公开(公告)号：US20100099574A1

公开(公告)日：2010-04-22

申请号：US12644255

申请日：2009-12-22

Applicant: JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

Inventor： JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

IPC: C40B20/02

CPC classification number: G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

Abstract: A method of identifying an analyte. The method includes providing a plurality of microparticles. The microparticles have optically detectable codes extending along bodies of the corresponding microparticle. The microparticles have the chemical probes attached thereto. Each of the chemical probes is associated with a corresponding one of the codes. The method also includes selectively binding target analytes to the chemical probes on the microparticles to produce labeled microparticles and distributing the labeled microparticles to random locations of a substrate. The method also includes determining the codes for the labeled microparticles in the random array and code positions of the codes in the random array. The method further includes detecting the label on the labeled microparticles in the random array and label positions of the labels in the random array. The method also includes using the code positions and the label positions to analyze the target analyte.

Abstract translation: 识别分析物的方法。 该方法包括提供多个微粒。 微粒具有沿相应微粒的主体延伸的光学检测码。 微粒具有附着于其上的化学探针。 每个化学探针与相应的一个代码相关联。 该方法还包括将目标分析物选择性地结合到微粒上的化学探针以产生标记的微粒并将标记的微粒分布到基底的随机位置。 该方法还包括确定随机阵列中的标记微粒的代码和随机阵列中代码的代码位置。 该方法还包括随机阵列中标记的微粒上的标记和随机阵列中的标记的标记位置的检测。 该方法还包括使用代码位置和标签位置来分析目标分析物。

公开(公告)号：US20090194589A1

公开(公告)日：2009-08-06

申请号：US12174490

申请日：2008-07-16

Applicant: JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

Inventor： JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

IPC: G06K7/10

CPC classification number: G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

Abstract: An optical reader system that includes a plurality of substrates. The substrates have an optically readable code disposed therein and a source light assembly that is configured to illuminate the substrates with a code-reading beam and another beam for detecting another optically readable property of the substrate. The code-reading beam and the other beam form beam spots on the substrates that have different shapes. The system also includes a reader that is configured to receive output signals from the code-reading beam and the other beam when the substrates are illuminated. The output signals from the code-reading beam are indicative of the code.

Abstract translation: 一种包括多个基板的光学读取器系统。 基板具有设置在其中的光学可读代码，以及源光组件，其被配置为用代码读取光束照射基板，另一个光束用于检测基板的另一光学可读性。 代码读取光束和另一个光束在具有不同形状的基板上形成光束点。 该系统还包括读取器，其被配置为当基板被照亮时从代码读取光束和另一个光束接收输出信号。 代码读取波束的输出信号表示代码。

公开(公告)号：US20110114729A1

公开(公告)日：2011-05-19

申请号：US13014298

申请日：2011-01-26

Applicant: JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

Inventor： JOHN A. MOON ,  DAVID R. FOURNIER ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  TUO LI

IPC: G06K7/14

CPC classification number: G06K7/12 ,  G06K19/06084 ,  G06K19/06178 ,  G06K2019/06225

Abstract: An optical reader system including a source light assembly that has a code-reading beam and a fluorescence-excitation beam that are configured to illuminate encoded substrates. The substrates have optically readable codes that provide output signals when the code-reading beam is incident thereon. The output signals are indicative of the codes. The reader system also includes a fluorescence detector that is configured to detect fluorescent signals from the substrates and code pickup optics that are configured to project the output signals from the optically readable codes onto a Fourier plane. The reader system also includes a code detector that is positioned to detect the output signals in the Fourier plane.

