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    System and method for evaluating agents which prevent oxidative damage
    2.
    发明授权
    System and method for evaluating agents which prevent oxidative damage 失效
    用于评估预防氧化损伤的药剂的系统和方法

    公开(公告)号：US06753146B1

    公开(公告)日：2004-06-22

    申请号：US09913472

    申请日：2002-01-28

    Applicant: Eric F. Bernstein

    Inventor： Eric F. Bernstein

    IPC: C12Q168

    CPC classification number: G01N33/5044 ,  C12N2830/008 ,  G01N33/5008 ,  G01N33/502 ,  G01N2333/78

    Abstract: An in vitro system for identifying agents capable of inhibiting or preventing oxidative damage is provided. The disclosed in vitro system comprises a mouse fibroblast culture derived from a transgenic mouse capable of expressing a reporter gene regulated by a human elastin promoter and a chemical means for generating reactive oxygen species within the mouse fibroblast culture. Also disclosed is a method for using this in vitro system for identifying agents capable of inhibiting or preventing oxidative damage. The disclosed method comprises adding a test agent suspected of providing protection against oxidative damage to the mouse fibroblast culture, adding a chemical means for generation of reactive oxygen species to the culture, determining human elastin promoter activity in the culture exposed to the test agent after a selected time period, and comparing the determined human elastin promoter activity in the culture exposed to the test agent to the activity of the same promoter in a control fibroblast culture wherein a decrease in the determined human elastin promoter activity is indicative of the test agent inhibiting or preventing oxidative damage.

    Abstract translation: 提供了用于鉴定能够抑制或预防氧化损伤的试剂的体外系统。 所公开的体外系统包括衍生自能够表达由人弹性蛋白启动子调节的报告基因的转基因小鼠的小鼠成纤维细胞培养物和用于在小鼠成纤维细胞培养物内产生活性氧的化学方法。 还公开了一种使用该体外系统鉴定能够抑制或预防氧化损伤的试剂的方法。 所公开的方法包括向怀疑对小鼠成纤维细胞培养物添加怀疑提供抗氧化损伤保护的试验剂，向培养物中加入产生活性氧的化学方法，测定暴露于试验剂后的培养物中的人弹性蛋白启动子活性 选择的时间段，并将暴露于测试试剂的培养物中测定的人弹性蛋白启动子活性与对照成纤维细胞培养物中相同启动子的活性进行比较，其中测定的人弹性蛋白启动子活性的降低指示测试试剂抑制或 防止氧化损伤。

    LASER TREATMENT OF VASCULAR LESIONS, PIGMENTED LESIONS AND HAIR WITH A PULSED-DYE LASER
    4.
    发明申请
    LASER TREATMENT OF VASCULAR LESIONS, PIGMENTED LESIONS AND HAIR WITH A PULSED-DYE LASER 审中-公开
    用脉冲激光激光治疗血管内皮细胞，刺激的乳头和头发

    公开(公告)号：US20080312641A1

    公开(公告)日：2008-12-18

    申请号：US12137626

    申请日：2008-06-12

    Applicant: Eric F. Bernstein

    Inventor： Eric F. Bernstein

    IPC: A61B18/20

    CPC classification number: A61B18/203 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/00476 ,  A61B2018/207

    Abstract: There is disclosed a method of treating one or more skin conditions using pulsed, scanned, or continuously administered laser light in multiple wavelength ranges. The skin conditions that can be treated include vascular lesions and/or dermal remodeling by administering to the skin, energy having a wavelength ranging from 570-598 nanometers, and reducing or removing unwanted hair by administering to the skin energy having a wavelength ranging from 550-560 nanometers or from 598-1100 nanometers. The various energies are provided by the same laser and can be administered in any order or simultaneously.

    Abstract translation: 公开了一种使用脉冲，扫描或连续施用的多个波长范围的激光治疗一种或多种皮肤病症的方法。 可以治疗的皮肤状况包括血管损伤和/或皮肤重塑，通过向皮肤施加波长范围为570-598纳米的能量，并通过向皮肤施用波长范围为550的能量来减少或去除不需要的毛发 -560纳米或598-1100纳米。 各种能量由相同的激光器提供，并且可以以任何顺序或同时施用。

    Triplet quencher for use in lasers
    6.
    发明授权
    Triplet quencher for use in lasers 有权
    用于激光器的三重猝灭剂

    公开(公告)号：US07792175B2

    公开(公告)日：2010-09-07

    申请号：US12056358

    申请日：2008-03-27

    Applicant: Eric F. Bernstein

    Inventor： Eric F. Bernstein

    IPC: H01S3/20 ,  G03G5/00

    CPC classification number: H01S3/213

    Abstract: There are disclosed compounds for assisting triplet absorption in a laser, such as a pulsed-dye laser, the compounds comprising at least one molecule chosen from nitroxides and nitrones. In one embodiment, the disclosed compounds may be mixed with the dye of a dye laser in an amount sufficient to assist in triplet absorption. In one embodiment, the nitroxide compound comprises tempol[4-hydroxy-2,2,6,6-tetramethyl-piperidinyloxy, free radical]. Also disclosed are methods of using the disclosed compounds to control the triplet absorption of a dye laser or improve the performance or life span of a gaseous or solid laser.

