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1.发明授权Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer 有权多通道荧光测量光学系统和多通道荧光样品分析仪公开(公告)号：US07928408B2
公开(公告)日：2011-04-19
申请号：US11345262
申请日：2006-02-01
Applicant: Gyeong-sik Ok , Su-hyeon Kim , Jin-tae Kim , Kwang-wook Oh
Inventor： Gyeong-sik Ok , Su-hyeon Kim , Jin-tae Kim , Kwang-wook Oh
IPC: G01N21/64
CPC classification number: G01J3/10 , G01J3/02 , G01J3/0218 , G01J3/0256 , G01J3/4406 , G01J2003/1213 , G01N21/05 , G01N21/6452 , G01N21/6456 , G01N2021/0346 , G01N2021/3174 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221 , G01N2201/0407 , G01N2201/0461 , G01N2201/0612 , G01N2201/0627 , G01N2201/0631 , G01N2201/0806 , G01N2201/0833
Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.
Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。
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2.发明申请Multi-channel fluorescence measuring optical system and multi-channel fluorescence sample analyzer 有权多通道荧光测量光学系统和多通道荧光样品分析仪公开(公告)号：US20060202133A1
公开(公告)日：2006-09-14
申请号：US11345262
申请日：2006-02-01
Applicant: Gyeong-sik Ok , Su-hyeon Kim , Jin-tae Kim , Kwang-wook Oh
Inventor： Gyeong-sik Ok , Su-hyeon Kim , Jin-tae Kim , Kwang-wook Oh
CPC classification number: G01J3/10 , G01J3/02 , G01J3/0218 , G01J3/0256 , G01J3/4406 , G01J2003/1213 , G01N21/05 , G01N21/6452 , G01N21/6456 , G01N2021/0346 , G01N2021/3174 , G01N2021/6419 , G01N2021/6421 , G01N2021/6471 , G01N2021/6484 , G01N2201/0221 , G01N2201/0407 , G01N2201/0461 , G01N2201/0612 , G01N2201/0627 , G01N2201/0631 , G01N2201/0806 , G01N2201/0833
Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples, includes: a light source; an integrator for giving the light irradiated from the light source a uniform intensity distribution; a sample holder having a plurality of sample channels on which the samples are mounted, wherein the samples are exited by the light emitted from the integrator; and a beam splitter between the integrator and the sample holder for dividing the incident light in a predetermined ratio. Since the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.
Abstract translation: 提供多通道荧光测量光学系统和使用该光学系统的多通道荧光样品分析仪。 多通道荧光测量光学系统，其将光照射到多个样品通道上并检测从样品辐射的荧光，包括：光源; 用于给从光源照射的光均匀的强度分布的积分器; 具有多个样品通道的样品架，样品安装在样品通道上，其中采样由积分器发出的光退出; 以及在积分器和样品保持器之间的分束器，用于以预定比例分割入射光。 由于使用光纤束和光电二极管检测荧光图像的光强度，因此可以大大降低制造成本，并且可以使光学系统小型化。
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3.发明申请Microchip unit, and method of conducting biochemical reaction using the microchip unit 审中-公开Microchip单元和使用微芯片单元进行生化反应的方法公开(公告)号：US20060078931A1
公开(公告)日：2006-04-13
申请号：US11245348
申请日：2005-10-06
Applicant: Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
Inventor： Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
CPC classification number: B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/065
Abstract: Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.
Abstract translation: 提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。 注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。 通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。 当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。
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4.发明授权Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same 有权用于分析多通道样品的光学系统和采用该多通道样品的多通道样品分析仪公开(公告)号：US07209237B2
公开(公告)日：2007-04-24
申请号：US11227385
申请日：2005-09-15
Applicant: Gyeong-sik Ok , Yoon-kyoung Cho , Jin-tae Kim , Kwang-wook Oh
Inventor： Gyeong-sik Ok , Yoon-kyoung Cho , Jin-tae Kim , Kwang-wook Oh
IPC: G01N21/25
CPC classification number: G01N21/645
Abstract: Provided are an optical system for analyzing multi-channel samples which uses a mirror rotating at high speeds and an aspherical mirror, and a multi-channel sample analyzer employing the optical system. The optical system for analyzing multi-channel samples, includes a light source unit which emits light traveling along an optical axis; a semi-spheroid aspherical mirror disposed in rotational symmetry about the optical axis; and an inclined mirror which reflects the light exiting the light source unit to the semi-spheroid aspherical mirror, while rotating about the optical axis, wherein an opening is formed in the center of the semi-spheroid aspherical mirror such that the light exiting the light source unit enters the inclined mirror through the semi-spheroid aspherical mirror.
