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公开(公告)号：US20190085367A1
公开(公告)日：2019-03-21
申请号：US16132746
申请日：2018-09-17
发明人： Takashi SHIBUYA , Seisuke IZAWA , Toshio MIYAKE
摘要： The present invention aims to provide a particulate composition containing pullulan, which can be produced without employing any complicated purification step such as solvent precipitation and, when formed into a film, exhibits a higher rupture strength compared to conventional ones; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing pullulan which is produced from a culture obtained by culturing a mutant of a microorganism of the species Aureobasidium pullulans in a culture medium containing glucose and maltose as carbon sources, without employing a step of removing concomitant saccharides; contains a pullulan fraction and a concomitant saccharide fraction that are respectively insoluble and soluble in 75% by volume of methanol in water; has a percentage of 3% by weight or lower of the content of concomitant saccharides contained in the concomitant saccharide fraction against the content of total saccharides contained in the whole particulate composition, when determined based on the anthrone sulfuric acid method; and contains mannitol; and by providing the process of the same and uses thereof.
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2.发明申请公开(公告)号：US20190077820A1
公开(公告)日：2019-03-14
申请号：US16196478
申请日：2018-11-20
发明人： Takashi SHIBUYA , Seisuke IZAWA
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
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公开(公告)号：US20190008747A1
公开(公告)日：2019-01-10
申请号：US16130207
申请日：2018-09-13
发明人： Takashi SHIBUYA , Akiko MIYAKE , Tatsuya ISHIHARA , Masaki MIYAKE , Hitomi WAKE
IPC分类号： A61K8/67 , A61Q19/08 , A61K8/49 , A61K8/34 , A61K8/64 , A61K8/98 , A61K8/92 , A61Q19/02 , A61K8/9789 , A61K8/9771 , A61K8/60 , A61Q19/00 , A61K31/7048 , A61K8/97
摘要： The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).
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4.发明申请PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权生产包含水溶性2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法公开(公告)号：US20160024131A1
公开(公告)日：2016-01-28
申请号：US14879280
申请日：2015-10-09
IPC分类号： C07H17/04
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
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5.发明申请公开(公告)号：US20180092936A1
公开(公告)日：2018-04-05
申请号：US15837273
申请日：2017-12-11
IPC分类号： A61K31/7048 , C12P19/18 , C07H17/04 , A61K9/16 , C12P19/60
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
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6.发明申请EXTERNAL DERMAL COMPOSITION FOR ANTI-AGEING AND METHOD FOR PRODUCING THE SAME 审中-公开用于抗老化的外用组合物及其制造方法公开(公告)号：US20150342854A1
公开(公告)日：2015-12-03
申请号：US14655068
申请日：2013-12-26
发明人： Takashi SHIBUYA , Akiko MIYAKE , Tatsuya ISHIHARA , Masaki MIYAKE , Hitomi WAKE
IPC分类号： A61K8/67 , A61Q19/02 , A61Q19/00 , A61K8/34 , A61K8/92 , A61K8/98 , A61K8/64 , A61K8/49 , A61Q19/08 , A61K8/97
CPC分类号： A61K8/676 , A61K8/345 , A61K8/4926 , A61K8/4953 , A61K8/498 , A61K8/602 , A61K8/64 , A61K8/922 , A61K8/97 , A61K8/9771 , A61K8/9789 , A61K8/988 , A61K31/7048 , A61K2800/5922 , A61K2800/805 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention has an object to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as wrinkles, fine wrinkles, blemishes, and saggings caused by increasing age or ageing; and maintains or improves the barrier function and the hyaluronic acid production in the skin. The object is solved by providing an external dermal composition for anti-ageing, which contains an aqueous medium as a base material and one or more ingredients selected from L-ascorbic acid, derivatives thereof, and their salts as an effective ingredient(s).
摘要翻译： 本发明的目的是提供一种防老化外皮组合物，其防止或改善由老化或老化引起的皱纹，细皱纹，瑕疵和皱纹等明显的皮肤问题; 并维持或改善皮肤中的屏障功能和透明质酸产生。 该目的通过提供一种抗老化的外用皮肤组合物来解决，该组合物含有作为基础材料的水性介质和选自L-抗坏血酸，其衍生物及其盐作为有效成分的一种或多种成分。
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7.发明申请PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING AN HYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权生产包含水溶性2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法公开(公告)号：US20140348922A1
公开(公告)日：2014-11-27
申请号：US14295546
申请日：2014-06-04
IPC分类号： A61K31/7048 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译： 本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。 制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得 将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过 控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。
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公开(公告)号：US20170360819A9
公开(公告)日：2017-12-21
申请号：US14879280
申请日：2015-10-09
IPC分类号： A61K31/7048 , C12P19/18 , A61K9/16 , C12P19/60 , C07H17/04
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
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9.发明申请公开(公告)号：US20180179245A1
公开(公告)日：2018-06-28
申请号：US15905407
申请日：2018-02-26
发明人： Takashi SHIBUYA , Seisuke IZAWA
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
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10.发明申请公开(公告)号：US20170320900A1
公开(公告)日：2017-11-09
申请号：US15653131
申请日：2017-07-18
发明人： Takashi SHIBUYA , Seisuke IZAWA
CPC分类号： C07H3/04 , C07H1/00 , C12N9/1074 , C12P19/12 , C12P19/14 , C12P19/18 , C12P19/20 , C12Y204/01019 , C13K13/007
摘要： A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus Arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus Arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals. Cyclomaltodextrin glucanotransferase derived from a microorganism of the genus Paenibacillus or a mutant enzyme thereof is used to increase the α,α-trehalose content in the saccharide solution to over 86.0% by weight, on a dry solid basis, without passing through a fractionation step by column chromatography.
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