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    PROGNOSTIC AND DIAGNOSTIC METHODS BASED ON QUANTIFICATION OF SOMATIC MICROSATELLITE VARIABILITY
    1.
    发明申请
    PROGNOSTIC AND DIAGNOSTIC METHODS BASED ON QUANTIFICATION OF SOMATIC MICROSATELLITE VARIABILITY 审中-公开
    基于定量微生物微生物变异性的预处理和诊断方法

    公开(公告)号：US20160040254A1

    公开(公告)日：2016-02-11

    申请号：US14815050

    申请日：2015-07-31

    Applicant: Harold Garner ,  Zalman Vaksman

    Inventor： Harold Garner ,  Zalman Vaksman

    IPC: C12Q1/68

    CPC classification number: C12Q1/6886 ,  C12Q1/6809 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G16B20/00 ,  C12Q2535/122 ,  C12Q2537/165

    Abstract: Prognostic and diagnostic methods based on somatic microsatellite variability measurements are described. Somatic microsatellite variability measurements can be used to identify defects in DNA repair pathways in a biological sample and to predict or identify one or more pathologies. The methods may statistically compare somatic microsatellite variability between a sample from a cell line or subject with that of a reference sample with defined pathological characteristics and/or defined lesions in DNA repair pathways. The methods are useful for determining the probability that an individual may develop a pathology, such as a cancer, within a specific time frame, and/or are useful as a diagnostic test. The methods have clinical utility in that somatic variability can be evaluated and/or measured as an indication of the amount of genomic instability (e.g., microsatellite and non-microsatellite/SNP), which can then be used as a clinical diagnostic to make clinical decisions, especially in the area of cancer.

    Abstract translation: 描述了基于体细胞微卫星变异性测量的预后和诊断方法。 体细胞微卫星变异性测量可用于鉴定生物样品中DNA修复途径中的缺陷并预测或鉴定一种或多种病理学。 这些方法可以统计学地比较来自细胞系或受试者的样品与具有确定的病理特征和/或DNA修复途径中限定的损伤的参考样品的体细胞微卫星变异性。 该方法对于确定个体在特定时间范围内可能发展病理学（例如癌症）和/或可用作诊断测试的可能性是有用的。 这些方法具有临床效用，因为可以评估和/或测量体细胞变异性作为基因组不稳定性的量的指示（例如，微卫星和非微卫星/ SNP），其然后可以用作临床诊断来进行临床决定 ，特别是在癌症领域。

    FOLDABLE VEHICLE PLAYSETS WITH MOVING COMPONENTS
    2.
    发明申请
    FOLDABLE VEHICLE PLAYSETS WITH MOVING COMPONENTS 失效
    具有移动组件的可折叠车辆游戏

    公开(公告)号：US20110130068A1

    公开(公告)日：2011-06-02

    申请号：US13007965

    申请日：2011-01-17

    Applicant: Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    Inventor： Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    IPC: A63H33/04

    CPC classification number: A63H18/026 ,  A63H18/023 ,  A63H18/028

    Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle may prevent the moving component from reaching the trigger. The playset may include at least two configurations including a closed configuration and an open configuration that is suitable for play.

    Abstract translation: 具有多种配置的车载电视 车辆队列可以包括轨道段，与轨道段相邻的触发器，适于朝向触发器移动的移动部件，以及耦合到轨道段的发射机构，并且适于沿着轨道段向移动状态发射玩具车辆 零件。 用玩具车敲击移动部件可以防止运动部件到达扳机。 播放组件可以包括至少两个配置，包括适合播放的封闭配置和打开配置。

    Pivotal jumping stick
    4.
    发明授权
    Pivotal jumping stick 失效
    枢轴跳棒

    公开(公告)号：US4390178A

    公开(公告)日：1983-06-28

    申请号：US381838

    申请日：1982-05-25

    Applicant: Elliot Rudell ,  Joseph Cernansky ,  Harold Garner

    Inventor： Elliot Rudell ,  Joseph Cernansky ,  Harold Garner

    IPC: A63B25/08

    CPC classification number: A63B25/08 ,  A63B2208/12

    Abstract: A pivotal jumping stick with the handlebars and footrest connected together and pivoted at their centers to permit the user to maintain his balance on uneven terrain. While in motion, a pin slides vertically in a slot formed in the impacting rod, counteracting the inherent twisting force of the spring mechanism, and allowing the user to accurately steer the device.

    Abstract translation: 一个关键的跳杆，把手和脚踏板连接在一起，并在其中心枢转，以允许用户在不平坦的地形上保持平衡。 在运动中，销在形成在冲击杆中的槽中垂直滑动，抵消弹簧机构的固有扭转力，并允许使用者精确地引导装置。

    Foldable vehicle playsets with moving components
    5.
    发明授权
    Foldable vehicle playsets with moving components 失效
    具有移动部件的可折叠车辆组合

    公开(公告)号：US08449344B2

    公开(公告)日：2013-05-28

    申请号：US13007965

    申请日：2011-01-17

    Applicant: Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    Inventor： Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    IPC: A63H33/04

    CPC classification number: A63H18/026 ,  A63H18/023 ,  A63H18/028

    Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle may prevent the moving component from reaching the trigger. The playset may include at least two configurations including a closed configuration and an open configuration that is suitable for play.

