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    MEDICAL LASER USER INTERFACE
    4.
    发明申请
    MEDICAL LASER USER INTERFACE 审中-公开
    医用激光用户界面

    公开(公告)号：US20170027644A1

    公开(公告)日：2017-02-02

    申请号：US15291624

    申请日：2016-10-12

    申请人： Boston Scientific Scimed, Inc.

    发明人： Michael R. Hodel ,  Terry J. Smith

    IPC分类号： A61B18/22

    CPC分类号： A61B34/25 ,  A61B18/22 ,  A61B2017/00115 ,  A61B2017/00973 ,  A61B2018/00589 ,  A61B2018/00625 ,  A61B2018/00916 ,  A61B2018/00958 ,  A61B2018/207 ,  A61B2018/225

    摘要： The medical laser user interface of the present invention generally comprises a medical laser unit and a control system. The medical laser unit includes an optical probe for delivering laser light to a patient's tissue. The control system controls operation of the medical laser unit. Specifically, the control system provides a foot pedal system that enables the user to switch between the delivery of a first wavelength of laser light and a second wavelength of laser light through depression of a foot pedal. In a first embodiment, a single foot pedal can be used to toggle the wavelengths, where as in a second embodiment two foot pedals can be use, one for the first wavelength and one for the second wavelength. The two wavelengths provided include a wavelength for vaporization of tissue and a wavelength for coagulation.

    摘要翻译： 本发明的医疗用激光用户界面通常包括医疗用激光单元和控制系统。 医疗激光单元包括用于将激光传送到患者组织的光学探针。 控制系统控制医疗用激光单元的动作。 具体地说，控制系统提供了一种脚踏踏板系统，其能够使用户通过按压脚踏板在第一波长的激光和第二波长的激光之间进行切换。 在第一实施例中，可以使用单脚踏板来切换波长，其中如在第二实施例中可以使用两个脚踏板，一个用于第一波长，一个用于第二波长。 所提供的两个波长包括用于组织蒸发的波长和用于凝结的波长。

    Multiwavelength Surgical Laser
    5.
    发明申请
    Multiwavelength Surgical Laser 有权
    多波长手术激光

    公开(公告)号：US20160184019A1

    公开(公告)日：2016-06-30

    申请号：US14945053

    申请日：2015-11-18

    申请人： InnovaQuartz LLC

    发明人： Stephen E. Griffin

    IPC分类号： A61B18/22

    CPC分类号： A61B18/20 ,  A61B18/22 ,  A61B2018/00547 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00601 ,  A61B2018/00625 ,  A61B2018/1807 ,  A61B2018/2015 ,  A61B2018/2065 ,  A61B2018/207 ,  A61B2018/208 ,  A61B2018/2205 ,  A61B2018/2244

    摘要： A multiwavelength laser-based intense light source is described having applications in incision, excision and ablation of soft tissues with minimal collateral tissue damage. The light source combines the output of a plurality of relatively low power laser sources, emitting radiation in the region of the electromagnetic spectrum bounded by approximately 350 nm to 450 nm, where the combined output may be coupled into a single fiber optic energy delivery device: a standard surgical probe. Spectral and spatial beam combining are used to produce an incoherent light source with relatively low average power at any given wavelength, but with high total power and superior M2 beam quality, targeting multiple chromophores in target tissue and tissue breakdown product chromophores for consistently high and target absorption without indiscriminant char interference throughout a surgical procedure.

    摘要翻译： 描述了基于多波长激光的强光源，其具有在具有最小侧支组织损伤的软组织的切割，切除和消融中的应用。 光源组合多个相对较低功率的激光源的输出，在由约350nm至450nm限定的电磁光谱区域中发射辐射，其中组合输出可耦合到单个光纤能量传递装置中： 标准手术探针。 光谱和空间光束组合用于产生在任何给定波长下具有相对较低平均功率的非相干光源，但是具有高总功率和优异的M2光束质量，靶向目标组织中的多个发色团和组织分解产物发色团一致地高和目标 在整个外科手术过程中吸收没有不分歧的焦虑干扰。

    Methods to Alter Damaged Mammalian Skin using a Multiphoton Processes
    8.
    发明申请
    Methods to Alter Damaged Mammalian Skin using a Multiphoton Processes 有权
    使用多光子过程改变损伤的哺乳动物皮肤的方法

