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    Methods and compositions for detecting polynucleotides
    1.
    发明申请
    Methods and compositions for detecting polynucleotides 有权
    用于检测多核苷酸的方法和组合物

    公开(公告)号：US20070231821A1

    公开(公告)日：2007-10-04

    申请号：US11710667

    申请日：2007-02-23

    申请人： Charles Bupp ,  K. Choi ,  Rachel Holmes-Davis ,  Alexander Izmailov ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Brian Warner ,  Michael Zwick

    发明人： Charles Bupp ,  K. Choi ,  Rachel Holmes-Davis ,  Alexander Izmailov ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Brian Warner ,  Michael Zwick

    IPC分类号： C12Q1/68 ,  C07D417/02 ,  C07D413/02 ,  C07D401/02

    CPC分类号： C12Q1/6876 ,  C12Q1/6813 ,  C12Q2600/156

    摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a polynucleotide that may include nucleic acid analogs and that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/polynucleotide hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/polynucleotide hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

    摘要翻译： 提供了确定样品中靶多核苷酸的存在或量的方法。 含有靶多核苷酸，可包括核酸类似物并与靶多核苷酸的靶核酸序列互补的多核苷酸的样品和在存在和/或存在的情况下光学性质的变化率不同的染料 组合不存在靶多核苷酸/多核苷酸杂交体以产生反应混合物。 将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/多核苷酸杂化物的类似反应混合物中的染料的光学性质变化率的变化率的参考值进行比较 确定光学性质的相对变化率。 反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。

    System for detecting polynucleotides
    2.
    发明申请
    System for detecting polynucleotides 有权
    多核苷酸检测系统

    公开(公告)号：US20060147958A1

    公开(公告)日：2006-07-06

    申请号：US11285025

    申请日：2005-11-21

    申请人： Heather Koshinsky ,  Michael Zwick ,  K. Choi

    发明人： Heather Koshinsky ,  Michael Zwick ,  K. Choi

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6816 ,  Y02A50/52 ,  Y10T436/143333 ,  C12Q2565/107 ,  C12Q2525/113 ,  C12Q2525/107 ,  C12Q2545/113 ,  C12Q2527/125

    摘要： The present invention relates to methods for detecting the presence or amount of a target polynucleotide. A polynucleotide, target nucleic acid analog, and dye are combined to form a mixture. The optical property of the dye is observed after the mixture is exposed to a stimulating means. Optionally, after the stimulating means is employed, the mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar mixture containing a known amount of a target polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The change in a property of the mixture after exposure thereof to a stimulating means or the relative rate of change in the optical property of dye in the mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

    摘要翻译： 本发明涉及用于检测靶多核苷酸的存在或量的方法。 将多核苷酸，靶核酸类似物和染料合并形成混合物。 在将混合物暴露于刺激装置之后，观察染料的光学性质。 任选地，在使用刺激装置之后，将混合物与包含已知量的靶多核苷酸/核酸模拟杂交体的类似混合物中的染料的光学性能的变化率的特性参考值进行比较，以确定 相对光学性质的变化率。 将混合物暴露于刺激装置后的混合物的性质的变化或混合物中染料的光学性质的相对变化率与样品中指定的靶多核苷酸的存在或量相关。

    Laboratory Spatula
    5.
    发明申请
    Laboratory Spatula 审中-公开
    实验室飞溅

    公开(公告)号：US20080011107A1

    公开(公告)日：2008-01-17

    申请号：US11597498

    申请日：2005-06-07

    申请人： Margret Leventhal ,  Heather Koshinsky ,  Michael Zwick ,  Charles Bupp II

    发明人： Margret Leventhal ,  Heather Koshinsky ,  Michael Zwick ,  Charles Bupp II

    IPC分类号： G01N1/10 ,  B01L3/18

    CPC分类号： B01L3/18

    摘要： Laboratory spatula having stalk regions with a hollow first end and a hollow second end and at manipulating regions may be used for collecting, transporting or storing a material. A manipulating region may be configured as a shovel region, a scoop region, a whisk region, a punch region, a sieve region, a loop region, a cutting edge, a spreading region, a grinding region, a hook region, a scraper region, a tweezer region, a grasper region, or a pick region. The spatula may be lightweight and disposable, and may be any appropriate size including micro size, a regular size, or a macro size. The spatula may also have an anti-stick surface. The spatula may be calibrated, and may include calibration marks or additional features.

    摘要翻译： 具有中空第一端和中空第二端以及操纵区域的茎区的实验室铲具可用于收集，运输或储存材料。 操作区域可以被构造为铲区域，铲斗区域，搅拌区域，冲压区域，筛区域，环区域，切削刃，扩展区域，磨削区域，钩区域，刮刀区域 ，镊子区域，抓紧区域或拾取区域。 刮刀可以是轻质的和一次性的，并且可以是任何适当的尺寸，包括微尺寸，常规尺寸或宏尺寸。 刮刀还可以具有防粘表面。 刮刀可以被校准，并且可以包括校准标记或附加特征。

    Methods and compositions for detecting polynucleotides
    6.
    发明申请
    Methods and compositions for detecting polynucleotides 审中-公开
    用于检测多核苷酸的方法和组合物

    公开(公告)号：US20080096193A1

    公开(公告)日：2008-04-24

    申请号：US11362359

    申请日：2006-10-24

    申请人： Charles Robert Bupp ,  K. Yeon Choi ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Michael Zwick

    发明人： Charles Robert Bupp ,  K. Yeon Choi ,  Heather Koshinsky ,  Christopher Nulf ,  Mickey Urdea ,  Miaomiao Wang ,  Michael Zwick

    IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07D417/02

    CPC分类号： C12Q1/6816 ,  C12Q2565/107

    摘要： Methods of determining the presence or amount of a target polynucleotide in a sample are provided. A sample that contains a target polynucleotide, a nucleic acid analog that is complementary to a target nucleic acid sequence of the target polynucleotide, and a dye for which the rate of change in an optical property is different in the presence and absence of a target polynucleotide/nucleic acid analog hybrid are combined to produce a reaction mixture. The rate of change in an optical property of the dye in the reaction mixture is compared to a reference value characteristic of the rate of change in the optical property of the dye in a similar reaction mixture containing a known amount of a polynucleotide/nucleic acid analog hybrid to determine a relative rate of change in the optical property. The relative rate of change in the optical property of dye in the reaction mixture is correlated with the presence or amount of the specified target polynucleotide in the sample.

