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    Anti-tumor agent comprising salmosin as an active ingredient
    8.
    发明授权
    Anti-tumor agent comprising salmosin as an active ingredient 有权
    抗肿瘤剂包括沙莫沙星作为活性成分

    公开(公告)号：US06537551B2

    公开(公告)日：2003-03-25

    申请号：US09776268

    申请日：2001-02-02

    申请人： Doo-Sik Kim ,  Kwang Hoe Chung ,  In-Cheol Kang

    发明人： Doo-Sik Kim ,  Kwang Hoe Chung ,  In-Cheol Kang

    IPC分类号： A61K3900

    CPC分类号： C07K14/46 ,  A61K38/00 ,  A61K48/00

    摘要： The present invention relates to an anti-tumor agent comprising Salmosin which is a novel disintegrin containing Arg-Gly-Asp (RGD) sequence and derived from venom of Korean snake, Agkistrodon halys brevicaudus, as an active ingredient. Salmosin is a disintegrin which blocks the function of &agr;v&bgr;3 integrin and strongly inhibits tumor angiogenesis, tumor metastasis as well as growth of solid tumor. Salmosin does not exhibit cytotoxicity within an effective dose range where tumor growth is efficiently suppressed without any untoward effect on preexisting blood vessels and normal angiogenesis. Accordingly, Salmosin can be applied for the development of potent anti-tumor drugs which are effective for various types of cancers.

    摘要翻译： 本发明涉及含有Salmosin的抗肿瘤剂，其为含有Arg-Gly-Asp（RGD）序列的新型去整合素，其衍生自作为活性成分的韩国蛇（Agkistrodon halys brevicaudus）的毒液。 Salmosin是一种阻断alphavbeta3整合素功能的解体蛋白，强烈抑制肿瘤血管生成，肿瘤转移以及实体瘤的生长。 Salmosin在有效剂量范围内不显示细胞毒性，其中肿瘤生长被有效抑制，而对预先存在的血管和正常血管生成没有任何不利影响。 因此，Salmosin可用于开发对各种类型的癌症有效的有效的抗肿瘤药物。

    Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody
    9.
    发明授权
    Monoclonal antibody against D-dimer and diagnosis agent for detecting D-dimer, crosslinked fibrin and its derivatives containing D-dimer by using the antibody 有权
    用于D-二聚体的单克隆抗体和通过使用抗体检测D-二聚体，交联的纤维蛋白及其含有D-二聚体的衍生物的诊断剂

    公开(公告)号：US08940489B2

    公开(公告)日：2015-01-27

    申请号：US12428321

    申请日：2009-04-22

    申请人： Hyun-Ju Doh ,  Doo-Sik Kim ,  Kwang-Hoe Chung

    发明人： Hyun-Ju Doh ,  Doo-Sik Kim ,  Kwang-Hoe Chung

    IPC分类号： G01N33/53 ,  C12Q1/00 ,  A61K39/395 ,  C07K16/18 ,  G01N33/86

    CPC分类号： G01N33/86 ,  C07K16/18 ,  C07K16/36 ,  C07K2317/92 ,  G01N2333/75 ,  G01N2800/224

    摘要： Disclosed are a monoclonal antibody against human D-dimer produced in a mouse and high molecular weight cross-linked fibrin including a corresponding epitope, a cell line secreting the monoclonal antibody, and methods for producing the same. The anti-D-dimer monoclonal antibody of the present invention may be effectively used as a diagnotic agent for screening and detecting in-vivo D-dimer, and high molecular weight cross-linked fibrin and its derivatives containing the D-dimer since the monoclonal antibody specifically reacts with D-dimer, and cross-linked fibrin and its derivatives containing the D-dimer, which do not bind to human fibrinogen or fibrin.

    摘要翻译： 公开了在小鼠中产生的人D-二聚体的单克隆抗体和包含相应表位的高分子量交联纤维蛋白，分泌单克隆抗体的细胞系及其制备方法。 本发明的抗-D二聚体单克隆抗体可以有效地用作筛选和检测体内D-二聚体和高分子量交联的纤维蛋白及其含有D-二聚体的衍生物的诊断剂，因为单克隆抗体 抗体与D-二聚体特异性反应，以及交联的纤维蛋白及其含有D-二聚体的衍生物，其不结合人纤维蛋白原或纤维蛋白。

    Monoclonal Antibody Against D-Dimer and Diagnosis Agent for Detecting D-Dimer, Crosslinked Fibrin and its Derivatives Containing D-Dimer by Using the Antibody
    10.
    发明申请
    Monoclonal Antibody Against D-Dimer and Diagnosis Agent for Detecting D-Dimer, Crosslinked Fibrin and its Derivatives Containing D-Dimer by Using the Antibody 有权
    用于通过使用抗体检测D-二聚体，交联的纤维蛋白及其衍生物的D-二聚体和诊断剂的单克隆抗体

    公开(公告)号：US20090298100A1

    公开(公告)日：2009-12-03

    申请号：US12428321

    申请日：2009-04-22

    申请人： Hyun-Ju Doh ,  Doo-Sik Kim ,  Kwang-Hoe Chung

    发明人： Hyun-Ju Doh ,  Doo-Sik Kim ,  Kwang-Hoe Chung

    IPC分类号： G01N33/53 ,  C07K16/18

    CPC分类号： G01N33/86 ,  C07K16/18 ,  C07K16/36 ,  C07K2317/92 ,  G01N2333/75 ,  G01N2800/224

    摘要： Disclosed are a monoclonal antibody against human D-dimer produced in a mouse and high molecular weight crosslinked fibrin including a corresponding epitope, a cell line secreting the monoclonal antibody, and a method for manufacturing the same. The anti-D-dimer monoclonal antibody of the present invention may be effectively used as a diagnosis agent for screening and detecting in vivo D-dimer, and high molecular weight crosslinked fibrin and its derivatives containing the D-dimer since the monoclonal antibody specifically reacts with D-dimer, and crosslinked fibrin and its derivatives containing the D-dimer, which do not bind to human fibrinogen or fibrin.

    摘要翻译： 公开了在小鼠中产生的抗人D-二聚体的单克隆抗体和包含相应表位的分子量高的交联纤维蛋白，分泌单克隆抗体的细胞系及其制备方法。 本发明的抗-D二聚体单克隆抗体可以有效地用作筛选和检测体内D-二聚体，含有D-二聚体的高分子量交联纤维蛋白及其衍生物的诊断剂，因为单克隆抗体特异性地反应 与D-二聚体，和交联的纤维蛋白及其衍生物含有D-二聚体，其不结合人纤维蛋白原或纤维蛋白。