公开(公告)号：US20200080987A1

公开(公告)日：2020-03-12

申请号：US16344871

申请日：2017-10-25

Applicant: Eccrine Systems, Inc.

Inventor： Kathy Cunningham ,  Gavi Begtrup ,  Benjamin Katchman

IPC: G01N33/487 ,  G16H50/30

Abstract: The present disclosure provides a method of using a wearable biofluid sensing device to develop a cytokine profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more cytokines in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop (1) a baseline cytokine profile characterizing the individual's healthy cytokine levels, or (2) an inflammation profile for a physiological condition, which characterizes the expected cytokine levels for a physiological condition. Also included is a method to use a biofluid sensing device to determine whether an individual has a physiological condition by comparing device measurements to the baseline profile and inflammation profile. Results are then communicated to a device user.

公开(公告)号：US20200077936A1

公开(公告)日：2020-03-12

申请号：US16469940

申请日：2017-12-14

Applicant: Eccrine Systems, Inc.

Inventor： Kathy A Cunningham ,  Benjamin Katchman ,  Gavi Begtrup

IPC: A61B5/20 ,  A61B5/145 ,  A61B5/00 ,  A61B5/01 ,  A61B5/053

Abstract: The present disclosure provides a method of using a sweat sensing device to determine a kidney profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more kidney biomarkers in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop a kidney function profile or a kidney injury profile indicative of the physiological state of the individual.

公开(公告)号：US20190183394A1

公开(公告)日：2019-06-20

申请号：US16322943

申请日：2017-08-02

Applicant: Eccrine Systems, Inc.

Inventor： Robert Beech ,  Evyn White ,  Benjamin Katchman

IPC: A61B5/1477 ,  G01N33/573 ,  G01N33/543 ,  A61B5/145 ,  A61B5/00

CPC classification number: A61B5/1477 ,  A61B5/14507 ,  A61B5/412 ,  A61B5/6833 ,  G01N33/50 ,  G01N33/53 ,  G01N33/543 ,  G01N33/573

Abstract: The disclosed invention includes methods to employ wearable biosensing devices to accomplish the following: 1) screen for the presence of a disease or infection, including pre-symptomatic detection, and determination of the type (e.g., viral, bacterial, or fungal) of disease or infection present; 2) confirm the antigen and monitor the progress of an active infection; and 3) monitor the efficacy of a treatment program for a disease or infection. Such methods rely on the detection, in sweat or other biofluids, of proteins, nucleotides, DNA polymerases, proteases, group-specific antigens, antibodies, cytokines, or other molecules, that are produced by the body as part of the innate or adaptive immune responses to an infectious agent, or the infectious agent itself, its products, or derivatives. Some embodiments comprise a method of using such a biosensing device as a biosentinel against biological threats.

公开(公告)号：US20190117132A1

公开(公告)日：2019-04-25

申请号：US16083382

申请日：2017-03-09

Applicant: Eccrine Systems, Inc.

Inventor： Robert Beech ,  Gavi Begtrup ,  Benjamin Katchman

IPC: A61B5/1477 ,  A61B5/00 ,  A61B5/145 ,  A61B5/117

Abstract: The disclosed invention addresses an unmet need of biofluid analysis by utilizing the presence of certain nucleotides, e.g., microDNA, eccDNA, DNA fragments, microRNA, RNA fragments, and peptides, in a sample biofluid, such as eccrine sweat, apocrine sweat, blood, serum, saliva or tears, to perform a number of physiological sensing functions. Specifically, the present disclosure provides: (1) a device and method of determining whether a biofluid sensing device is being worn by a specific individual based on a measurement of nucleotides in a biofluid; (2) a device and method of recognizing at least one physiological disease or condition based on nucleotide concentrations, ratios, or trends in a biofluid.