    摘要翻译： 提供了确定样品中靶多核苷酸的存在或量的方法。 含有目标多聚核苷酸，与靶多核苷酸的靶核酸序列互补的核酸类似物的样品和在存在和不存在靶​​多核苷酸时光学性质的变化率不同的染料 /核酸类似物混合物组合以产生反应混合物。 将反应混合物中染料的光学性质的变化率与含有已知量的多核苷酸/核酸类似物的类似反应混合物中的染料的光学性质变化率的参考值进行比较 混合以确定光学性质的相对变化率。 反应混合物中染料的光学性质的相对变化率与样品中特定靶多核苷酸的存在或数量相关。

    Lid for sample holder
    7.
    发明授权
    Lid for sample holder 有权
    盖样品架

    公开(公告)号：US06626051B2

    公开(公告)日：2003-09-30

    申请号：US09930099

    申请日：2001-08-14

    申请人： Michael Zwick ,  Heather Koshinsky

    发明人： Michael Zwick ,  Heather Koshinsky

    IPC分类号： B01L300

    CPC分类号： B01L3/50853 ,  B01L2200/021 ,  B01L2200/026 ,  B01L2200/0642 ,  B01L2300/04 ,  B01L2300/046 ,  B01L2300/0829 ,  B01L2300/0864 ,  G01N1/18 ,  Y10T436/25 ,  Y10T436/2575

    摘要： A lid for a sample holder that includes a load port, a first flow channel, and a second flow channel. The first flow channel includes a first end connected to the load port and a second end that opens into a first reservoir of the sample holder. The second flow channel also includes a first end connected to the load port and a second end that opens into a second reservoir of the sample holder.

    摘要翻译： 一种用于样本保持器的盖子，其包括负载端口，第一流动通道和第二流动通道。 第一流动通道包括连接到负载端口的第一端和通向样品保持器的第一储存器的第二端。 第二流动通道还包括连接到负载端口的第一端和通向样品保持器的第二储存器的第二端。

    Methods of preparing nucleic acid for detection
    8.
    发明申请
    Methods of preparing nucleic acid for detection 审中-公开
    核酸检测方法

    公开(公告)号：US20070042400A1

    公开(公告)日：2007-02-22

    申请号：US11429746

    申请日：2006-05-08

    申请人： K. Choi ,  Michael Zwick ,  Kent Mccue

    发明人： K. Choi ,  Michael Zwick ,  Kent Mccue

    IPC分类号： C12Q1/68 ,  C12N1/08

    CPC分类号： C12Q1/6806 ,  C12N15/10

    摘要： Methods of preparing nucleic acid from polysaccharide-containing samples for detection by providing one or more glycosidases to the sample to degrade polysaccharides are provided. The nucleic acids can further be extracted from the sample. The method is particularly useful for detecting nucleic acid in samples with high starch content.

    摘要翻译： 提供了通过向样品中提供一种或多种糖苷酶来降解多糖来从含多糖样品中制备核酸以进行检测的方法。 可以从样品中进一步提取核酸。 该方法特别可用于检测具有高淀粉含量的样品中的核酸。

    Shirt and suspenders combination wherein suspenders are hidden in use
    10.
    发明申请
    Shirt and suspenders combination wherein suspenders are hidden in use 审中-公开
    衬衫和吊带组合，其中吊带被隐藏在使用中

    公开(公告)号：US20060185056A1

    公开(公告)日：2006-08-24

    申请号：US11067397

    申请日：2005-02-23

    申请人： Michael Zwick

    发明人： Michael Zwick

    IPC分类号： A41B1/00

    CPC分类号： A41B1/08 ,  A41D13/0007 ,  A41F3/00

    摘要： A shirt, suspenders and pants combination includes common suspenders having two front distal ends, each with means for being attached to the waistline of the pants, and two back distal ends, each with means for being attached to the waistline of the pants. The shirt conceals a majority of the suspenders, and includes a neckline, a tail tucked into the pants, below the waistline, a front side with two front slits, and a backside with two back slits. The front and back slits are positioned below the neckline and are positioned above the waistline of the pants. The suspenders are positioned under the shirt, and the two front distal ends extend through the two front slits and are secured to the waistline through the means provided. The two back distal ends likewise extend through the two back slits and are secured to the waistline through the means provided.

    摘要翻译： 衬衫，吊带和裤子组合包括具有两个前部远端的公共吊带，每个具有附接到裤子的腰围的装置和两个后部远端，每个具有附接到裤子的腰围的装置。 这件衬衫隐藏了大多数的吊带，包括一条领口，一条尾巴卷入裤子，腰围下方，前侧有两个前缝，后侧有两个后缝。 前缝和后缝均位于领口下方，并位于裤子腰围之上。 吊架位于衬衫下方，两个前部远端延伸穿过两个前部狭缝，并通过所提供的装置固定在腰围上。 两个后部远端同样延伸穿过两个后缝隙，并通过所提供的装置固定在腰围上。