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公开(公告)号：US11666668B2
公开(公告)日：2023-06-06
申请号：US15733173
申请日：2018-11-23
发明人： Norbert Windhab , Andreas Karau , Peter Hölig , Benedikt Hartwig , Julia Lyubina
CPC分类号： A61K49/1827 , A61B5/055 , A61B5/4866 , G01N24/10 , G01R33/60
摘要： A body has multiple phases, which have different electron spin resonance spectra that do not result from the simple combination of the ESR spectra of each individual phase.
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公开(公告)号：US11771801B2
公开(公告)日：2023-10-03
申请号：US16617726
申请日：2018-06-14
发明人： Balaji Prabhu , Andrew Wood , Mahrokh Dadsetan , Andreas Karau , Harsh Patel , Marc Knebel , Suneel Bandi
CPC分类号： A61L27/26 , A61L27/16 , A61L27/18 , A61L27/34 , C08L23/06 , C08L71/12 , C08L2203/02 , C08L2205/025 , C08L2205/035
摘要： The present invention comprises a polymer and/or polymer composite based sleeve to be fitted between an extended body, such the neck, trunnion, and/or stem of a hip implant, and a receiving body, such as a femoral head in a hip implant, that reduces wear, decreases toxic material from wear debris, enhances the mechanical connection of the extension and receiving body, reduces or eliminates impingement with receiving body, delocalize stress concentrations, and may also serve as a modifying junction between an extension and receiving body of unmatched size. The polymeric based sleeve presently disclosed comprises an inert and/or biologically favorable material which may be used in its virgin form or contain biocompatible additives. In order to best match patient and implant requirements, modifications may be made in the length, thickness, composition, as well as the presence of a taper, or lack thereof, in order to be compatible with existing devices.
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公开(公告)号：US11642436B2
公开(公告)日：2023-05-09
申请号：US16608830
申请日：2018-04-27
发明人： Teng Xue , Gianluigi Luppi , Natalia Ruggeri Savietto , Howard K. Bowman, III , Paul Joseph Spencer , Andreas Karau , Jian-Feng Zhang , Rosario Lizio , Marshall Scott Jones
IPC分类号： A61L24/00 , B33Y70/00 , B29C64/106 , A61B17/00 , A61F2/00 , A61L24/04 , A61L27/18 , A61L27/54 , A61L27/58 , C08G63/685 , C08G63/692 , C08G63/695 , B33Y10/00 , B33Y80/00 , B29K67/00 , B29K71/00 , B29K105/00 , B29L31/00
CPC分类号： A61L24/0042 , A61B17/00491 , A61F2/0095 , A61L24/0015 , A61L24/046 , A61L27/18 , A61L27/54 , A61L27/58 , B29C64/106 , B33Y70/00 , C08G63/6852 , C08G63/6922 , C08G63/6952 , A61B2017/00495 , B29K2067/043 , B29K2067/046 , B29K2071/02 , B29K2105/0035 , B29K2995/006 , B29L2031/753 , B33Y10/00 , B33Y80/00
摘要： The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
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公开(公告)号：US20210046218A1
公开(公告)日：2021-02-18
申请号：US16963285
申请日：2019-02-01
发明人： Balaji Prabhu , Andrew Wood , Mahrokh Dadsetan , Andreas Karau , Suneel Bandi , Kenneth Ross , Marc Knebel
摘要： The present invention comprises a polymeric based femoral and/or tibial component implant to be used in total knee replacement/arthroplasty procedures serving to provide increased wear resistance, enhanced physiological response at the bone/implant interface, and decreased stress-shielding. The implant can be made via additive manufacturing. The articulating surface of the implant may be implemented in without any additive or in a form containing an additive for improved tribological response. Further, the device disclosed herein contains an interfacial surface which is in contact with the native bone (i.e., bone/implant interface) which may exist in its pure form, containing a bioactive additive. The implant has a porous morphology on the bone/implant interface for improved biological response and improved fixation. The depth of the additives and the topographical morphology therein are controlled via techniques disclosed herein.
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公开(公告)号：US20210015969A1
公开(公告)日：2021-01-21
申请号：US16517124
申请日：2019-07-19
IPC分类号： A61L27/26 , A61L27/54 , A61K47/36 , A61K47/34 , B33Y10/00 , B29C64/153 , B29C64/165 , B29C64/118 , B29C51/00 , B29C45/00 , B29C48/00 , B33Y70/00 , B33Y80/00
摘要： This invention relates to the composition of flexible resorbable polymers with rigid resorbable fillers. The invention further relates to processing of flexible resorbable polymers with rigid resorbable fillers. The invention relates also to the use of such materials for applications in fast degradation applications. The invention also relates to the composition of flexible resorbable polymers with rigid resorbable for making shape memory materials. This invention also related to the processing of such materials by extrusion, injection molding, thermoforming, solvent mixing, and additive manufacturing. The invention also relates to the use of such materials as bone filler, vascular closure and other hemostasis devices, aneurysms, and stent applications. The invention also relates to the use of such materials as drug delivery platforms.
