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公开(公告)号：US20200080987A1
公开(公告)日：2020-03-12
申请号：US16344871
申请日：2017-10-25
Applicant: Eccrine Systems, Inc.
Inventor： Kathy Cunningham , Gavi Begtrup , Benjamin Katchman
IPC: G01N33/487 , G16H50/30
Abstract: The present disclosure provides a method of using a wearable biofluid sensing device to develop a cytokine profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more cytokines in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop (1) a baseline cytokine profile characterizing the individual's healthy cytokine levels, or (2) an inflammation profile for a physiological condition, which characterizes the expected cytokine levels for a physiological condition. Also included is a method to use a biofluid sensing device to determine whether an individual has a physiological condition by comparing device measurements to the baseline profile and inflammation profile. Results are then communicated to a device user.
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公开(公告)号：US20190254641A1
公开(公告)日：2019-08-22
申请号：US16403094
申请日：2019-05-03
Applicant: Eccrine Systems, Inc.
Inventor： Gavi Begtrup , Jason Heikenfeld , Austin Morgan
Abstract: The disclosed invention provides a biofluid sensing device configured with a membrane-enhanced sensor located in a sweat collector. The disclosed analyte-specific sensor is configured to reduce required biofluid sample volume due to its close proximity to the skin and source of sweat biofluid. The sensor is contained within a pH and salinity-stabilized fluid that, in turn, is contained in a selectively permeable membrane to improve sensor performance in variable biofluids, and to protect the sensor from skin contact. In one embodiment, the biofluid sensing device includes means to protect the self-aligning sensors from abrasion against the skin or device components. Other embodiments of the disclosed invention include a track-etched membrane to provide sensor protection.
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公开(公告)号：US20200077936A1
公开(公告)日：2020-03-12
申请号：US16469940
申请日：2017-12-14
Applicant: Eccrine Systems, Inc.
Inventor： Kathy A Cunningham , Benjamin Katchman , Gavi Begtrup
Abstract: The present disclosure provides a method of using a sweat sensing device to determine a kidney profile for an individual. The method includes taking concentration, ratio, and trend measurements of one or more kidney biomarkers in the individual's sweat, along with other contemporaneous device measurements to inform sweat rate, skin temperature, sweat sample pH, or other factors. The method further considers these measured values in the context of external information about the individual, and uses such information to develop a kidney function profile or a kidney injury profile indicative of the physiological state of the individual.
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公开(公告)号：US20180146898A1
公开(公告)日：2018-05-31
申请号：US15576146
申请日：2016-06-06
Applicant: Eccrine Systems, Inc.
Inventor： Gavi Begtrup , Robert Beech , Jason Heikenfeld
CPC classification number: A61B5/14521 , A61B5/0022 , A61B5/01 , A61B5/024 , A61B5/02405 , A61B5/0531 , A61B5/0533 , A61B5/1116 , A61B5/14517 , A61B5/14539 , A61B5/14546 , A61B5/165 , A61B5/4266 , A61B5/4809 , A61B5/6833 , A61B5/7275 , A61B5/7285 , A61B10/0064 , A61B2562/14 , G01N33/487
Abstract: The present disclosure includes a device and method of measuring an individual's cortisol awakening response; a device and method of measuring an individual's diurnal cortisone level, including the basal cortisol level; a device and method of indicating an individual's stress profile based on sweat cortisol measurements; a device for measuring and interpreting sweat analytes relevant to risk-taking behavior; and a method of determining an individual's risk-taking propensity based on measurement and development of sweat analyte profiles.
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5.发明申请公开(公告)号：US20180020966A1
公开(公告)日：2018-01-25
申请号：US15653494
申请日：2017-07-18
Applicant: Eccrine Systems, Inc.
Inventor： Gavi Begtrup , Jacob A. Bertrand , Jason Heikenfeld , Austin Morgan , Nathan Weinle
CPC classification number: A61B5/4266 , A61B5/01 , A61B5/0531 , A61B5/0533 , A61B5/14517 , A61B5/14539 , A61B5/14546 , A61B5/6801 , A61B5/7275 , A61B2503/04 , A61B2503/10 , A61B2562/0219 , A61B2562/14
Abstract: The disclosed invention includes sweat sensing devices configured to periodically measure sweat conductivity and galvanic skin response, devices to measure volumetric sweat flow rate, and devices that combine the three functions. The disclosure further includes methods for using a device configured to perform periodic sweat conductivity measurements, galvanic skin response measurements, and volumetric sweat rate measurements so that each sensor modality informs composite estimates of sweat onset, sweat cessation, sweat ion concentration, and sweat rate. The method uses those measurements to inform other sweat sensing device functions, such as determining the existence of a physiological condition, or performing measurements of concentrations, ratios, and trends of sweat analytes.
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Patent Agency Ranking
公开(公告)号：US20160374598A1
公开(公告)日：2016-12-29
申请号：US15186925
申请日：2016-06-20
Applicant: Eccrine Systems, Inc.
