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公开(公告)号：US20150376671A1
公开(公告)日：2015-12-31
申请号：US14754262
申请日：2015-06-29
IPC分类号： C12P19/34
CPC分类号： C12P19/34 , C07K14/4703 , C07K14/5406 , C12Q1/686 , C12Q2521/131 , C12Q2525/161 , C12Q2527/125 , C12Q2565/627
摘要： The present invention realtes to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3′ non-templated nucleotide addition.
摘要翻译： 本发明涉及用于扩增核酸的系统和方法。 特别地，提供了用于在多核苷酸扩增设置（例如，聚合酶链式反应）内抑制基于聚合酶的末端转移酶活性的系统和方法。 此外，提供了用于产生用具有减少的3'非模板核苷酸添加的多核苷酸扩增技术产生的扩增产物的系统和方法。
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公开(公告)号：US20160145676A1
公开(公告)日：2016-05-26
申请号：US14947771
申请日：2015-11-20
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson , Ronald K. Bergold , Robert D. Miller , Kevin S. Oberkramer
CPC分类号： C12Q1/686 , B01L7/52 , C12Q1/6806 , G01N27/72 , G01N35/00871 , G01N35/0092 , G01N35/0095 , G01N35/0098 , G01N35/025 , G01N35/026 , G01N2035/00534
摘要： The present invention provides systems and methods for analysis of samples, particularly biological and environmental sample to detect biomolecules of interest contained therein. A variety of system components are described herein, including, but not limited to, components for sample handling, mixing of materials, sample processing, transfer of materials, and analysis of materials. The invention further provides mechanisms for combining and integrating the different components and for housing, moving, and storing system components or the system as a whole. The systems may include any one or more or all of these components. The system finds particular use when employed for analysis of nucleic acid molecule using mass spectrometry, however, the invention is not limited such specific uses.
摘要翻译： 本发明提供用于分析样品，特别是生物和环境样品以检测其中所含感兴趣的生物分子的系统和方法。 本文描述了各种系统组件，包括但不限于用于样品处理，材料混合，样品处理，材料转移和材料分析的组件。 本发明还提供了用于组合和集成不同部件并且用于整体地容纳，移动和存储系统部件或系统的机构。 这些系统可以包括这些组件中的任何一个或多个或全部。 当使用质谱法分析核酸分子时，该系统特别有用，但本发明不限于此。
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公开(公告)号：US20160116379A1
公开(公告)日：2016-04-28
申请号：US14920652
申请日：2015-10-22
发明人： James C. Hannis , Sherilynn Manalili Wheeler , Thomas N. Chiesl , Jared J. Drader , Steven A. Hofstadler , Ronald K. Bergold , Paul J. Gleason , Zachary T. Hannis
CPC分类号： G01N1/02 , B01L3/5029 , B01L3/52 , B01L2200/141 , B01L2200/16 , B01L2300/047 , B01L2300/0672 , B01L2300/069 , B01L2300/0809 , B01L2300/0832 , B01L2400/0481 , B01L2400/0683 , G01N2001/028
摘要： Provided herein are apparatuses, systems, kits and methods for sterilely delivering fluid to an elongated swab. In particular, provided herein are apparatuses configured to sterilely deliver a desired fluid to a swab contained within a swab housing.
摘要翻译： 本文提供了用于将流体无菌递送到细长拭子的装置，系统，试剂盒和方法。 特别地，本文提供了被配置为将期望的流体无菌递送到包裹在拭子外壳内的拭子的装置。
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4.发明申请METHODS FOR RAPID DETECTION AND IDENTIFICATION OF BIOAGENTS IN EPIDEMIOLOGICAL AND FORENSIC INVESTIGATIONS 审中-公开流行病学和传染性调查中快速检测和鉴定生物活性的方法公开(公告)号：US20150225780A1
公开(公告)日：2015-08-13
申请号：US14058723
申请日：2013-10-21
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , James C. Hannis
IPC分类号： C12Q1/68
CPC分类号： C12Q1/689 , C12Q1/6813 , C12Q1/6858 , C12Q1/686 , C12Q1/6888 , C12Q2600/156 , Y02A50/59 , Y02A50/60 , Y02A90/24 , C12Q2565/627 , C12Q2545/113 , C12Q2563/167
摘要： The present invention provides methods for rapid forensic investigations by identification of bioagents associated with biowarfare and acts of terrorism or crime. The methods are also useful for epidemiological investigations by genotyping of bioagents.
