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公开(公告)号：US11904281B2
公开(公告)日：2024-02-20
申请号：US17573378
申请日：2022-01-11
申请人： Fenwal, Inc.
CPC分类号： B01D63/16 , B01D61/20 , B01D2311/02 , B01D2311/14 , B01D2313/10 , B01D2313/243 , B01D2313/44 , B01D2313/90
摘要： A priming subsystem of a cell processing system carries out a method for priming a spinning membrane separator having an inlet and first and second outlets. The method includes opening a first selectable junction disposed between a priming fluid container and the inlet to open a path between the priming fluid container and the inlet, operating a first pump coupled to the first outlet to draw priming fluid from the priming fluid container into the spinning membrane separator, and closing the first selectable junction and a second selectable junction coupled to the second outlet after drawing the priming fluid into the spinning membrane separator. The method further includes operating the first pump after the first selectable junction is closed to draw a vacuum, and opening the first selectable junction after drawing the vacuum.
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公开(公告)号：US11745178B2
公开(公告)日：2023-09-05
申请号：US16713071
申请日：2019-12-13
申请人： Fenwal, Inc.
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01L2300/041 , B01L2300/06 , B01L2300/0848 , B01L2300/123 , B01L2400/0475 , B01L2400/06
摘要： A fluid processing cassette includes first and second covers, with an interior wall positioned between the covers. The interior wall includes a first surface facing the first cover and defining a portion of a plurality of macrofluidic channels. A second surface of the interior wall faces the second cover and defines a portion of a plurality of microfluidic channels. At least one opening defined in the interior wall provides fluid communication between at least one of the macrofluidic channels and at least one of the microfluidic channels. An additional interior wall may also be positioned between the covers, with each interior wall secured to a different one of the covers and to the other interior wall. The additional interior wall may be positioned between the first cover and the interior wall, with macrofluidic channels defined on each side of the additional interior wall.
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公开(公告)号：US11672891B2
公开(公告)日：2023-06-13
申请号：US17398780
申请日：2021-08-10
申请人： Fenwal, Inc.
CPC分类号： A61M1/00 , A61M1/0272 , A61M1/262 , A61M1/265 , A61M1/34 , A61M1/3692 , A61M1/3693 , G16H10/40 , A61M2205/75
摘要： A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.
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公开(公告)号：US11191879B2
公开(公告)日：2021-12-07
申请号：US15456853
申请日：2017-03-13
申请人： Fenwal, Inc.
摘要： A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.
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公开(公告)号：US20210106747A1
公开(公告)日：2021-04-15
申请号：US17128377
申请日：2020-12-21
申请人： Fenwal, Inc.
摘要： The present disclosure relates to systems and methods for the separation of blood into blood products and, more particularly, to systems and methods that permit automated recovery of white blood cells after producing a leukocyte-reduced blood product.
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公开(公告)号：US10697447B2
公开(公告)日：2020-06-30
申请号：US14464753
申请日：2014-08-21
申请人： Fenwal, Inc.
摘要： A system is provided for pumping fluid, with the system including a fluid pump and a cassette. The pump includes a motor and a piston that is movable toward and away from a flexible diaphragm of the cassette. A linkage connects the motor and the piston to move the piston toward and away from the diaphragm. At least a portion of the piston or the diaphragm is magnetized, with the other having at least a portion that is magnetized or formed of a ferromagnetic material, thereby magnetically coupling the piston and the diaphragm such that movement of the piston moves the diaphragm into and out of a cassette cavity aligned with the diaphragm and piston. Movement of the diaphragm into and out of the cavity changes the effective volume of the cavity, which has the effect of drawing fluid into or forcing fluid out of the cavity.
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公开(公告)号：US10449283B2
公开(公告)日：2019-10-22
申请号：US15498918
申请日：2017-04-27
申请人： Fenwal, Inc.
发明人： Christopher J. Wegener , Bret M. Olson , Alaina Schlinker , Steven Binninger , Avnie A. Kadakia , Kyle Thompson , Kyle Wolok , Melanie Hamilton
摘要： A cell processing system includes at least one processor connectable to a source container filled with a biological fluid, the at least one processor including a spinning membrane configured to receive and separate target cells from the biological fluid, the target cells exiting at a first outlet, one or more containers selectively connected to the first outlet; and, and a magnet. The system also includes a controller coupled to the at least one processor and configured to operate the spinning membrane to receive biological fluid from the source container and to direct the target cells to one of the one or more containers, to pause to permit magnetic particles to be associated with the target cells, and to operate the spinning membrane to receive the contents of one of the one or more containers with the magnet applied to the target cells associated with the magnetic particles.
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公开(公告)号：US10274495B2
公开(公告)日：2019-04-30
申请号：US15498965
申请日：2017-04-27
申请人： Fenwal, Inc.
IPC分类号： G01N33/543 , G01N33/569 , C12M1/00 , C12M1/36 , A61M1/02 , A61M1/34 , A61M1/26 , A61M1/36
摘要： A cell processing system includes a first processor connectable to a source container filled with a biological fluid, a second processor, and a controller coupled to the processors. The first processor includes a separator configured to separate the biological fluid into at least two streams of material, and a first container configured to receive one of the streams. The second processor includes a magnetic separator configured to select target cells, the target cells being associated with magnetic particles, a second, pass-through container associated with the magnetic separator, the second container connected at a first end to the first container, and a third container connected to a second end of the pass-through container. One of the processors includes at least one pump configured to transfer material between the separator and the first container, and between the first container and the second container.
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公开(公告)号：US20190099545A1
公开(公告)日：2019-04-04
申请号：US16143849
申请日：2018-09-27
申请人： Fenwal, Inc.
摘要： Automated systems and methods for processing a biological cell suspension are disclosed. The systems and methods allow for the processing of large volumes of a biological cell suspension contained in or more source containers.
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10.发明申请公开(公告)号：US20170128656A1
公开(公告)日：2017-05-11
申请号：US15122060
申请日：2014-04-30
申请人： Fenwal, Inc.
CPC分类号： A61M1/3496 , A61M1/0218 , A61M1/265 , A61M1/3633 , A61M2202/0429 , A61M2205/7563 , B01D63/16 , B01D65/08 , B01D71/34 , B01D71/50 , B01D2315/02 , B01D2321/2033
摘要： A system and method are provided for controlling fouling and complement protein activation during separation of plasma from whole blood using a spinning membrane separator. The separator includes a pair of relatively rotating surfaces spaced apart to define a gap therebetween, with at least one of the surfaces comprising a membrane that allows plasma to pass therethrough but substantially prevents the passage of red cells. In accordance with the method, the membrane material and membrane fabrication technique are selected so as that the resulting membrane both resists fouling and complement protein activation. In a specific embodiment, the membrane is has a smooth surface and substantially linear pores. The pores have a nominal diameter of less than 2 microns (so as to exclude platelets) and preferably a diameter of from 0.6 microns to 0.8 microns, as may be obtained by use of track-etching. In addition, the membrane material preferably is polycarbonate, as it has been determined that polycarbonate does not activate complement proteins.
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