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公开(公告)号：US20230226074A1
公开(公告)日：2023-07-20
申请号：US17997273
申请日：2021-04-28
Applicant: Global Blood Therapeutics, Inc.
Inventor： Qing Xu , Carsten Alt , Zhe Li , Shahul Nillar , Peter Michael Rademacher , Calvin Wesley Yee
IPC: A61K31/5513 , A61K31/553 , A61K31/517 , A61K31/4709 , A61K31/519
CPC classification number: A61K31/5513 , A61K31/553 , A61K31/517 , A61K31/4709 , A61K31/519
Abstract: The subject matter described herein is directed to ferroportin inhibitor compounds of Formula (I) and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
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公开(公告)号：US20220402940A1
公开(公告)日：2022-12-22
申请号：US17887062
申请日：2022-08-12
Applicant: Global Blood Therapeutics, Inc.
Inventor： Zhe Li , Qing Xu , Brian W. Metcalf , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC: C07D498/08 , C07D213/74 , C07D401/04 , C07D403/04 , C07D491/107
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20210261520A1
公开(公告)日：2021-08-26
申请号：US17026690
申请日：2020-09-21
Applicant: Global Blood Therapeutics, Inc.
Inventor： Brian W. Metcalf , Zhe Li , Qing Xu , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC: C07D401/04 , A61K31/445 , C07D471/04 , C07D211/70 , C07D213/30 , C07D231/56 , C07D405/04 , C07F7/08 , C07D213/64 , C07D401/14 , C07D401/12 , A61K8/49 , C07D211/62 , C07D213/69 , C07D405/14 , C07C65/30 , C07D487/04 , C07D227/08 , C07D257/04 , A61K31/5375
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US10858317B2
公开(公告)日：2020-12-08
申请号：US16383049
申请日：2019-04-12
Applicant: Global Blood Therapeutics, Inc.
IPC: C07D207/08 , C07C271/16 , C07D207/34 , C07D211/22 , C07D211/60 , C07D211/78 , C07D213/81 , C07D241/04 , C07D265/30 , C07D279/12 , C07D309/08 , C07D309/28 , C07D333/38 , C07D335/02 , C07D401/06 , C07D211/16 , C07D401/12 , C07D207/48 , C07D403/06
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20180201577A1
公开(公告)日：2018-07-19
申请号：US15688185
申请日：2017-08-28
Applicant: Global Blood Therapeutics, Inc.
IPC: C07D207/08 , C07D403/06 , C07C271/16 , C07D401/06 , C07D335/02 , C07D333/38 , C07D309/28 , C07D309/08 , C07D279/12 , C07D265/30 , C07D241/04 , C07D213/81 , C07D211/78 , C07D211/60 , C07D211/22 , C07D211/16 , C07D207/48 , C07D207/34 , C07D401/12
CPC classification number: C07D207/08 , C07C271/16 , C07D207/34 , C07D207/48 , C07D211/16 , C07D211/22 , C07D211/60 , C07D211/78 , C07D213/81 , C07D241/04 , C07D265/30 , C07D279/12 , C07D309/08 , C07D309/28 , C07D333/38 , C07D335/02 , C07D401/06 , C07D401/12 , C07D403/06
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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Patent Agency Ranking
公开(公告)号：US09981939B2
公开(公告)日：2018-05-29
申请号：US14776603
申请日：2014-03-10
Applicant: Global Blood Therapeutics, Inc.
Inventor： Brian W. Metcalf , Zhe Li , Qing Xu , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC: C07D401/04 , C07D471/04 , C07D213/30 , C07D227/08 , C07D257/04 , C07D401/12 , A61K31/5375 , A61K31/445 , A61K8/49 , C07D211/70 , C07D213/69 , C07D401/14 , C07D405/04 , C07D405/14
CPC classification number: C07D401/04 , A61K8/4913 , A61K31/445 , A61K31/5375 , C07D211/70 , C07D213/30 , C07D213/69 , C07D227/08 , C07D257/04 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/14 , C07D471/04
Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US09815853B2
公开(公告)日：2017-11-14
申请号：US15177641
申请日：2016-06-09
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Zhe Li , Manuel Zancanella , Chul Yu , Lina Setti , Hing Sham , Qing Xu , Calvin Yee , Ming Yu
IPC: C07D519/00 , C07D405/12 , C07D307/81 , C07D491/18 , C07D401/12 , C07D493/08 , C07D213/73 , C07B59/00 , C07D487/08 , C07D471/08
CPC classification number: C07D519/00 , C07B59/002 , C07B2200/05 , C07D213/73 , C07D307/81 , C07D401/12 , C07D405/12 , C07D471/08 , C07D487/08 , C07D491/18 , C07D493/08
Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US09695166B2
公开(公告)日：2017-07-04
申请号：US14703848
申请日：2015-05-04
Applicant: Global Blood Therapeutics, Inc.
Inventor： Zhe Li , Qing Xu , Chul Yu , Calvin Yee , Stephen L. Gwaltney, II , Brian W. Metcalf , Steven Richards , Matthew A. Lardy , Lina Setti , Hing Sham
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61K31/437 , A61K31/4162
CPC classification number: C07D471/04 , C07D487/04 , C07D519/00
Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
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公开(公告)号：US11661410B2
公开(公告)日：2023-05-30
申请号：US16639051
申请日：2018-08-13
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Zhe Li , Ming Yu , Qing Xu , Manuel Zancanella
IPC: C07D403/12 , C07D401/14 , C07D405/14 , C07D219/10 , C07D221/06 , C07D401/12 , C07D413/12 , C07D471/04 , C07D471/08 , C07D491/044 , C07D491/056 , A61K31/473 , A61K31/4741 , A61K31/4375 , A61P35/00 , C07D215/42 , C07B59/00 , C07D487/04 , C07D453/02 , C07D487/08
CPC classification number: C07D401/12 , C07B59/002 , C07D215/42 , C07D401/14 , C07D405/14 , C07D413/12 , C07D453/02 , C07D487/04 , C07D487/08 , C07D491/044 , C07D491/056 , C07B2200/05
Abstract: The present disclosure provides certain tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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公开(公告)号：US20220396562A1
公开(公告)日：2022-12-15
申请号：US17242731
申请日：2021-04-28
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Qing Xu , CARSTEN ALT , ZHE LI , SHAHUL NILAR , PETER MICHAEL RADEMACHER , CALVIN WESLEY YEE
IPC: C07D401/14 , C07D471/08 , C07D401/04 , C07D403/04 , C07D413/14 , C07D405/14 , C07D417/14 , C07D498/08 , C07D417/04 , C07D471/04 , C07D491/056 , C07D413/04 , C07D403/14
Abstract: The subject matter described herein is directed to ferroportin inhibitor compounds of Formula I or I′ and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds, and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis, and also kidney injuries.
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