摘要翻译： 本发明提供了通过识别与生物武器相关的生物标签和恐怖主义或犯罪行为进行快速法医调查的方法。 该方法也可用于通过基因分型生物学的流行病学调查。
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公开(公告)号：US09165740B2
公开(公告)日：2015-10-20
申请号：US14450884
申请日：2014-08-04
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
IPC分类号： H01J49/10 , H01J49/04 , H01J49/26 , F23D11/32 , H01J27/02 , G01R31/28 , H01J49/16 , C12Q1/68 , G01N23/00
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
摘要翻译： 本发明一般涉及样品离子化，并且提供电离探针组件，系统，计算机程序产品和用于此目的的方法。
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6.发明申请METHODS FOR RAPID FORENSIC ANALYSIS OF MITOCHONDRIAL DNA AND CHARACTERIZATION OF MITOCHONDRIAL DNA HETEROPLASMY 有权麻醉DNA快速鉴别分析方法及MITOCHONDRIAL DNA HETEROPLASMY的表征公开(公告)号：US20150031117A1
公开(公告)日：2015-01-29
申请号：US14456806
申请日：2014-08-11
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill K. White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
摘要翻译： 本发明提供线粒体DNA的快速法医分析方法和线粒体DNA异质性表征的方法，可用于评估线粒体疾病的进展。
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公开(公告)号：US20180164280A1
公开(公告)日：2018-06-14
申请号：US15804711
申请日：2017-11-06
发明人： David J. Ecker , Stanley T. Motley , James C. Hannis , Lara G. Krieg , Todd P. Michael , David D. Duncan , Shane G. Poplawski , Thomas N. Chiesl
IPC分类号： G01N33/487 , C12Q1/6806 , C12Q1/6869
CPC分类号： G01N33/48721 , B82Y5/00 , C12Q1/6806 , C12Q1/6869 , C12Q2525/113 , C12Q2525/117 , C12Q2525/119 , C12Q2525/191 , C12Q2535/00 , C12Q2521/531 , C12Q2563/116 , C12Q2565/631
摘要： Provided herein is technology relating to nanopore analysis of nucleic acids and particularly, but not exclusively, to compositions, methods, systems, and kits for analysis of nucleic acids or other assays comprising nucleic acid components.
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公开(公告)号：US20160104610A1
公开(公告)日：2016-04-14
申请号：US14886979
申请日：2015-10-19
发明人： Steven A. Hofstadler , Jose R. Gutierrez , James C. Hannis , Jared J. Drader , Rex O. Bare , Jeffrey C. Smith , Paul J. Gleason , Jared Nathanson
CPC分类号： H01J49/165 , C12Q1/6872 , G01N23/00 , G01R31/2812 , G01R31/2848 , G01R31/2853 , H01J27/02 , H01J49/0422 , H01J49/0431 , H01J49/0468
摘要： The invention relates generally to sample ionization, and provides ionization probe assemblies, systems, computer program products, and methods useful for this purpose.
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公开(公告)号：US09752184B2
公开(公告)日：2017-09-05
申请号：US14456806
申请日：2014-08-11
发明人： David J. Ecker , Richard H. Griffey , Rangarajan Sampath , Steven A. Hofstadler , John McNeil , Stanley T. Crooke , Lawrence B. Blyn , Thomas A. Hall , Yun Jiang , James C. Hannis , Neill K. White , Vivek Samant , Mark W. Eshoo , Jared J. Drader
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q1/6806 , C12Q1/6844 , C12Q1/6858 , C12Q1/6872 , C12Q1/6888 , C12Q1/689 , C12Q2600/156 , G01N2333/28 , G01N2333/32 , G01N2333/35 , G01N2333/36 , C12Q2563/167 , C12Q2545/101 , C12Q2531/113 , C12Q2565/627 , C12Q2545/113
摘要： The present invention provides methods for rapid forensic analysis of mitochondrial DNA and methods for characterizing heteroplasmy of mitochondrial DNA, which can be used to assess the progression of mitochondrial diseases.
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公开(公告)号：US09752173B2
公开(公告)日：2017-09-05
申请号：US14754262
申请日：2015-06-29
CPC分类号： C12P19/34 , C07K14/4703 , C07K14/5406 , C12Q1/686 , C12Q2521/131 , C12Q2525/161 , C12Q2527/125 , C12Q2565/627
摘要： The present invention realtes to systems and methods for amplifying nucleic acid. In particular, systems and methods are provided for inhibiting polymerase based terminal transferase activity within a polynucleotide amplification setting (e.g., polymerase chain reaction). In addition, systems and methods are provided for generating amplified products generated with polynucleotide amplification techniques having reduced 3′ non-templated nucleotide addition.
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