Abstract translation: 提供了一种用于分析使用高速旋转的反射镜的多通道样品和非球面镜的光学系统，以及采用该光学系统的多通道样本分析仪。 用于分析多通道样品的光学系统包括发射沿着光轴行进的光的光源单元; 围绕光轴旋转对称设置的半球体非球面镜; 以及倾斜镜，其在围绕光轴旋转的同时将离开光源单元的光反射到半球形非球面镜，其中在半球镜非球面镜的中心形成开口，使得离开光的光 源单元通过半球体非球面镜进入倾斜镜。
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5.发明授权Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same 有权用于多通道多色测量的光学检测装置和采用其的多通道样本分析仪公开(公告)号：US07274455B2
公开(公告)日：2007-09-25
申请号：US11221055
申请日：2005-09-07
Applicant: Gyeong-sik Ok , Jin-tae Kim , Kwang-wook Oh , Sang-hyo Kim
Inventor： Gyeong-sik Ok , Jin-tae Kim , Kwang-wook Oh , Sang-hyo Kim
CPC classification number: G01N21/645 , G01J3/51 , G01N2021/6421 , G01N2021/6471
Abstract: Provided are an optical detection apparatus which can measure multi-channel samples at high speed and various wavelengths using an optical detector and a multi-channel sample analyzer employing the same. The optical detection apparatus includes an optical detector; a filter wheel having at least two color filters connected to each other in the shape of a disk; a plurality of optical channels through which a plurality of beams of light enter the filter wheel; and a mirror unit including a plurality of mirrors for sequentially reflecting the plurality of beams of light transmitted through the filter wheel to the optical detector, wherein the mirror unit rotates together with the filter wheel.
Abstract translation: 提供了一种光学检测装置，其可以使用光学检测器和使用该多通道样本的多通道样本分析仪来测量高速和各种波长的多通道样本。 光检测装置包括光检测器; 具有至少两个滤色器轮的滤光轮，所述至少两个滤色器以盘的形状彼此连接; 多个光通道，多个光束通过该光通道进入滤光轮; 以及反射镜单元，其包括多个反射镜，用于将透过滤光轮的多个光束顺序地反射到光学检测器，其中反射镜单元与滤光轮一起旋转。
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Patent Agency Ranking
6.发明申请Optical system for analyzing multi-channel samples and multi-channel sample analyzer employing the same 有权用于分析多通道样品的光学系统和采用该多通道样品的多通道样品分析仪公开(公告)号：US20060066857A1
公开(公告)日：2006-03-30
申请号：US11227385
申请日：2005-09-15
Applicant: Gyeong-sik Ok , Yoon-Kyoung Cho , Jin-tae Kim , Kwang-wook Oh
Inventor： Gyeong-sik Ok , Yoon-Kyoung Cho , Jin-tae Kim , Kwang-wook Oh
CPC classification number: G01N21/645
Abstract: Provided are an optical system for analyzing multi-channel samples which uses a mirror rotating at high speeds and an aspherical mirror, and a multi-channel sample analyzer employing the optical system. The optical system for analyzing multi-channel samples, includes a light source unit which emits light traveling along an optical axis; a semi-spheroid aspherical mirror disposed in rotational symmetry about the optical axis; and an inclined mirror which reflects the light exiting the light source unit to the semi-spheroid aspherical mirror, while rotating about the optical axis, wherein an opening is formed in the center of the semi-spheroid aspherical mirror such that the light exiting the light source unit enters the inclined mirror through the semi-spheroid aspherical mirror.
Abstract translation: 提供了一种用于分析使用高速旋转的反射镜的多通道样品和非球面镜的光学系统，以及采用该光学系统的多通道样本分析仪。 用于分析多通道样品的光学系统包括发射沿着光轴行进的光的光源单元; 围绕光轴旋转对称设置的半球体非球面镜; 以及倾斜镜，其在围绕光轴旋转的同时将离开光源单元的光反射到半球形非球面镜，其中在半球镜非球面镜的中心形成开口，使得离开光的光 源单元通过半球体非球面镜进入倾斜镜。
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7.发明申请Optical detection apparatus for multi-channel multi-color measurement and multi-channel sample analyzer employing the same 有权用于多通道多色测量的光学检测装置和采用其的多通道样本分析仪公开(公告)号：US20060050277A1
公开(公告)日：2006-03-09
申请号：US11221055
申请日：2005-09-07
Applicant: Gyeong-sik Ok , Jin-tae Kim , Kwang-wook Oh , Sang-hyo Kim
Inventor： Gyeong-sik Ok , Jin-tae Kim , Kwang-wook Oh , Sang-hyo Kim
IPC: G01N21/64
CPC classification number: G01N21/645 , G01J3/51 , G01N2021/6421 , G01N2021/6471
Abstract: Provided are an optical detection apparatus which can measure multi-channel samples at high speed and various wavelengths using an optical detector and a multi-channel sample analyzer employing the same. The optical detection apparatus includes an optical detector; a filter wheel having at least two color filters connected to each other in the shape of a disk; a plurality of optical channels through which a plurality of beams of light enter the filter wheel; and a mirror unit including a plurality of mirrors for sequentially reflecting the plurality of beams of light transmitted through the filter wheel to the optical detector, wherein the mirror unit rotates together with the filter wheel.
