公开(公告)号：US07816124B2

公开(公告)日：2010-10-19

申请号：US11432616

申请日：2006-05-12

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: C12M1/34

CPC classification number: A61B5/14546 ,  A61B5/14557 ,  A61B5/150022 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150236 ,  A61B5/150244 ,  A61B5/150251 ,  A61B5/150343 ,  A61B5/150351 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150755 ,  A61B5/150992

Abstract: An apparatus suitable for measuring at least one plasma analyte in plasma extracted from a whole blood sample within the apparatus is provided. The apparatus can be adapted for insertion into a slot in a meter, which can preferably perform at least spectroscopic or biosensor measurement. The apparatus comprises a whole blood flow path, which begins at the inlet opening of the apparatus, and terminates at a vent or a suction chamber. Included in the blood flow path is a flow-through filtration chamber. The filtration chamber comprises at least one membrane separating a blood compartment from a plasma compartment. The apparatus further comprises a plasma flow path, which begins at the plasma compartment and terminates at a vent or a suction chamber. The plasma flow path includes a plasma analyte signal providing means. The signal is transmitted to a processor in the meter for preparing analyte measurements.

Abstract translation: 提供一种适用于测量从装置内的全血样品中提取的血浆中至少一种血浆分析物的装置。 该装置可以适于插入仪表中的槽中，其可以优选地至少执行光谱或生物传感器测量。 该装置包括从装置的入口开始的终止于通气口或吸入室的全血流路径。 血流路径中包括流通过滤室。 过滤室包括将血液隔室与等离子体隔室分开的至少一个膜。 该装置还包括等离子体流动通道，该等离子体流动路径在等离子体隔间开始并终止于通风口或吸入室。 等离子体流动路径包括等离子体分析物信号提供装置。 信号被传送到仪表中的处理器，用于制备分析物测量。

公开(公告)号：US07740804B2

公开(公告)日：2010-06-22

申请号：US12016315

申请日：2008-01-18

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: G01N21/11

CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L3/502746 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2400/0406 ,  G01N21/03 ,  G01N21/11 ,  G01N21/274 ,  G01N33/49 ,  G01N2021/0314 ,  G01N2021/0346 ,  G01N2021/0382

Abstract: Some embodiments of the present invention provide a sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells using sound waves or reagents. The inlet of some embodiments of the sample holder is a piece of capillary tube, and in other embodiments, the inlet is configured to engage a syringe. In some embodiments, the inlet of the sample holder can accommodate adaptors with different configurations, thereby allowing the sample holder to receive blood from any source, for example a pin prick or a syringe.

Abstract translation: 本发明的一些实施方案提供了适合于血液样品的收集和光谱测量的样品保持器。 在一些实施例中，样品保持器设置有专门设计用于将血液分散到薄膜中的光学室，从而减少由于血液样品中的红细胞的EMR散射引起的电磁辐射（EMR）的平均衰减 ，而不必使用声波或试剂溶血红细胞。 样品保持器的一些实施例的入口是一片毛细管，并且在其它实施例中，入口构造成接合注射器。 在一些实施例中，样品保持器的入口可以容纳具有不同构型的适配器，从而允许样品保持器从任何来源例如针刺或注射器接收血液。

公开(公告)号：US07638342B2

公开(公告)日：2009-12-29

申请号：US10590431

申请日：2005-02-24

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: G01N1/18 ,  G01N33/48 ,  G01N33/49 ,  G01N1/28 ,  G01N21/07 ,  G01N21/25

CPC classification number: G01N21/31 ,  B01L3/5021 ,  G01N33/491 ,  Y10T436/111666 ,  Y10T436/25 ,  Y10T436/25375

Abstract: The present invention provides a method of analyzing plasma from a sample of whole blood. The method includes a) obtaining a sample of whole blood from a subject in a container, the container having a first end and a second end, the first end of the container for receiving a sample of whole blood; b) centrifuging the container under conditions to separate the whole blood into a cell layer, a gel layer and a plasma layer, wherein the centrifuging produces in relative juxtaposition the first end of the container, the cell layer, the gel layer, the plasma layer and the second end of the container; and c) inserting into a spectrophotometric device the second end of the container which includes the plasma layer in closest relative juxtaposition, to analyze the plasma from the whole blood.

