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公开(公告)号：US10577634B2
公开(公告)日：2020-03-03
申请号：US15462975
申请日：2017-03-20
发明人： Paul S. Pearlman , Changlin Chen , Adriana L. Botes , Alex Van Eck Conradie , Benjamin D. Herzog
IPC分类号： C12P7/44 , C12N9/02 , C12P13/04 , C12P17/10 , C08G69/16 , C08G69/14 , C08G69/26 , C08G69/28 , B29B9/16 , C12N9/04 , C12N9/10 , C12N9/16 , C12N9/88 , C12N9/00 , C12P7/40 , C12P7/62 , C12P13/00 , C12P7/42 , C12P13/02 , C12N9/24
摘要： Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
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公开(公告)号：US20160355844A1
公开(公告)日：2016-12-08
申请号：US15213830
申请日：2016-07-19
CPC分类号： C12P5/026 , C12N9/001 , C12N9/0071 , C12N9/88 , C12N15/52 , C12P5/02 , C12P7/16 , C12P7/18 , C12Y103/01035 , C12Y103/08 , C12Y114/11022 , C12Y401/01033 , C12Y402/01 , C12Y402/01127 , C12Y402/03027 , Y02E50/10 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
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公开(公告)号：US20150004660A1
公开(公告)日：2015-01-01
申请号：US14490270
申请日：2014-09-18
CPC分类号： C12P13/005 , C07K14/195 , C07K14/37 , C12N1/32 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/1029 , C12N9/1096 , C12N9/78 , C12N9/88 , C12N15/52 , C12P5/02 , C12P5/026 , C12P7/04 , C12P7/18 , C12P7/42 , C12P7/44 , C12P7/46 , C12P13/001 , C12P13/02 , C12P17/10 , C12Y101/01004 , C12Y101/01157 , C12Y202/01006 , C12Y203/01009 , C12Y401/01005
摘要： Embodiments of the invention relate to the enzymatic conversion of bioderived feedstocks to commercially valuable chemicals. The enzymatic conversions of the embodiments of the invention offer the potential for lower cost routes to these value-added chemicals. Some of the chemicals that are useful include nylon intermediates such as caprolactam, adipic acid, 1,6-hexamethylene diamine; butanediols such as 1,4-butanediol, 1,3-butanediol, and 2,3-butanediol; butanols such as 1-butanol, and 2-butanol; succinic acid, butadiene, isoprene, and 3-hydroxypropanoic acid.
摘要翻译： 本发明的实施方案涉及生物活性原料的酶转化为商业上有价值的化学品。 本发明实施方案的酶促转化提供了对这些增值化学品的较低成本路线的潜力。 一些有用的化学物质包括尼龙中间体如己内酰胺，己二酸，1,6-六亚甲基二胺; 丁二醇如1,4-丁二醇，1,3-丁二醇和2,3-丁二醇; 丁醇如1-丁醇和2-丁醇; 琥珀酸，丁二烯，异戊二烯和3-羟基丙酸。
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公开(公告)号：US20160355843A1
公开(公告)日：2016-12-08
申请号：US15211237
申请日：2016-07-15
IPC分类号： C12P5/02 , C08J5/00 , C07C11/167 , C08F136/06 , C12N15/52 , C12N9/88
CPC分类号： C12P5/026 , C07C11/167 , C08F136/06 , C08J5/00 , C08J2347/00 , C12N9/001 , C12N9/88 , C12N15/52 , C12P5/02 , C12Y103/08 , C12Y401/01033 , C12Y402/01 , C12Y402/03027 , Y02E50/343 , Y02P20/52
摘要： This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.
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公开(公告)号：US10689673B2
公开(公告)日：2020-06-23
申请号：US14367484
申请日：2012-12-21
发明人： Paul S. Pearlman , Changlin Chen , Adriana L. Botes , Alex Van Eck Conradie , Benjamin D. Herzog
IPC分类号： C12P7/44 , C12P13/04 , C12P17/10 , C08G69/16 , C08G69/14 , C08G69/26 , C08G69/28 , B29B9/16 , C12N9/04 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/88 , C12N9/00 , C12P7/40 , C12P7/62 , C12P13/00 , C12P7/42 , C12P13/02
摘要： Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
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公开(公告)号：US20190352682A1
公开(公告)日：2019-11-21
申请号：US16372083
申请日：2019-04-01
摘要： This disclosure relates to strategies for in vivo production of certain carbon-based products, for example, aminated aliphatic compounds having a carbon chain length of C5-C19.
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公开(公告)号：US20170298396A1
公开(公告)日：2017-10-19
申请号：US15462975
申请日：2017-03-20
发明人： Paul S. Pearlman , Changlin Chen , Adriana L. Botes , Alex Van Eck Conradie , Benjamin D. Herzog
摘要： Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.
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公开(公告)号：US20190316072A1
公开(公告)日：2019-10-17
申请号：US16372106
申请日：2019-04-01
摘要： Provided herein are systems and methods for recycling and supplementing off-gas from a gas fed reaction process. The systems and methods are particularly useful for bioprocesses that convert hydrogen gas into one or more biosynthetic products. By maintaining separate hydrogen and oxygen feed gas streams, and forming a recycle gas that introduces a target component of the supply gas to the bioreactor within a target concentration range, the yields, productivities, and safety profiles of the bioprocess can be enhanced.
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公开(公告)号：US20190300839A1
公开(公告)日：2019-10-03
申请号：US16372099
申请日：2019-04-01
IPC分类号： C12M1/34
摘要： The present disclosure provides methods for controlling oxygen concentration during aerobic biosynthesis, e.g., fermentation. The method may comprise feeding an oxygen-containing gas into a vessel including a fermentation feedstock and reacting the fermentation feedstock with the oxygen-containing gas to form a broth including a gaseous phase dispersed within the broth. The gaseous phase may comprise any unreacted oxygen from the oxygen-containing gas. The method further includes reducing the concentration of the unreacted oxygen in the dispersed gaseous phase to less than the limiting oxygen concentration (“LOC”) for flammability before separating the gaseous phase from the fermentation broth. The concentration of the unreacted oxygen in the gaseous phase is reduced by employing oxygen removal schemes or oxygen dilution schemes.
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公开(公告)号：US20190300838A1
公开(公告)日：2019-10-03
申请号：US16372092
申请日：2019-04-01
摘要： Disclosed are materials and methods for managing aerobic biosynthesis. The materials include a fermenter system comprising a fermenter, a microorganism provided to the fermenter, and at least two control loops. The methods are directed to measuring and controlling different oxygen concentrations within the fermenter.
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