Abstract translation: 一种光学读取器系统，包括具有代码读取光束的源光组件和被配置为照亮编码的基板的荧光激发光束。 衬底具有光学可读代码，当代码读取光束入射时，其提供输出信号。 输出信号表示代码。 读取器系统还包括荧光检测器，其被配置为检测来自基板的荧光信号和被配置为将来自光学可读代码的输出信号投影到傅立叶平面上的代码拾取光学器件。 读取器系统还包括代码检测器，其被定位成检测傅立叶平面中的输出信号。

公开(公告)号：US20110058172A1

公开(公告)日：2011-03-10

申请号：US12941568

申请日：2010-11-08

Applicant: JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

Inventor： JOHN A. MOON ,  ALAN D. KERSEY ,  MARTIN A. PUTNAM ,  TUO LI

IPC: G01N21/25

CPC classification number: G01N33/552 ,  G01N21/4788 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6452 ,  G01N21/7743 ,  G01N33/54306 ,  G01N33/54313 ,  G01N33/54366 ,  G01N33/54386 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/0236 ,  G03H1/26 ,  G03H2001/0033 ,  G03H2001/0044 ,  G03H2210/53 ,  G03H2210/63 ,  G03H2230/10 ,  G03H2250/12 ,  G06K19/04 ,  G06K19/06009

Abstract: A method of identifying analytes that react with probes on encoded particles. The method includes providing a support substrate that has a plurality of the particles randomly distributed on the support substrate. The particles have elongated bodies with codes that extend along the corresponding bodies. The codes identify probes that are attached to the corresponding bodies, wherein at least some of the probes include fluorescent labels from reactions with the analytes. The method also includes detecting fluorescent signals that are emitted from the fluorescent labels. The fluorescent signals emit from random spatial locations along the support substrate. The method also includes detecting the codes of the particles at the random spatial locations along the support substrate and analyzing the codes and the fluorescent signals to identify the analytes that react with the probes on the particles.

Abstract translation: 识别与编码粒子上的探针反应的分析物的方法。 该方法包括提供具有随机分布在支撑衬底上的多个颗粒的支撑衬底。 颗粒具有细长体，其具有沿相应体部延伸的代码。 代码识别附着于相应体的探针，其中至少一些探针包括与分析物反应的荧光标记。 该方法还包括检测从荧光标记物发射的荧光信号。 荧光信号沿着支撑衬底从随机空间位置发射。 该方法还包括沿着支撑衬底的随机空间位置检测颗粒的代码并分析代码和荧光信号以识别与颗粒上的探针反应的分析物。

公开(公告)号：US20100246007A1

公开(公告)日：2010-09-30

申请号：US12559304

申请日：2009-09-14

Applicant: JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  DAVID FOURNIER ,  JOSEPH PINTO

Inventor： JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  DAVID FOURNIER ,  JOSEPH PINTO

IPC: G02B5/18 ,  H03M1/22 ,  G06K5/00

CPC classification number: G06K19/06009 ,  G03H1/0011 ,  G03H2001/0016 ,  G06K19/16 ,  G06K2019/0629 ,  G07D7/0032 ,  G07D7/128

Abstract: A method and apparatus for drug product tracking (or other pharmaceutical, health care or cosmetics products, and/or the packages or containers they are supplied with) using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or more collocated pitches Λ which represent a unique identification digital code that is detected when illuminated by incident light 24. The incident light 24 may be directed transversely from the side of the substrate 10 (or from an end) with a narrow band (single wavelength) or multiple wavelength source, and the code is represented by a spatial distribution of light or a wavelength spectrum, respectively, or a combination thereof. The encoded element 8 may be used to label any desired item, such as drugs or medicines, or other pharmaceutical or health care products or cosmetics. The label may be used for many different purposes, such as for sorting, tracking, identification, verification, authentication, anti-theft/anti-counterfeit, security/anti-terrorism, or for other purposes. In a manufacturing environment, the elements 8 may be used to track inventory for production information or sales of goods/products. Such labeling provides product identification at the pill or liquid medicine level, which provides traceability of these products to their manufacturer, thereby reducing counterfeit products in the marketplace. Also, the elements 8 may be incorporated into a film, liquid, coating or adhesive tape at attached to the product package.

