告)号：US20130239238A1

公开(公告)日：2013-09-12

申请号：US13804357

申请日：2013-03-14

Applicant: JANSSEN BIOTECH, INC.

Inventor： Robert Jordan ,  David Knight ,  Randall Brezski ,  Mary Ryan ,  Diane Petrone

IPC: C07K16/42 ,  C07K7/08

CPC classification number: C07K16/42 ,  A61K2039/505 ,  A61K2039/507 ,  C07K7/08 ,  C07K16/065 ,  C07K16/2848 ,  C07K16/36 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/6854 ,  G01N33/6857

Abstract: The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.

Abstract translation: 本发明涉及抗体组合物和该组合物用于检测与精制蛋白酶相关的疾病过程的用途。 试剂用于评估作为这种蛋白水解切割结果的IgG分解产物。 本发明还涉及用于IgG蛋白酶切割产物的治疗免疫特异性用于恢复经受蛋白酶切割的抗体组合物的效应子功能的用途。

公开(公告)号：US20180079809A1

公开(公告)日：2018-03-22

申请号：US15830586

申请日：2017-12-04

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  C12Q1/68 ,  C07K14/54 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  A61K31/137 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody or fragment thereof, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20160319014A1

公开(公告)日：2016-11-03

申请号：US15217099

申请日：2016-07-22

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  C12Q1/68

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

公开(公告)号：US09428579B2

公开(公告)日：2016-08-30

申请号：US14512757

申请日：2014-10-13

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K45/06 ,  A61K51/00 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

公开(公告)号：US08894990B2

公开(公告)日：2014-11-25

申请号：US13669894

申请日：2012-11-06

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K39/395 ,  C07K16/24 ,  A61K31/56 ,  A61K51/00 ,  A61K31/137 ,  C07K14/54 ,  A61K38/27 ,  A61K45/06 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in treating IL-12-related disorders, such as psoriatic arthritis.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其应用具有治疗IL-12相关疾病如牛皮癣关节炎的应用。

公开(公告)号：US20170157247A1

公开(公告)日：2017-06-08

申请号：US15432636

申请日：2017-02-14

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K51/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US09605067B2

公开(公告)日：2017-03-28

申请号：US15217099

申请日：2016-07-22

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C12N5/10 ,  C12N15/24 ,  C12N15/63 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US20150030608A1

公开(公告)日：2015-01-29

申请号：US14512757

申请日：2014-10-13

Applicant: JANSSEN BIOTECH, INC.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  A61K45/06 ,  A61K39/395

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

Abstract translation: 结合IL-12蛋白的一部分对应于至少一个氨基酸残基的抗IL-12抗体，其选自残基15,17-21,23,40-43,45-47,54 -56和58-62的IL-12的p40亚基的氨基酸序列，包括编码至少一种抗IL-12抗体，载体，宿主细胞，转基因动物或植物的分离的核酸，以及制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。

公开(公告)号：US20190085069A1

公开(公告)日：2019-03-21

申请号：US16209326

申请日：2018-12-04

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: C07K16/24 ,  C07K14/54 ,  A61K45/06 ,  A61K39/395 ,  A61K38/27 ,  A61K31/56 ,  A61K31/137 ,  A61K51/00 ,  C12Q1/6876 ,  A61K39/00

Abstract: An anti-IL-12 antibody or fragment thereof that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody or fragment thereof, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

公开(公告)号：US09862766B2

公开(公告)日：2018-01-09

申请号：US15432636

申请日：2017-02-14

Applicant: Janssen Biotech, Inc.

Inventor： Jill Giles-Komar ,  George Heavner ,  David Knight ,  Jinquan Luo ,  David Peritt ,  Bernard Scallon ,  David Shealy

IPC: A61K38/20 ,  C07K16/24 ,  C07K14/54 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/395 ,  A61K45/06 ,  A61K51/00 ,  C12Q1/68 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K31/137 ,  A61K31/56 ,  A61K38/27 ,  A61K39/3955 ,  A61K45/06 ,  A61K51/00 ,  A61K2039/505 ,  C07K14/54 ,  C07K14/5434 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/76 ,  C12Q1/6876

Abstract: An anti-IL-12 antibody that binds to a portion of the IL-12 protein corresponding to at least one amino acid residue selected from the group consisting of residues 15, 17-21, 23, 40-43, 45-47, 54-56 and 58-62 of the amino acid sequence of the p40 subunit of IL-12, including isolated nucleic acids that encode at least one anti-IL-12 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.