Abstract translation: 本发明提供了从全血样品中分析血浆的方法。 该方法包括：a）从容器中得到来自受试者的全血样品，该容器具有第一端和第二端，容器的第一端用于接收全血样品; b）在将全血分离成细胞层，凝胶层和等离子体层的条件下离心容器，其中离心分离产生容器的第一端，细胞层，凝胶层，等离子体层 和容器的第二端; 以及c）将包含最近相对并置的等离子体层的容器的第二端插入分光光度计，以分析来自全血的血浆。

公开(公告)号：US20070232995A1

公开(公告)日：2007-10-04

申请号：US11738889

申请日：2007-04-23

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: A61M31/00 ,  A61M5/32

CPC classification number: A61B5/150587 ,  A61B5/15003 ,  A61B5/150213 ,  A61B5/150251 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150641 ,  A61B5/150717 ,  A61B5/150755 ,  A61B5/153

Abstract: Some embodiments of the invention provide a needle comprising a shaft with a sharp open end and a hub with a blunt open end, housed in a barrel with an open anterior end and an open posterior end. The hub of the needle can move forward inside the barrel, for extending the sharp open end of the shaft of the needle for insertion into a vessel, e.g. a blood vessel, a catheter, or a capped tube. After use, the hub can move backwards inside the barrel for retracting the shaft of the needle into the barrel. The blunt open end of the needle can be fluidly connected to the inlet opening of a measurement apparatus, so that the blood can flow directly from a vessel, into the measurement apparatus, without the use of a syringe. The hollow needle assembly can also be used with a traditional syringe, as an alternative to traditional needles, in order to minimize the risk of needle-stick injury.

Abstract translation: 本发明的一些实施例提供了一种针，其包括具有尖锐开口端的轴和具有钝开口端的毂，该针头容纳在具有开放前端和敞开后端的筒中。 针的毂可以在筒内向前移动，用于延伸针的轴的锋利的开口端，以插入到容器中，例如， 血管，导管或封盖管。 使用后，轮毂可以在筒内向后运动，以将针的轴缩回到筒内。 针的平头开口端可以流体地连接到测量装置的入口，使得血液可以直接从血管流入测量装置，而不使用注射器。 中空针组件也可以与传统的注射器一起使用，作为传统针的替代，以便最小化针刺伤害的风险。

公开(公告)号：US20050170522A1

公开(公告)日：2005-08-04

申请号：US10981765

申请日：2004-11-05

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: B01L3/00 ,  G01N21/03 ,  G01N21/11 ,  G01N31/22

CPC classification number: B01L3/508 ,  B01L2200/0605 ,  B01L2300/043 ,  G01N21/03 ,  G01N21/11

Abstract: A sample tab for retaining a sample during spectroscopic analysis includes a base plate, a sample well, and a cover plate. The sample well may vary in size to accommodate different sample volumes, and the base of the sample well may be positioned above or below the plane of the base plate. The walls of the sample well may also include one, or more than one overflow opening for draining excess sample, and an overflow channel to retain the excess sample.

Abstract translation: 用于在光谱分析过程中保留样品的样品片包括底板，样品孔和盖板。 样品孔的尺寸可以变化以适应不同的样品体积，并且样品阱的基底可以位于基板的平面的上方或下方。 样品阱的壁还可以包括一个或多于一个用于排出多余样品的溢流开口和用于保留多余样品的溢流通道。