Abstract translation: 使用基于衍射光栅的编码光学识别元件8的药物追踪（或其他药物，保健或化妆品产品和/或其提供的包装或容器）的方法和装置包括具有至少一个 设置在其中的衍射光栅12。 光栅12具有一个或多个并置的间距Λ，它们表示当被入射光24照射时被检测到的唯一识别数字码。入射光24可以从基板10的一侧（或从一端）横向引导到 窄波段（单波长）或多波长光源，代码分别由光或波长光谱的空间分布或其组合表示。 编码元件8可以用于标记任何期望的物品，例如药物或药物，或其它药物或保健产品或化妆品。 该标签可用于许多不同的目的，例如用于分类，跟踪，识别，验证，认证，防盗/防伪，安全/反恐，或用于其他目的。 在制造环境中，元件8可用于跟踪生产信息的库存或货物/产品的销售。 这种标签在药丸或液体药物级别提供产品鉴定，这些产品可以向制造商提供可追溯性，从而减少市场上的假冒产品。 此外，元件8可以结合到附接到产品包装上的膜，液体，涂层或胶带中。

公开(公告)号：US20100025482A1

公开(公告)日：2010-02-04

申请号：US12559652

申请日：2009-09-15

Applicant: JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  PAUL SZCZEPANEK

Inventor： JOHN A. MOON ,  MARTIN A. PUTNAM ,  ALAN D. KERSEY ,  PAUL SZCZEPANEK

IPC: G06K19/06

CPC classification number: G03H5/00 ,  G01N23/2005 ,  G03H2001/0016 ,  G07D7/003

Abstract: A composition including an item and an optical identification element that is physically associated with the item. The optical identification element includes a binder material and one or more materials embedded in the binder material. The one or more materials provides a composite X-ray diffraction pattern when illuminated by an X-ray beam. The composite X-ray diffraction pattern being indicative of a code. The code relating to information about the item.

Abstract translation: 一种组合物，其包括与所述物品物理相关联的物品和光学识别元件。 光学识别元件包括粘合剂材料和嵌入粘合剂材料中的一种或多种材料。 一种或多种材料在由X射线束照射时提供复合X射线衍射图案。 复合X射线衍射图表示代码。 有关该项目信息的代码。

公开(公告)号：US20090073520A1

公开(公告)日：2009-03-19

申请号：US12235834

申请日：2008-09-23

Applicant: ALAN D. KERSEY ,  JOHN A. MOON ,  MARTIN A. PUTNAM

Inventor： ALAN D. KERSEY ,  JOHN A. MOON ,  MARTIN A. PUTNAM

IPC: G03H1/00 ,  B29D11/00

CPC classification number: G03F7/001 ,  G02B5/1857 ,  G02B5/203 ,  G03H1/18 ,  G03H1/182 ,  G03H2230/10 ,  Y10S359/90 ,  Y10T428/2982 ,  Y10T428/2991 ,  Y10T436/143333

Abstract: A method for fabricating microparticles is provided. The method includes providing a removable substrate that has a photosensitive material. The substrate has a plurality of inner regions. Each inner region surrounds a corresponding outer region. The method also includes providing at least one optically detectable code within at least one of the inner regions of the substrate and etching lines into the substrate to create a plurality of microparticles having at least one optically detectable code therein. The microparticles have elongated bodies that extend in an axial direction. The optically detectable codes extend in the axial direction within the microparticles.

Abstract translation: 提供了制造微粒的方法。 该方法包括提供具有感光材料的可移除基底。 衬底具有多个内部区域。 每个内部区域围绕相应的外部区域。 该方法还包括在衬底的内部区域中的至少一个内部提供至少一个可光学检测的代码，并将蚀刻线蚀刻到衬底中以产生其中具有至少一个光学可检测代码的多个微粒。 微粒具有沿轴向延伸的细长体。 可光学检测的代码沿着微粒内的轴向延伸。

公开(公告)号：US20120074225A1

公开(公告)日：2012-03-29

申请号：US13243422

申请日：2011-09-23

Applicant: JOHN A. MOON ,  MARTIN A. PUTNAM

Inventor： JOHN A. MOON ,  MARTIN A. PUTNAM

IPC: G06K7/10

CPC classification number: G06K7/10821 ,  B01J2219/00459 ,  B01J2219/005 ,  B01J2219/00704 ,  B82Y20/00 ,  G01N15/1468 ,  G02B1/005 ,  G06E3/005 ,  G06K7/10722

Abstract: An optical system for reading encoded microbeads. The microbeads provide output light signals onto a Fourier plane when illuminated by an incident light. The system includes an input light source that is configured to illuminate the microbeads thereby providing the output light signals. The output light signals are configured to be projected onto the Fourier plane in a readable manner. The system also includes a reading device that is positioned to detect the output light signals from the Fourier plane. The system also includes a processor that is configured to perform Fourier plane analysis of the optical light signals to determine corresponding codes of the microbeads.

