公开(公告)号：US20200025670A1

公开(公告)日：2020-01-23

申请号：US16515849

申请日：2019-07-18

申请人： ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： G01N15/14 ,  C08L83/12 ,  G03F7/00

摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

公开(公告)号：US12013330B2

公开(公告)日：2024-06-18

申请号：US16515849

申请日：2019-07-18

申请人： ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： G03F7/00 ,  C08L63/00 ,  C08L83/12 ,  G01N15/1434

CPC分类号： G01N15/1436 ,  C08L63/00 ,  C08L83/12 ,  G03F7/0002

摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

公开(公告)号：US11884976B2

公开(公告)日：2024-01-30

申请号：US16515790

申请日：2019-07-18

申请人： ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： C12Q1/6874 ,  C08G77/442 ,  C09D153/00 ,  C12Q1/6876 ,  C09D163/00 ,  C08L63/00 ,  C08L33/04

CPC分类号： C12Q1/6874 ,  C08G77/442 ,  C08L33/04 ,  C08L63/00 ,  C09D153/00 ,  C09D163/00 ,  C12Q1/6876

摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

公开(公告)号：US20200024661A1

公开(公告)日：2020-01-23

申请号：US16515790

申请日：2019-07-18

申请人： ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： C12Q1/6874 ,  C08G77/442 ,  C08L63/00 ,  C12Q1/6876 ,  C09D163/00 ,  C09D153/00

摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

公开(公告)号：US20240337582A1

公开(公告)日：2024-10-10

申请号：US18744225

申请日：2024-06-14

申请人： ILLUMINA, INC. ,  ILLUMINA CAMBRIDGE LIMITED

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： G01N15/1434 ,  C08L63/00 ,  C08L83/12 ,  G03F7/00

CPC分类号： G01N15/1436 ,  C08L63/00 ,  C08L83/12 ,  G03F7/0002

摘要： An example of a resin composition includes an epoxy resin matrix, a free radical photoinitiator selected from the group consisting of 2-ethyl-9,10-dimethoxyanthracene, 2,2-dimethoxy-2-phenylacetophenone, 2-ethoxy-2-phenylacetophenone, and a phosphine oxide, and a photoacid generator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.

公开(公告)号：US20230250248A1

公开(公告)日：2023-08-10

申请号：US18190685

申请日：2023-03-27

申请人： Illumina, Inc.

发明人： Lorenzo Berti ,  Andrew A. Brown ,  Wayne N. George

IPC分类号： C08J7/12 ,  C12Q1/6876 ,  C08F8/00 ,  C12Q1/6874 ,  B01J19/00 ,  C09D133/26 ,  C12Q1/6837

CPC分类号： C08J7/12 ,  C12Q1/6876 ,  C08F8/00 ,  C12Q1/6874 ,  B01J19/0046 ,  C09D133/26 ,  C12Q1/6837 ,  C08J2335/00 ,  B01J2219/00529 ,  B01J2219/00533 ,  B01J2219/00619 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00722 ,  C08F220/603

摘要： Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.

公开(公告)号：US11667957B2

公开(公告)日：2023-06-06

申请号：US16661885

申请日：2019-10-23

申请人： Illumina, Inc.

发明人： Darren Segale ,  Fiona E. Black ,  Jeffrey Dennis Brodin ,  Jeffrey Fisher ,  Lorenzo Berti ,  Siew Hong Leong

IPC分类号： C12Q1/6816 ,  C12Q1/6837

CPC分类号： C12Q1/6816 ,  C12Q1/6816 ,  C12Q2533/101 ,  C12Q2563/149 ,  C12Q2563/179 ,  C12Q2535/122

摘要： Some embodiments provided herein include methods and compositions for the detection of target ligands on an array. In some embodiments, a capture probe specifically binds to a target ligand from a sample, the location of a bead comprising the capture probe in an array is determined, and the bead is decoded to identify the capture probe and the sample. In some embodiments, a barcode is indicative of a capture probe attached to a bead; and an index is indicative of a subpopulation of beads. In some embodiments, the barcode and the index are determined by sequencing.

公开(公告)号：US20210189082A1

公开(公告)日：2021-06-24

申请号：US17194019

申请日：2021-03-05

申请人： Illumina, Inc.

发明人： Lorenzo Berti ,  Andrew A. Brown ,  Wayne N. George

IPC分类号： C08J7/12 ,  C12Q1/6876 ,  C08F8/00 ,  C12Q1/6874 ,  B01J19/00 ,  C09D133/26 ,  C12Q1/6837

摘要： Some embodiments described herein relate to a substrate with a surface comprising a silane or a silane derivative covalently attached to optionally substituted cycloalkene or optionally substituted heterocycloalkene for direct conjugation with a functionalized molecule of interest, such as a polymer, a hydrogel, an amino acid, a nucleoside, a nucleotide, a peptide, a polynucleotide, or a protein. In some embodiments, the silane or silane derivative contains optionally substituted norbornene or norbornene derivatives. Method for preparing a functionalized surface and the use in DNA sequencing and other diagnostic applications are also disclosed.

公开(公告)号：US20210108258A1

公开(公告)日：2021-04-15

申请号：US17113180

申请日：2020-12-07

申请人： ILLUMINA, INC.

发明人： M. Shane Bowen ,  Kevin L. Gunderson ,  Shengrong Lin ,  Maria Candelaria Rogert Bacigalupo ,  Kandaswamy Vijayan ,  Yir-Shyuan Wu ,  Bala Murali Venkatesan ,  James Tsay ,  John M. Beierle ,  Lorenzo Berti ,  Sang Ryul Park

IPC分类号： C12Q1/6844 ,  C40B50/18 ,  C12Q1/686 ,  B01J19/00

摘要： A method includes forming a patterned substrate including a plurality of base pads, using a nano-imprint lithography process. A capture substance is attached to each of the plurality of base pads, optionally through a linker, the capture substance being adapted to promote capture of a target molecule.

公开(公告)号：US20240132954A1

公开(公告)日：2024-04-25

申请号：US18400702

申请日：2023-12-29

申请人： ILLUMINA, INC.

发明人： Timothy J. Merkel ,  Wayne N. George ,  Andrew A. Brown ,  Audrey Zak ,  Gianluca Andrea Artioli ,  Julia Morrison ,  Nikolai Romanov ,  Lorenzo Berti ,  Graham Boud

IPC分类号： C12Q1/6874 ,  C08G77/442 ,  C08L33/04 ,  C08L63/00 ,  C09D153/00 ,  C09D163/00 ,  C12Q1/6876

CPC分类号： C12Q1/6874 ,  C08G77/442 ,  C08L33/04 ,  C08L63/00 ,  C09D153/00 ,  C09D163/00 ,  C12Q1/6876

摘要： An example of a resin composition includes a free radical curable resin matrix including an acrylate and a siloxane, and a free radical photoinitiator. When cured, the resin composition has low or no autofluorescence when exposed to blue excitation wavelengths ranging from about 380 nm to about 480 nm or green excitation wavelengths ranging from about 510 nm to about 560 nm.