公开(公告)号：US06711516B2

公开(公告)日：2004-03-23

申请号：US09875143

申请日：2001-06-07

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: G06F1900

CPC classification number: G01N21/4785 ,  G01N21/274

Abstract: Described is a method for calibrating a spectrophotometric apparatus. This method involves obtaining a first set of absorbance measurements of a set of calibrators on a First Apparatus that is in control at wavelengths from a first wavelength calibration table. A second wavelength calibration table on a second apparatus is established, wherein the first and the second wavelength calibration tables may be the same or different. A second set of absorbance measurements of the set of calibrators is obtained on the Second Apparatus, at wavelengths from the second wavelength calibration table. First and second interpolated absorbances are determined, for the first and the second absorbance measurement, respectively, for at least one wavelength of a Standard Set of Wavelengths. Using the first and the second interpolated absorbances, a linear regression equation for each wavelength of said Standard Set of Wavelengths is determined. The linear regression equation and at least one Primary Calibration Algorithm are incorporated onto the Second Apparatus, to produce a calibrated apparatus. The present invention is also directed to a medium storing instructions adapted to be executed by a processor to determine analyte concentration within a sample. Furthermore, the present invention provides an apparatus for determining analyte concentration of a sample, and a system for determining presence of an analyte in a sample.

Abstract translation: 描述了用于校准分光光度仪的方法。 该方法包括在第一设备上获得一组校准器的第一组吸光度测量值，该第一设备在来自第一波长校准表的波长处被控制。 建立在第二装置上的第二波长校准表，其中第一和第二波长校准表可以相同或不同。 在第二装置上，在来自第二波长校准表的波长处获得该组校准器的第二组吸光度测量。 对于第一和第二吸光度测量，分别对于标准波长组的至少一个波长确定第一和第二内插吸光度。 使用第一和第二内插吸光度，确定所述标准波长组的每个波长的线性回归方程。 将线性回归方程和至少一个主校准算法合并到第二装置上，以产生校准装置。 本发明还涉及一种存储适于由处理器执行以确定样品中的分析物浓度的指令的介质。 此外，本发明提供了一种用于确定样品的分析物浓度的装置，以及用于确定样品中分析物的存在的系统。

公开(公告)号：US5846492A

公开(公告)日：1998-12-08

申请号：US815451

申请日：1997-03-11

Applicant: Merrit Nyles Jacobs ,  Davis Freeman, III ,  James David Shaw ,  James Samsoondar ,  Thomas Moffett

Inventor： Merrit Nyles Jacobs ,  Davis Freeman, III ,  James David Shaw ,  James Samsoondar ,  Thomas Moffett

IPC: G01N21/03 ,  G01N35/00 ,  G01N35/10 ,  G01N21/01

CPC classification number: G01N21/03 ,  G01N35/00029 ,  G01N35/10 ,  G01N2035/1062 ,  Y10T436/11 ,  Y10T436/112499 ,  Y10T436/114998 ,  Y10T436/115831 ,  Y10T436/119163 ,  Y10T436/25 ,  Y10T436/2575

Abstract: Apparatus and method for detecting patient sample quality, and/or analytes, in the tip used to aspirate the patient sample liquid and then dispense it onto a slide test element. Spectrophotometric analysis is done on the liquid while still in the tip, by scanning the tip for transmittance in a light-tight enclosure, using NIR and adjacent visible radiation, and detecting the absorbence spectra of the liquid. Much smaller liquid volumes, and no through-the-label detection, are required, compared to doing the scanning of the liquid in a primary patient collection container.

Abstract translation: 用于检测患者样品质量的装置和方法，和/或分析物，用于抽吸患者样品液体的尖端，然后将其分配到载玻片测试元件上。 通过使用NIR和相邻的可见光辐射扫描尖端以在不透光的外壳中进行透射，并检测液体的吸收光谱，对液体进行分光光度分析。 与在初级患者收集容器中进行液体扫描相比，需要更小的液体体积和无标签检测。

公开(公告)号：US20100245803A1

公开(公告)日：2010-09-30

申请号：US12813207

申请日：2010-06-10

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: G01N33/48

CPC classification number: B01L3/502715 ,  B01L3/502723 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0688

Abstract: Some embodiments of the invention provide one sample holder that is suitable for collection and spectroscopic measurement of a blood sample. In some very specific embodiments, the sample holder is provided with an optical chamber that is specifically designed to spread blood into a thin film, thereby reducing the average attenuation of electromagnetic radiation (EMR) due to scattering of EMR by the red blood cells in a blood sample, without having to hemolyze the red blood cells. Also, the sample holder is designed so that air bubbles are easily pushed through the optical chamber and guided out of the sample holder through a vent. In some embodiments, the inlet of the sample holder can be reconfigured with adaptors to receive blood from for example, a pin prick or a syringe. Use of adaptors makes the housing simpler when considering the manufacturing process.