    公开(公告)号：US20150289935A1

    公开(公告)日：2015-10-15

    申请号：US14728414

    申请日：2015-06-02

    申请人： Szymon Szymon Suckewer ,  Alexander Smits ,  Steven Hubert

    发明人： Szymon Szymon Suckewer ,  Alexander Smits ,  Steven Hubert

    IPC分类号： A61B18/20

    CPC分类号： A61B18/203 ,  A61B2017/00769 ,  A61B2018/00452 ,  A61B2018/00458 ,  A61B2018/0047 ,  A61B2018/00476 ,  A61B2018/00577 ,  A61B2018/2025 ,  A61B2018/20359 ,  A61B2018/207

    摘要： A system and method of altering damaged mammalian skin using a multiphoton processes is disclosed. A femtosecond laser initiates a multiphoton event using pulse energies of 2-5 mJ thereby causing multiphoton ablation without damaging surrounding tissue. The laser is focused to the vicinity of a target organelle that occurs naturally within the damaged skin, and is related to the dermatological condition being addressed. The type of organelle depends on the condition being addressed, and may be targeted by the depth beneath the surface of the skin at which it is located. The femtosecond laser beam is focused to an intensity of least 1012 W/cm2 to initiate the multiphoton event transforms the targeted organelle to mitigate the damage to the skin.

    摘要翻译： 公开了使用多光子过程改变受损的哺乳动物皮肤的系统和方法。 飞秒激光器使用2-5mJ的脉冲能量发起多光子事件，从而导致多光子消融而不损坏周围组织。 激光被聚焦到受损皮肤内自然发生的靶细胞器附近，并且与正在解决的皮肤病学疾病有关。 细胞器的类型取决于所处理的病症，并且可以由位于其的皮肤表面下方的深度定位。 将飞秒激光束聚焦到至少1012W / cm2的强度，以启动多光子事件转换靶细胞器以减轻对皮肤的损伤。

    NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS
    9.
    发明申请
    NEAR-INFRARED ELECTROMAGNETIC MODIFICATION OF CELLULAR STEADY-STATE MEMBRANE POTENTIALS 审中-公开
    细胞状态膜电位的近红外电磁修正

    公开(公告)号：US20150157876A1

    公开(公告)日：2015-06-11

    申请号：US14508163

    申请日：2014-10-07

    申请人： NOMIR MEDICAL TECHNOLOGIES, INC.

    发明人： Eric BORNSTEIN ,  John Wlassich

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0624 ,  A61B2018/00988 ,  A61B2018/20361 ,  A61B2018/207 ,  A61N5/0616 ,  A61N2005/0628 ,  A61N2005/063 ,  A61N2005/0643 ,  A61N2005/0644 ,  A61N2005/0645 ,  A61N2005/0659

    摘要： Systems and methods are disclosed herein for applying near-infrared optical energies and dosimetries to alter the bioenergetic steady-state trans-membrane and mitochondrial potentials (ΔΨ-steady) of all irradiated cells through an optical depolarization effect. This depolarization causes a concomitant decrease in the absolute value of the trans-membrane potentials ΔΨ of the irradiated mitochondrial and plasma membranes. Many cellular anabolic reactions and drug-resistance mechanisms can be rendered less functional and/or mitigated by a decrease in a membrane potential ΔΨ, the affiliated weakening of the proton motive force Δp, and the associated lowered phosphorylation potential ΔGp. Within the area of irradiation exposure, the decrease in membrane potentials ΔΨ will occur in bacterial, fungal and mammalian cells in unison. This membrane depolarization provides the ability to potentiate antimicrobial, antifungal and/or antineoplastic drugs against only targeted undesirable cells.

    摘要翻译： 本文公开了用于应用近红外光学能量和剂量测定法以通过光学去极化效应改变所有辐射细胞的生物能量稳态跨膜和线粒体电位（＆Dgr;Ψ稳定）的系统和方法。 这种去极化引起照射的线粒体和质膜的跨膜电位和Dgr的绝对值的同时降低。 许多细胞合成代谢反应和药物抗性机制可以通过膜电位降低而降低功能和/或减轻Ψ，质子动力和Dgr; p的相关弱化以及相关的降低的磷酸化潜能和Dgr; Gp 。 在照射暴露的范围内，细胞，真菌和哺乳动物细胞一致会发生膜电位降低和Ψ。 该膜去极化提供了针对仅靶向不期望的细胞增强抗微生物，抗真菌和/或抗肿瘤药物的能力。