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    BIOSENSOR DISEASE AND INFECTION SCREENING
    1.
    发明申请
    BIOSENSOR DISEASE AND INFECTION SCREENING 审中-公开

    公开(公告)号：US20190183394A1

    公开(公告)日：2019-06-20

    申请号：US16322943

    申请日：2017-08-02

    Applicant: Eccrine Systems, Inc.

    Inventor： Robert Beech ,  Evyn White ,  Benjamin Katchman

    IPC: A61B5/1477 ,  G01N33/573 ,  G01N33/543 ,  A61B5/145 ,  A61B5/00

    CPC classification number: A61B5/1477 ,  A61B5/14507 ,  A61B5/412 ,  A61B5/6833 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/573

    Abstract: The disclosed invention includes methods to employ wearable biosensing devices to accomplish the following: 1) screen for the presence of a disease or infection, including pre-symptomatic detection, and determination of the type (e.g., viral, bacterial, or fungal) of disease or infection present; 2) confirm the antigen and monitor the progress of an active infection; and 3) monitor the efficacy of a treatment program for a disease or infection. Such methods rely on the detection, in sweat or other biofluids, of proteins, nucleotides, DNA polymerases, proteases, group-specific antigens, antibodies, cytokines, or other molecules, that are produced by the body as part of the innate or adaptive immune responses to an infectious agent, or the infectious agent itself, its products, or derivatives. Some embodiments comprise a method of using such a biosensing device as a biosentinel against biological threats.

    DOCKED APTAMER EAB BIOSENSORS
    3.
    发明申请
    DOCKED APTAMER EAB BIOSENSORS 有权

    公开(公告)号：US20210285936A1

    公开(公告)日：2021-09-16

    申请号：US16624062

    申请日：2018-06-25

    Applicant: Eccrine Systems, Inc.

    Inventor： Robert Beech ,  Mikel Larson ,  Jacob A Bertrand ,  Gavi Begtrup

    IPC: G01N33/53 ,  G01N33/543 ,  G01N27/327

    Abstract: Electrochemical aptamer-based biosensing devices and methods are described herein that are configured to produce a detectible signal upon target analyte interaction, with reduced reliance on a conformational change by the aptamer. The disclosure includes embodiments of docked aptamer EAB sensors for measuring the presence of a target analyte in a biofluid sample. The sensors include an electrode capable of sensing redox events, and a plurality of aptamer sensing elements with aptamers selected to interact with a target analyte. Each aptamer sensing element includes a molecular docking structure attached to the electrode, and an analyte capture complex that includes an aptamer releasably bound to the docking structure, and an electroactive redox moiety. Upon the aptamer binding with a target analyte, the analyte capture complex separates from the docking structure. The separation of the analyte capture complex from the docking structure produces a positional change in the redox moiety that is detectable by the sensing device on interrogation of the electrode.

    BIOFLUID SENSING DEVICE NUCLEOTIDE SENSING APPLICATIONS
    4.
    发明申请
    BIOFLUID SENSING DEVICE NUCLEOTIDE SENSING APPLICATIONS 审中-公开

    公开(公告)号：US20190117132A1

    公开(公告)日：2019-04-25

    申请号：US16083382

    申请日：2017-03-09

    Applicant: Eccrine Systems, Inc.

    Inventor： Robert Beech ,  Gavi Begtrup ,  Benjamin Katchman

    IPC: A61B5/1477 ,  A61B5/00 ,  A61B5/145 ,  A61B5/117

    Abstract: The disclosed invention addresses an unmet need of biofluid analysis by utilizing the presence of certain nucleotides, e.g., microDNA, eccDNA, DNA fragments, microRNA, RNA fragments, and peptides, in a sample biofluid, such as eccrine sweat, apocrine sweat, blood, serum, saliva or tears, to perform a number of physiological sensing functions. Specifically, the present disclosure provides: (1) a device and method of determining whether a biofluid sensing device is being worn by a specific individual based on a measurement of nucleotides in a biofluid; (2) a device and method of recognizing at least one physiological disease or condition based on nucleotide concentrations, ratios, or trends in a biofluid.

    EAB SENSING DEVICES WITH BIOFLUID SAMPLE CONCENTRATION
    5.
    发明申请
    EAB SENSING DEVICES WITH BIOFLUID SAMPLE CONCENTRATION 审中-公开

    公开(公告)号：US20200155046A1

    公开(公告)日：2020-05-21

    申请号：US16484989

    申请日：2018-02-07

    Applicant: Eccrine Systems, Inc.

    Inventor： Robert Beech ,  Gavi Begtrup ,  Jason Heikenfeld ,  Jacob A. Bertrand

    IPC: A61B5/145 ,  A61B5/01 ,  A61B5/00 ,  A61B5/1477

    Abstract: The present invention provides a biofluid sensing device capable of concentrating a biofluid sample with respect to a target analyte, so that the analyte can be accurately detected or measured by EAB sensors. Methods for using such a device provide qualitative information about the presence of the analyte, and/or quantitative information about relative concentrations of the analyte in the biofluid. The disclosed device includes a concentration channel for concentrating the biofluid sample, as well as a selectively permeable membrane, one or more EAB sensors, and one or more secondary sensors carried on a water-impermeable substrate. A method for using the disclosed device to collect a biofluid sample, concentrate the sample relative to a target analyte, and measure the target analyte is also disclosed.

    DYNAMIC SWEAT SENSING DEVICE MANAGEMENT
    7.
    发明申请
    DYNAMIC SWEAT SENSING DEVICE MANAGEMENT 审中-公开

    公开(公告)号：US20180263538A1

    公开(公告)日：2018-09-20

    申请号：US15553210

    申请日：2016-02-24

    Applicant: Eccrine Systems, Inc.

    Inventor： Jason Heikenfeld ,  Robert Beech

    IPC: A61B5/145 ,  A61B5/00

    CPC classification number: A61B5/14517 ,  A61B5/0531 ,  A61B5/14521 ,  A61B5/1477 ,  A61B5/4266 ,  A61B5/6843 ,  A61B2560/0204 ,  A61B2560/0209

    Abstract: The disclosure provides: a two-way communication means between a sweat sensing device and a user; at least one means of activating, deactivating, controlling the sampling rate, and controlling the electrical power applied to a particular sweat sensor or group of sensors; a means of isolating a sweat sensor from sweat until needed; a means of selectively stimulating sweat for a particular sweat sensor or group of sensors to manage sweat flow or generation rate; a means of monitoring the power consumption of a sensor device, individual sensors or groups of sensors; a means of monitoring an individual sweat sensor or group of sensors for optimal performance; a means of monitoring whether a sweat sensing patch is in adequate proximity to a wearer's skin to allow device operation; and the ability to use aggregated sweat sensor data correlated with external information to enhance the device's management capabilities.

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