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    INTERVERTEBRAL DISC
    4.
    发明申请
    INTERVERTEBRAL DISC 失效

    公开(公告)号：US20080119936A1

    公开(公告)日：2008-05-22

    申请号：US11858716

    申请日：2007-09-20

    Applicant: Rita Kandel

    Inventor： Rita Kandel

    IPC: A61F2/44

    CPC classification number: A61L27/3856 ,  A61F2/28 ,  A61F2002/30678 ,  A61F2002/4435 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2310/00359 ,  A61L27/3612 ,  A61L27/3633 ,  A61L27/3817 ,  A61L2430/38

    Abstract: The present invention relates to an engineered biological material comprising or enriched for tissue of intervertebral disc; tissue derived from an engineered biological material; constructs comprising one or more tissues from an engineered biological material; methods for producing the engineered biological materials and constructs; and methods of using the engineered biological materials and constructs.

    Abstract translation: 本发明涉及包含或富集椎间盘组织的工程生物材料; 衍生自工程生物材料的组织; 包含来自工程生物材料的一种或多种组织的构建体; 用于生产工程生物材料和构建体的方法; 以及使用工程化生物材料和构建体的方法。

    RECONSTITUTED MINERALIZED CARTILAGE TISSUE
    5.
    发明申请
    RECONSTITUTED MINERALIZED CARTILAGE TISSUE 审中-公开
    重新配制的矿物质组织

    公开(公告)号：US20100068241A1

    公开(公告)日：2010-03-18

    申请号：US12507459

    申请日：2009-07-22

    Applicant: Rita Kandel

    Inventor： Rita Kandel

    IPC: A61K9/00 ,  A61P19/02

    CPC classification number: C12N5/0068 ,  A61K35/12 ,  A61K48/00 ,  A61L27/3608 ,  A61L27/3633 ,  A61L27/365 ,  A61L27/3654 ,  A61L27/3817 ,  A61L27/3847 ,  A61L27/3852 ,  A61L27/3895 ,  A61L2430/06 ,  C12N5/0655 ,  C12N2500/42 ,  C12N2533/90

    Abstract: A biological material comprising a continuous layer of cartilaginous tissue reconstituted in vitro which contains components associated with cartilage mineralization. The biological material may be cultured with a mineralizing agent to form a mineralized biological material. The mineralized biological material is characterized by having a biochemical composition and physiological organization substantially similar to the deep and contiguous calcified cartilage zones of articular cartilage found in animals in vivo. Methods for preparing the biological materials and methods of using the biological materials are described.

    Abstract translation: 一种生物材料，其包含体外重组的软骨组织的连续层，其含有与软骨矿化相关的成分。 生物材料可以与矿化剂一起培养以形成矿化生物材料。 矿化生物材料的特征在于具有与动物体内发现的关节软骨的深层和连续钙化软骨区基本相似的生化组成和生理组织。 描述了制备生物材料的方法和使用生物材料的方法。

    Intervertebral disc
    7.
    发明授权
    Intervertebral disc 失效
    椎间盘

    公开(公告)号：US08163554B2

    公开(公告)日：2012-04-24

    申请号：US11858716

    申请日：2007-09-20

    Applicant: Rita Kandel

    Inventor： Rita Kandel

    IPC: C12N5/077

    CPC classification number: A61L27/3856 ,  A61F2/28 ,  A61F2002/30678 ,  A61F2002/4435 ,  A61F2002/4445 ,  A61F2002/445 ,  A61F2310/00359 ,  A61L27/3612 ,  A61L27/3633 ,  A61L27/3817 ,  A61L2430/38

    Abstract: The present invention relates to an engineered biological material comprising or enriched for tissue of intervertebral disc; tissue derived from an engineered biological material; constructs comprising one or more tissues from an engineered biological material; methods for producing the engineered biological materials and constructs; and methods of using the engineered biological materials and constructs.

    Abstract translation: 本发明涉及包含或富集椎间盘组织的工程生物材料; 衍生自工程生物材料的组织; 包含来自工程生物材料的一种或多种组织的构建体; 用于生产工程生物材料和构建体的方法; 以及使用工程化生物材料和构建体的方法。

    Resorbable implant biomaterial made of condensed calcium phosphate particles
    9.
    发明授权
    Resorbable implant biomaterial made of condensed calcium phosphate particles 有权
    可再生的植入生物材料由冷凝磷酸钙颗粒制成

    公开(公告)号：US6077989A

    公开(公告)日：2000-06-20

    申请号：US194159

    申请日：1998-11-23

    Applicant: Rita Kandel ,  Robert Pilliar ,  Marc Grynpas

    Inventor： Rita Kandel ,  Robert Pilliar ,  Marc Grynpas

    IPC: A61F2/00 ,  A61F2/02 ,  A61F2/08 ,  A61L27/12 ,  A61L27/42 ,  A61L27/46

    CPC classification number: A61L27/425 ,  A61L27/12 ,  A61L27/46 ,  A61F2/08 ,  A61F2/0811 ,  A61F2210/0004 ,  A61F2310/00293

    Abstract: A resorbable biomaterial for implantation in humans and other animals comprises amorphous or crystalline condensed calcium phosphate of the general formula: [Ca(PO.sub.3).sub.2 ].sub.n, where n is 3 or greater and the molar ratio of Ca:P is between about 0.4 and 0.6. The condensed calcium phosphate powder can be formed as a sintered powder which is bound or consolidated to form at least part of an implantable anchor, with controlled size and amount of porosity. The condensed calcium phosphate part of anchor/implant preferably has a bone interfacing portion which is placed in juxtaposition with adjacent hard tissues when implanted in a patient, and which is characterized by interconnected pores extending from the exterior throughout the interior of the biomaterial. The condensed calcium phosphate may be used to replace hard connective tissues, or to regenerate soft connective tissues by providing a support on which soft tissue may be grown in vitro or in vivo, or to anchor soft connective tissue to bone.

    Abstract translation: PCT No.PCT / CA97 / 00331 Sec。 371日期：1998年11月23日 102（e）1998年11月23日日期PCT提交1997年5月15日PCT公布。 出版物WO97 / 45147 日期1997年12月4日用于植入人和其他动物的可吸收生物材料包括通式为[Ca（PO 3）2] n的无定形或结晶的缩合磷酸钙，其中n为3或更大，Ca：P 在约0.4和0.6之间。 冷凝的磷酸钙粉末可以形成为烧结粉末，其结合或固结以形成具有受控尺寸和孔隙率的至少一部分可植入锚固件。 锚固/植入物的冷凝磷酸钙部分优选具有骨接合部分，其在植入患者体内时与相邻的硬组织并置放置，并且其特征在于从生物材料整个内部的外部延伸的相互连通的孔。 冷凝的磷酸钙可用于代替硬结缔组织，或通过提供在其上体外或体内生长软组织的支撑物或将软结缔组织锚定到骨上来再生软结缔组织。

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