Abstract translation: 用于读取编码微珠的光学系统。 当由入射光照射时，微珠将输出光信号提供到傅立叶平面上。 该系统包括被配置为照亮微珠从而提供输出光信号的输入光源。 输出光信号被配置为以可读方式投影到傅立叶平面上。 该系统还包括读取装置，其被定位成检测来自傅里叶平面的输出光信号。 该系统还包括处理器，其被配置为对光信号进行傅立叶平面分析以确定微珠的相应代码。

公开(公告)号：US20110105361A1

公开(公告)日：2011-05-05

申请号：US12916242

申请日：2010-10-29

Applicant: JOHN A. MOON ,  M. SHANE BOWEN ,  RYAN C. SMITH ,  MICHEL PERBOST ,  MICHAL LEBL ,  STEVEN H. MODIANO

Inventor： JOHN A. MOON ,  M. SHANE BOWEN ,  RYAN C. SMITH ,  MICHEL PERBOST ,  MICHAL LEBL ,  STEVEN H. MODIANO

IPC: C40B30/10 ,  C40B40/00

CPC classification number: G01N33/50 ,  B01J19/0046 ,  B01J2219/00306 ,  B01J2219/00511 ,  B01J2219/0052 ,  B01J2219/00524 ,  B01J2219/00545 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00673 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/502761 ,  B01L3/5082 ,  B01L3/50857 ,  B01L3/5088 ,  B01L3/545 ,  C40B20/04 ,  G01N21/01 ,  G01N21/253 ,  G01N21/6452 ,  G01N35/00732

Abstract: A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.

Abstract translation: 读取用于生物或化学分析的测定中使用的多个编码微血管的方法。 该方法可以包括提供多个编码微血管。 微血管可以包括相应的微体和被配置为将物质保持在储存器芯中的储存器芯。 微体可以包括围绕储存器芯的材料，并且有助于检测储存器芯内物质的特性。 任选地，材料可以是透明的，以便于检测储存器芯内的物质的光学特性。 微体可以包括与物质相关联的可识别代码。 该方法还可以包括确定微血管的相应代码。

公开(公告)号：US20100157086A1

公开(公告)日：2010-06-24

申请号：US12638770

申请日：2009-12-15

Applicant: DARREN R. SEGALE ,  JOHN A. MOON ,  HONGJI REN

Inventor： DARREN R. SEGALE ,  JOHN A. MOON ,  HONGJI REN

IPC: H04N5/225 ,  G06K9/40

CPC classification number: C12Q1/6818 ,  C12Q1/6874 ,  G01B9/02063 ,  G01B11/24 ,  G01N21/6428 ,  G01N21/6458 ,  G02B21/244 ,  H04N5/23212

Abstract: A method and system are provided for controlling focus dynamically of a sample imager. The method comprises scanning a sample with an optical assembly that apportions the sample into regions based on a scan pattern. The optical assembly has a focal setting with respect to the sample. The method further comprises shifting the focal setting of the optical assembly during scanning of the sample, and detecting one or more images representative of one of the regions from the sample. The one or more images have associated degrees of focus corresponding to the focal setting of the optical assembly. The method analyzes the image(s) to obtain a focus score or scores corresponding thereto, where the focus scores represent a degree to which the optical assembly was in focus when detecting the images. The method adjusts the focus setting based on the focus score(s).

Abstract translation: 提供了一种方法和系统，用于动态地控制样本成像器的焦点。 该方法包括用基于扫描图案将样品分配到区域的光学组件扫描样品。 光学组件相对于样品具有聚焦设置。 该方法还包括在扫描样品期间移动光学组件的焦点设置，以及从样本中检测代表一个区域的一个或多个图像。 一个或多个图像具有与光学组件的焦点设置相对应的相关度的焦点。 该方法分析图像以获得对应的焦点得分或分数，其中焦点分数表示在检测图像时光学组件聚焦的程度。 该方法根据焦点得分调整焦点设置。