Abstract translation: 本发明的一些实施方案提供了适合于血样的收集和光谱测量的一个样品保持器。 在一些非常具体的实施例中，样品保持器设置有专门设计用于将血液分散到薄膜中的光学室，从而减少由于红细胞在EMR中散射的电磁辐射（EMR）的平均衰减 血液样本，而不必溶血红细胞。 此外，样品保持器被设计成使得气泡容易地被推入光学室并且通过通风口从样品保持器引出。 在一些实施例中，样品保持器的入口可以用适配器重新配置以从例如针刺或注射器接收血液。 考虑制造过程时，使用适配器可使外壳更简单。

公开(公告)号：US07108833B2

公开(公告)日：2006-09-19

申请号：US10981765

申请日：2004-11-05

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: B01L3/00

CPC classification number: B01L3/508 ,  B01L2200/0605 ,  B01L2300/043 ,  G01N21/03 ,  G01N21/11

Abstract: A sample tab for retaining a sample during spectroscopic analysis includes a base plate, a sample well, and a cover plate. The sample well may vary in size to accommodate different sample volumes, and the base of the sample well may be positioned above or below the plane of the base plate. The walls of the sample well may also include one, or more than one overflow opening for draining excess sample, and an overflow channel to retain the excess sample.

Abstract translation: 用于在光谱分析过程中保留样品的样品片包括底板，样品孔和盖板。 样品孔的尺寸可以变化以适应不同的样品体积，并且样品阱的基底可以位于基板的平面的上方或下方。 样品阱的壁还可以包括一个或多于一个用于排出多余样品的溢流开口和用于保留多余样品的溢流通道。

公开(公告)号：US06949384B2

公开(公告)日：2005-09-27

申请号：US10136329

申请日：2002-05-02

Applicant: James Samsoondar

Inventor： James Samsoondar

IPC: G01N33/72

CPC classification number: G01N33/72

Abstract: The present invention provides a method for monitoring degradation of Hb-based blood substitutes, in a sample. This method involves determining a concentration of met-Hb within the sample, by applying a calibration algorithm for met-Hb to an absorbance obtained from the sample at one or more than one wavelengths, and using the concentration of met-Hb, as a measurement of degradation of the Hb-based blood substitutes. Using this assay, a concentration of met-Hb that is equal to or greater than 3% may be used as an indicator of degradation of Hb. Alternatively, by obtaining samples over a period of time, the concentration of met-Hb and the concentration of Hb-based blood substitute may be determined in each of these samples, and an increase in the concentration of met-Hb over the period of time is an indicator of degradation of Hb. The sample may be a whole blood sample, a serum sample, or a plasma sample obtained from a patient transfused with one or more than one Hb-based blood substitutes, a stock Hb-based blood substitute sample, or a body part of a patient.

Abstract translation: 本发明提供一种用于监测样品中Hb基血液代用品降解的方法。 该方法包括测定样品中的met-Hb的浓度，通过将met-Hb的校准算法应用于从一个或多于一个波长的样品获得的吸光度，并使用met-Hb的浓度作为测量 的Hb型血液代用品的降解。 使用该测定，可以使用等于或大于3％的met-Hb的浓度作为Hb降解的指标。 或者，通过在一段时间内获得样品，可以在这些样品中的每一个中确定met-Hb的浓度和基于Hb的血液替代物的浓度，并且在一段时间内met-Hb的浓度增加 是Hb降解的指标。 样品可以是从输入一种或多种基于Hb的血液代用品，基于Hb的血液替代品样品或患者的身体部位输入的患者获得的全血样品，血清样品或血浆样品 。