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公开(公告)号：US20230310696A1
公开(公告)日：2023-10-05
申请号：US18139764
申请日：2023-04-26
发明人： Teng Xue , Gianluigi Luppi , Natalia Ruggeri Savietto , Howard K. Bowman, III , Paul Joseph Spencer , Andreas Karau , Jian-Feng Zhang , Rosario Lizio , Marshall Scott Jones
IPC分类号： A61L24/00 , B33Y70/00 , B29C64/106 , A61B17/00 , A61F2/00 , A61L24/04 , A61L27/18 , A61L27/54 , A61L27/58 , C08G63/685 , C08G63/692 , C08G63/695
CPC分类号： A61L24/0042 , A61B17/00491 , A61F2/0095 , A61L24/0015 , A61L24/046 , A61L27/18 , A61L27/54 , A61L27/58 , B29C64/106 , B33Y70/00 , C08G63/6852 , C08G63/6922 , C08G63/6952 , B33Y10/00
摘要： The present invention is directed to bioresorbable polymers to be used as bone and tissue adhesives. The present invention is also directed to the synthesis of bioresorbable polymeric molecules bearing adhesive moieties and the use of such compounds in methods to glue and stabilize fractured bones and damaged tissues. The present invention is also directed to the use of such compounds as adhesive sealants for applications in wound care. The present invention is also directed to the use of such compounds as biodegradable ink for applications in tissue engineering and 3D printing. The present invention also relates to the use of such compounds as drug delivery platforms.
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公开(公告)号：US20210130608A1
公开(公告)日：2021-05-06
申请号：US16644017
申请日：2018-08-31
发明人： Rafael Gentsch , Mohammad Nikoukar , Kevin Acreman , Milin Shah , Tom Tice , Harsh Patel , Andreas Karau , Rosario Lizio
摘要： The present invention is directed to biocompatible polymeric powders to be used for 3D printing applications. More specifically, the 3D printing process will allow a tool less manufacturing of medical devices in particular in the implantables or regenerative space. Its flow and other processing characteristics qualifies them for the use in selective laser sintering, but also could be suitable for other powder based 3D printing technologies.
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公开(公告)号：US20210122916A1
公开(公告)日：2021-04-29
申请号：US17256957
申请日：2019-06-28
摘要： The present invention is directed to bioresorbable polymer blend compositions with tunable mechanical properties for manufacturing medical devices. These blends are multicomponent blends, comprise multiple polymer components and may or may not require additives in the form of fibers or particles for the potential enhancement of mechanical and/or biological properties.
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公开(公告)号：US20210008252A1
公开(公告)日：2021-01-14
申请号：US17040190
申请日：2019-03-25
发明人： Balaji Prabhu , Mahrokh Dadsetan , Subhadip Bodhak , Andreas Karau , Marc Knebel , Rosario Lizio , Samuel von Karsa-Wilberforce
摘要： Composite materials comprising thermoplastic polymeric material such as polyaryletherketones (PAEKs) and inorganic additive species serving to increase the processing and resultant mechanical, thermal, and biological properties of said thermoplastic polymeric material which may be subsequently used in various medical applications after the two materials are mixed through thermal processing methods. The inorganic additive species may be a calcium salt, and may include fluorine ions.
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公开(公告)号：US20220257830A1
公开(公告)日：2022-08-18
申请号：US17627800
申请日：2020-07-14
IPC分类号： A61L27/26 , B33Y10/00 , B33Y70/00 , B33Y80/00 , B29C64/118 , B29C64/153 , B29C64/165 , B29C48/00 , A61K47/34 , A61K47/36 , A61L27/54 , B29C45/00 , B29C51/00 , C08L1/02 , C08L3/02
摘要： This invention relates to the composition of flexible resorbable polymers with rigid resorbable fillers. The invention further relates to processing of flexible resorbable polymers with rigid resorbable fillers. The invention relates also to the use of such materials for applications in fast degradation applications. The invention also relates to the composition of flexible resorbable polymers with rigid resorbable for making shape memory materials. This invention also related to the processing of such materials by extrusion, injection molding, thermoforming, solvent mixing, and additive manufacturing. The invention also relates to the use of such materials as bone filler, vascular closure and other hemostasis devices, aneurysms, and stent applications. The invention also relates to the use of such materials as drug delivery platforms.
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