    Abstract translation: 具有多种配置的车载电视 车辆队列可以包括轨道段，与轨道段相邻的触发器，适于朝向触发器移动的移动部件，以及耦合到轨道段的发射机构，并且适于沿着轨道段向移动状态发射玩具车辆 零件。 用玩具车敲击移动部件可以防止运动部件到达扳机。 播放组件可以包括至少两个配置，包括适合播放的封闭配置和打开配置。

    Foldable vehicle playsets with moving components
    6.
    发明授权
    Foldable vehicle playsets with moving components 有权
    具有移动部件的可折叠车辆组合

    公开(公告)号：US07892068B2

    公开(公告)日：2011-02-22

    申请号：US11744771

    申请日：2007-05-04

    Applicant: Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    Inventor： Michael Nuttall ,  Harold Garner ,  Stacy O'Connor

    IPC: A63H18/06 ,  A63H29/00 ,  A63H3/52

    CPC classification number: A63H18/026 ,  A63H18/023 ,  A63H18/028

    Abstract: Vehicle playsets having multiple configurations. The vehicle playsets may include a track segment, a trigger adjacent to the track segment, a moving component adapted to move toward the trigger, and a launch mechanism coupled to the track segment and adapted to launch a toy vehicle along the track segment toward the moving component. Striking the moving component with the toy vehicle will prevent the moving component from reaching the trigger. The playset has at least two configurations including a closed configuration and an open configuration that is suitable for play.

    Abstract translation: 具有多种配置的车载电视 车辆队列可以包括轨道段，与轨道段相邻的触发器，适于朝向触发器移动的移动部件，以及耦合到轨道段的发射机构，并且适于沿着轨道段向移动状态发射玩具车辆 零件。 用玩具车敲击移动部件将会阻止移动部件到达扳机。 播放器具有至少两种配置，包括适合播放的封闭配置和开放配置。

    Toy vehicle raceways
    9.
    发明授权
    Toy vehicle raceways 有权
    玩具车滚道

    公开(公告)号：US07651398B2

    公开(公告)日：2010-01-26

    申请号：US11744781

    申请日：2007-05-04

    Applicant: Eric C. Ostendorff ,  Michael Nuttall ,  Harold Garner ,  Steve P. Dunham

    Inventor： Eric C. Ostendorff ,  Michael Nuttall ,  Harold Garner ,  Steve P. Dunham

    IPC: A63F9/14 ,  A63H18/00

    CPC classification number: A63H18/026 ,  A63H18/00

    Abstract: Toy raceways and finish line apparatuses for toy raceways are disclosed. Toy raceways may include a plurality of hingedly coupled multi-lane track segments, a starting apparatus, and a finish line apparatus. The plurality of hingedly coupled multi-lane track segments may be configured to foldably transition between a first configuration and a second configuration. In the first configuration, the plurality of hingedly coupled multi-lane track segments may be aligned to provide a multilane toy raceway, which may have a first end and a second end. In the second configuration, the plurality of hingedly coupled multi-lane track segments may produce a stack of folded track segments. The starting apparatus may be disposed proximate the first end of the toy raceway, and the finish line apparatus may be disposed proximate the second end of the toy raceway.

    Abstract translation: 公开了玩具滚道的玩具滚道和终点线装置。 玩具滚道可以包括多个铰链耦合的多车道轨道段，起动装置和终点线装置。 多个铰链耦合的多车道轨道段可以被配置为在第一配置和第二配置之间可折叠地转换。 在第一构造中，多个铰接的多车道轨道段可以对齐以提供可以具有第一端和第二端的多平面玩具滚道。 在第二配置中，多个铰链耦合的多车道轨道段可以产生折叠的轨道段的堆叠。 起动装置可以设置在玩具滚道的第一端附近，并且终点线装置可以设置在玩具滚道的第二端附近。

    DETECTING STRAIN IN BIREFRINGENT MATERIALS USING SPECTRAL POLARIMETRY
    10.
    发明申请
    DETECTING STRAIN IN BIREFRINGENT MATERIALS USING SPECTRAL POLARIMETRY 失效
    使用光谱极化法检测生物材料中的应变

    公开(公告)号：US20080094609A1

    公开(公告)日：2008-04-24

    申请号：US11848284

    申请日：2007-08-31

    Applicant: Anthony Ragucci ,  Alan Cisar ,  Michael Huebschman ,  Harold Garner

    Inventor： Anthony Ragucci ,  Alan Cisar ,  Michael Huebschman ,  Harold Garner

    IPC: G01B11/16

    CPC classification number: G01B11/168 ,  G01J3/2823 ,  G01J3/447

    Abstract: A method, computer program product and system for analyzing multispectral images from a plurality of regions of birefringent material, such as a polymer film, using polarized light and a corresponding polar analyzer to identify differential strain in the birefringent material. For example, the birefringement material may be low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene, polyethylene terephthalate (PET), polyvinyl chloride (PVC), polyvinylidene chloride, polyester, nylon, or cellophane film. Optionally, the method includes generating a real-time quantitative strain map.

    Abstract translation: 一种用于从双折射材料的多个区域（例如聚合物膜）使用偏振光和相应的极性分析仪分析多光谱图像以识别双折射材料中的微分应变的方法，计算机程序产品和系统。 例如，双折射材料可以是低密度聚乙烯（LDPE），高密度聚乙烯（HDPE），聚丙烯，聚对苯二甲酸乙二醇酯（PET），聚氯乙烯（PVC），聚偏二氯乙烯，聚酯，尼龙或玻璃纸膜。 可选地，该方法包括生成实时定量应变图。

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