Abstract translation: 提供了一种光学检测装置，其可以使用光学检测器和使用该多通道样本的多通道样本分析仪来测量高速和各种波长的多通道样本。 光检测装置包括光检测器; 具有至少两个滤色器轮的滤光轮，所述至少两个滤色器以盘的形状彼此连接; 多个光通道，多个光束通过该光通道进入滤光轮; 以及镜单元，其包括多个反射镜，用于将透过滤光轮的多个光束顺序地反射到光学检测器，其中反射镜单元与滤光轮一起旋转。
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公开(公告)号：US20060187459A1
公开(公告)日：2006-08-24
申请号：US11330567
申请日：2006-01-11
Applicant: Gyeong-sik Ok , Jang-seok Ma
Inventor： Gyeong-sik Ok , Jang-seok Ma
IPC: G01N21/55
CPC classification number: B01L3/502715 , B01L3/5025 , B01L2300/0636 , B01L2300/0654 , B01L2300/0803 , B01L2300/0864 , B01L2300/168 , B01L2400/0409 , G01N21/07 , G01N21/553 , G01N2201/0637 , G01N2201/101 , G01N2201/104 , G02B5/04 , G02B7/1805 , G02B26/0833
Abstract: A portable biochip scanner includes a surface plasmon resonance unit formed in a rotational disk-shape and an optical head projecting light to the surface plasmon resonance unit at an angle within a predetermined range and detecting light totally-reflected from the surface plasmon resonance unit. The optical head is movable in a radial direction of the surface plasmon resonance unit.
Abstract translation: 便携式生物芯片扫描器包括以旋转盘形形成的表面等离子体共振单元和以预定范围内的角度投射到表面等离子体共振单元的光的光头，并且检测从表面等离子体共振单元全反射的光。 光头可以在表面等离子体共振单元的径向方向上移动。
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9.发明申请Long-range surface plasmon resonance device utilizing nano-scale porous dielectric and method of fabricating the same 失效利用纳米级多孔电介质的远程表面等离子体共振装置及其制造方法公开(公告)号：US20060170927A1
公开(公告)日：2006-08-03
申请号：US11205995
申请日：2005-08-17
Applicant: Fu Wang , Jang-seok Ma , Gyeong-sik Ok
Inventor： Fu Wang , Jang-seok Ma , Gyeong-sik Ok
IPC: G01N21/55
CPC classification number: G01N21/553
Abstract: A surface plasmon resonance device includes a transparent substrate, a porous dielectric layer formed on a top surface of the transparent substrate, a thin metal layer formed on the porous dielectric layer, and a prism attached on a bottom surface of the transparent layer.
Abstract translation: 表面等离子体共振装置包括透明基板，形成在透明基板的顶表面上的多孔电介质层，形成在多孔介电层上的薄金属层和安装在透明层的底表面上的棱镜。
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10.发明授权Long-range surface plasmon resonance device utilizing nano-scale porous dielectric and method of fabricating the same 失效利用纳米级多孔电介质的远程表面等离子体共振装置及其制造方法公开(公告)号：US07286235B2
公开(公告)日：2007-10-23
申请号：US11205995
申请日：2005-08-17
Applicant: Fu Wang , Jang-seok Ma , Gyeong-sik Ok
Inventor： Fu Wang , Jang-seok Ma , Gyeong-sik Ok
IPC: G01N21/55
CPC classification number: G01N21/553
Abstract: A surface plasmon resonance device includes a transparent substrate, a porous dielectric layer formed on a top surface of the transparent substrate, a thin metal layer formed on the porous dielectric layer, and a prism attached on a bottom surface of the transparent layer.
Abstract translation: 表面等离子体共振装置包括透明基板，形成在透明基板的顶表面上的多孔电介质层，形成在多孔介电层上的薄金属层和安装在透明层的底表面上的棱镜。
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