Inventor： Jason Heikenfeld , Gavi Begtrup , Jacob Bertrand
CPC classification number: A61B5/14521 , A61B5/01 , A61B5/0533 , A61B5/4266 , A61B5/486 , F24V30/00
Abstract: The disclosed invention provides sweat sensing devices with smart sweat stimulation and sensing embodiments: which improve the dependability and predictability of sweat sampling rates; achieve a desired number of sweat sampling events per day while minimizing skin irritation and prolonging device lifespan; and use physical, optical or thermal sweat stimulation to augment or replace chemical sweat stimulation.
Abstract translation: 所公开的发明提供了具有智能汗水刺激和感测实施例的汗液感测装置：其改善了汗液采样率的可靠性和可预测性; 实现每天所需数量的汗水采样事件，同时最大限度地减少皮肤刺激和延长设备寿命; 并使用物理，光学或热汗液刺激来增加或替代化学汗液刺激。
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公开(公告)号：US20210285936A1
公开(公告)日：2021-09-16
申请号：US16624062
申请日：2018-06-25
Applicant: Eccrine Systems, Inc.
Inventor： Robert Beech , Mikel Larson , Jacob A Bertrand , Gavi Begtrup
IPC: G01N33/53 , G01N33/543 , G01N27/327
Abstract: Electrochemical aptamer-based biosensing devices and methods are described herein that are configured to produce a detectible signal upon target analyte interaction, with reduced reliance on a conformational change by the aptamer. The disclosure includes embodiments of docked aptamer EAB sensors for measuring the presence of a target analyte in a biofluid sample. The sensors include an electrode capable of sensing redox events, and a plurality of aptamer sensing elements with aptamers selected to interact with a target analyte. Each aptamer sensing element includes a molecular docking structure attached to the electrode, and an analyte capture complex that includes an aptamer releasably bound to the docking structure, and an electroactive redox moiety. Upon the aptamer binding with a target analyte, the analyte capture complex separates from the docking structure. The separation of the analyte capture complex from the docking structure produces a positional change in the redox moiety that is detectable by the sensing device on interrogation of the electrode.
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公开(公告)号：US20210204840A1
公开(公告)日：2021-07-08
申请号：US16087342
申请日：2017-03-21
Applicant: Eccrine Systems, Inc.
Inventor： Jacob A. Bertrand , Gavi Begtrup , Leila Safazadeh Haghighi , Jason Heikenfeld
IPC: A61B5/1477 , G01N33/543 , A61B5/145 , A61B5/01 , A61B5/0533 , A61B5/00
Abstract: Challenges of the sweat medium for electrochemical aptamer-based biosensor (“EAB sensor”) devices can be mitigated through aptamer selection, sensor/device configuration and physiological algorithms that account for the effects of (1) target analyte size, (2) potential concentration ranges, (3) sweat sample pH, and (4) sweat sample salinity. The disclosed invention includes a method of aptamer selection for use in an EAB sensor configured for use in a wearable sweat sensing device. The disclosed invention further provides a sweat sensing device configured to use EAB sensors to detect target analytes in a sweat sample.
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公开(公告)号：US10674946B2
公开(公告)日：2020-06-09
申请号：US15382703
申请日：2016-12-18
Applicant: Eccrine Systems, Inc.
Inventor： Gavi Begtrup , Jason Heikenfeld
Abstract: The disclosed invention provides a sweat sensing device configured with self-aligned sweat stimulation means to provide adequate sweat generation for continuous monitoring of sweat. The disclosed device includes one or more analyte-specific sweat sensors that self-align with sweat glands. In one embodiment, the sweat sensing device includes means to protect the self-aligning sensors from abrasion against the skin or device components. In another embodiment, the device includes prolonged sweat stimulation for the self-aligning sensors through diffusion of a sweat stimulating compound into the skin.
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公开(公告)号：US20190117132A1
公开(公告)日：2019-04-25
申请号：US16083382
申请日：2017-03-09
Applicant: Eccrine Systems, Inc.
Inventor： Robert Beech , Gavi Begtrup , Benjamin Katchman
IPC: A61B5/1477 , A61B5/00 , A61B5/145 , A61B5/117
Abstract: The disclosed invention addresses an unmet need of biofluid analysis by utilizing the presence of certain nucleotides, e.g., microDNA, eccDNA, DNA fragments, microRNA, RNA fragments, and peptides, in a sample biofluid, such as eccrine sweat, apocrine sweat, blood, serum, saliva or tears, to perform a number of physiological sensing functions. Specifically, the present disclosure provides: (1) a device and method of determining whether a biofluid sensing device is being worn by a specific individual based on a measurement of nucleotides in a biofluid; (2) a device and method of recognizing at least one physiological disease or condition based on nucleotide concentrations, ratios, or trends in a biofluid.
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