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公开(公告)号：US20210371417A1
公开(公告)日：2021-12-02
申请号：US17396312
申请日：2021-08-06
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Chul Yu , Ming Yu , Manuel Zancanella , Zhe Li
IPC: C07D471/04 , A61P7/00 , C07D519/00 , C07D487/04
Abstract: The present disclosure provides certain angular tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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公开(公告)号：US09815853B2
公开(公告)日：2017-11-14
申请号：US15177641
申请日：2016-06-09
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Zhe Li , Manuel Zancanella , Chul Yu , Lina Setti , Hing Sham , Qing Xu , Calvin Yee , Ming Yu
IPC: C07D519/00 , C07D405/12 , C07D307/81 , C07D491/18 , C07D401/12 , C07D493/08 , C07D213/73 , C07B59/00 , C07D487/08 , C07D471/08
CPC classification number: C07D519/00 , C07B59/002 , C07B2200/05 , C07D213/73 , C07D307/81 , C07D401/12 , C07D405/12 , C07D471/08 , C07D487/08 , C07D491/18 , C07D493/08
Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US09695166B2
公开(公告)日：2017-07-04
申请号：US14703848
申请日：2015-05-04
Applicant: Global Blood Therapeutics, Inc.
Inventor： Zhe Li , Qing Xu , Chul Yu , Calvin Yee , Stephen L. Gwaltney, II , Brian W. Metcalf , Steven Richards , Matthew A. Lardy , Lina Setti , Hing Sham
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61K31/437 , A61K31/4162
CPC classification number: C07D471/04 , C07D487/04 , C07D519/00
Abstract: In one aspect this invention relates generally to compounds of Formula: and sub-formulas thereof, or a tautomer of each thereof, a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, where X1, L1, L3, and R3 are described herein.
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公开(公告)号：US20230159538A1
公开(公告)日：2023-05-25
申请号：US17916530
申请日：2021-03-31
Applicant: Global Blood Therapeutics, Inc.
Inventor： Ming Yu , Brian Edwin Cathers , Zhe Li , Brian Walter Metcalf , Lina Q. Setti , Chul Yu , Manuel Zancanella
IPC: C07D487/04 , C07D519/00
CPC classification number: C07D487/04 , C07D519/00
Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US11111243B2
公开(公告)日：2021-09-07
申请号：US16002408
申请日：2018-06-07
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Chul Yu , Ming Yu , Manuel Zancanella , Zhe Li
IPC: C07D471/04 , A61P7/00 , C07D519/00 , C07D487/04
Abstract: The present disclosure provides certain angular tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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Patent Agency Ranking
公开(公告)号：US20180354947A1
公开(公告)日：2018-12-13
申请号：US16002408
申请日：2018-06-07
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Chul Yu , Ming Yu , Manuel Zancanella , Zhe Li
IPC: C07D471/04 , C07D487/04 , C07D519/00 , A61P7/00
CPC classification number: C07D471/04 , A61P7/00 , C07D487/04 , C07D519/00
Abstract: The present disclosure provides certain angular tricyclic compounds that are histone methyltransferases G9a and/or GLP inhibitors and are therefore useful for the treatment of diseases treatable by inhibition of G9a and/or GLP such as cancers and hemoglobinopathies (e.g., beta-thalassemia and sickle cell disease). Also provided are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
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公开(公告)号：US20180194780A1
公开(公告)日：2018-07-12
申请号：US15807331
申请日：2017-11-08
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Zhe Li , Manuel Zancanella , Chul Yu , Lina Q. Setti , Hing Sham , Qing Xu , Calvin W. Yee , Ming Yu
IPC: C07D519/00 , C07D493/08 , C07D491/18 , C07D487/08 , C07D471/08 , C07B59/00 , C07D401/12 , C07D307/81 , C07D213/73 , C07D405/12
CPC classification number: C07D519/00 , C07B59/002 , C07B2200/05 , C07D213/73 , C07D307/81 , C07D401/12 , C07D405/12 , C07D471/08 , C07D487/08 , C07D491/18 , C07D493/08
Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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公开(公告)号：US20240408107A1
公开(公告)日：2024-12-12
申请号：US18698516
申请日：2022-10-05
Applicant: Global Blood Therapeutics, Inc.
Inventor： Shahul Nilar , Lina Q. Setti , Chul Yu , Ming Yu
IPC: A61K31/553 , A61K31/4162 , A61K31/428 , A61K31/4725 , C07D487/04
Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US20230278984A1
公开(公告)日：2023-09-07
申请号：US18019379
申请日：2021-08-03
Applicant: Global Blood Therapeutics, Inc.
Inventor： Lina Q. Setti , Brian Cathers , Zhe Li , Shahul Nilar , James Partridge , Chul Yu , Ming Yu , Manuel Zancanella
IPC: C07D401/14 , C07D257/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D249/08
CPC classification number: C07D401/14 , C07D257/04 , C07D403/14 , C07D405/14 , C07D417/14 , C07D249/08
Abstract: The subject matter described herein is directed to pyruvate kinase activating compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for the treatment of diseases associated with PKR and/or PKM2, such as pyruvate kinase deficiency, sickle cell disease, and beta-thalassemia.
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公开(公告)号：US10144746B2
公开(公告)日：2018-12-04
申请号：US15807331
申请日：2017-11-08
Applicant: GLOBAL BLOOD THERAPEUTICS, INC.
Inventor： Zhe Li , Manuel Zancanella , Chul Yu , Lina Q. Setti , Hing Sham , Qing Xu , Calvin W. Yee , Ming Yu
IPC: C07D519/00 , C07D405/12 , C07D307/81 , C07D491/18 , C07D493/08 , C07D471/08 , C07D213/73 , C07B59/00 , C07D401/12 , C07D487/08
Abstract: Provided herein are kallikrein modulating compounds, pharmaceutical compositions comprising the same, and uses thereof.
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