    Abstract translation: 公开了用于辅助激光的三重态吸收的化合物，例如脉冲染料激光，所述化合物包含至少一种选自硝基氧和硝酸根的分子。 在一个实施方案中，所公开的化合物可以与染料激光的染料以足以辅助三重态吸收的量混合。 在一个实施方案中，硝基氧化合物包含温溶醇[4-羟基-2,2,6,6-四甲基 - 哌啶基氧基，自由基]。 还公开了使用所公开的化合物来控制染料激光器的三线态吸收或改善气体或固体激光器的性能或寿命的方法。

    Use of nitroxides in treating skin disease
    7.
    发明授权
    Use of nitroxides in treating skin disease 有权
    使用硝基氧治疗皮肤病

    公开(公告)号：US07285544B2

    公开(公告)日：2007-10-23

    申请号：US10991822

    申请日：2004-11-18

    Applicant: Eric F. Bernstein

    Inventor： Eric F. Bernstein

    IPC: A61K31/56 ,  A61K31/445 ,  A61K33/40

    CPC classification number: A61K31/573 ,  A61K31/13 ,  A61K31/19 ,  A61K31/4745 ,  A61K2300/00

    Abstract: Methods of treating inflammatory skin diseases such as rosacea, atopic dermatitis, contact dermatitis, drug eruptions, psoriasis, seborrheic dermatitis, connective tissue diseases, autoimmune disorders, urticaria or hives, and inflammation associated with skin infections by topical or systemic administration of a nitroxide containing compound are provided.

    Abstract translation: 治疗炎性皮肤疾病如红斑痤疮，特应性皮炎，接触性皮炎，药物爆发，牛皮癣，脂溢性皮炎，结缔组织疾病，自身免疫性疾病，荨麻疹或荨麻疹等炎症性皮肤疾病以及与皮肤感染有关的炎症的局部或全身施用含有氮氧化物的方法 提供化合物。

    Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane
    8.
    发明授权
    Irradiance attachment for an optical fiber to provide a uniform level of illumination across a plane 失效
    用于光纤的辐射附件，以提供跨平面的均匀的照明水平

    公开(公告)号：US5519534A

    公开(公告)日：1996-05-21

    申请号：US248918

    申请日：1994-05-25

    Applicant: Paul D. Smith ,  John Cole ,  Frank Harrington ,  Eric F. Bernstein

    Inventor： Paul D. Smith ,  John Cole ,  Frank Harrington ,  Eric F. Bernstein

    IPC: A61B18/22 ,  A61N5/06 ,  G02B5/02 ,  A61B17/36 ,  A61N5/00 ,  G01J1/04

    CPC classification number: A61N5/062 ,  G02B5/02 ,  A61B2018/2261 ,  A61N2005/0644 ,  A61N2005/0666 ,  Y10S359/90

    Abstract: A irradiation attachment for an optical fiber which provides an output of light that has a highly uniform intensity. The device includes a hollow spherical shell having a diffusive reflective surface or target supported therein. Light is directed into the hollow spherical shell so that it reflects off the diffusive reflective surface or target. The reflected light is internally reflected off the inner surface of the hollow spherical shell several times before passing through an output aperture. As a result of the internal reflection within the hollow spherical shell, the light leaving the device has a highly uniform intensity. The device is particularly useful for photodynamic therapy.

    Abstract translation: 用于光纤的照射附件，其提供具有高度均匀强度的光的输出。 该装置包括具有支撑在其中的漫射反射表面或靶的中空球壳。 光被引导到中空球壳中，使得其反射离开漫射反射表面或靶。 在通过输出孔之前，反射光在中空球壳的内表面内部被反射几次。 由于在空心球壳内的内部反射，离开设备的光具有高度均匀的强度。 该装置对光动力疗法特别有用。

    Surface fluorescent monitor
    9.
    发明授权
    Surface fluorescent monitor 失效
    表面荧光显示器

    公开(公告)号：US5435307A

    公开(公告)日：1995-07-25

    申请号：US676581

    申请日：1991-03-29

    Applicant: Walter S. Friauf ,  Paul D. Smith ,  John W. Cole ,  Joseph F. Fessler ,  Roger E. Solomon ,  Eric F. Bernstein

    Inventor： Walter S. Friauf ,  Paul D. Smith ,  John W. Cole ,  Joseph F. Fessler ,  Roger E. Solomon ,  Eric F. Bernstein

    IPC: A61B5/00

    CPC classification number: A61B5/0059

    Abstract: A method of optimizing photodynamic therapy in which retained concentrations of photosensitizers administered are measured on a real time basis by percutaneous measurements of fluorescence. A light weight hand held fluorometer is used to percutaneously measure fluorescence emitted by photosensitizers in a tissue situs that is subject to photodynamic therapy. The use of real time determinations of the concentration of photosensitizers allow optimization of illumination intensity and duration.

    Abstract translation: 优化光动力疗法的方法，其中通过经皮测量荧光实时测量所施用的光敏剂的保留浓度。 使用轻量级的手持式荧光计经皮测量经受光动力学治疗的组织部位中的光敏剂发出的荧光。 使用光敏剂浓度的实时测定可以优化照明强度和持续时间。

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