公开(公告)号：US20050021028A1

公开(公告)日：2005-01-27

申请号：US10871697

申请日：2004-06-18

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61B20060101 ,  A61B17/00 ,  A61B17/30 ,  A61B18/14 ,  A61B18/18 ,  A61B19/00 ,  A61F9/00 ,  A61F9/007

CPC classification number: A61B17/30 ,  A61B18/12 ,  A61B18/14 ,  A61B34/70 ,  A61B90/30 ,  A61B2017/00176 ,  A61B2017/306 ,  A61B2018/1462 ,  A61F9/00 ,  A61F9/007

Abstract: An electro-adhesive tissue manipulator capable of manipulating tissue with a single conducting element is provided. The manipulator includes a conducting element, an electrical means and a control means capable of generating a first and a second pulse on demand. The first pulse generates an adhesive state between the conducting element and the tissue layer strong enough to manipulate the tissue layer. The second pulse, which has higher pulse energy than the first pulse, generates a non-adhesive state to detach the adhered tissue layer from the conducting element. The electro-adhesive device could be combined with a medical instrument to enhance the capabilities of the medical instrument so that it can manipulate tissue. The advantage of the present invention, in contrast to mechanical tools, is that tissue can be manipulated with a single tip of a conducting element, without folding and piercing of the tissue, thus avoiding damage to the tissue.

Abstract translation: 提供能够用单个导电元件操纵组织的电粘组织操纵器。 机械手包括导电元件，电气装置和能够根据需要产生第一和第二脉冲的控制装置。 第一脉冲在导电元件和组织层之间产生强度足以操纵组织层的粘合状态。 具有比第一脉冲更高的脉冲能量的第二脉冲产生非粘合状态以将粘附的组织层与导电元件分离。 电粘合装置可以与医疗器械组合以增强医疗器械的能力，使得其可以操纵组织。 与机械工具相比，本发明的优点在于，组织可以用传导元件的单个尖端来操纵，而不会折叠和刺穿组织，从而避免损坏组织。

公开(公告)号：US20080119842A1

公开(公告)日：2008-05-22

申请号：US11974611

申请日：2007-10-12

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61B17/28

CPC classification number: A61B17/30 ,  A61B18/12 ,  A61B18/14 ,  A61B34/70 ,  A61B90/30 ,  A61B2017/00176 ,  A61B2017/306 ,  A61B2018/1462 ,  A61F9/00 ,  A61F9/007

Abstract: An electro-adhesive tissue manipulation method capable of manipulating tissue with a single conducting element is provided. The manipulator includes a conducting element, a pulse generator and a controller capable of generating a first and a second pulse on demand. The first pulse generates an adhesive state between the conducting element and the tissue layer strong enough to manipulate the tissue layer. The second pulse, which has higher pulse energy than the first pulse, generates a non-adhesive state to detach the adhered tissue layer from the conducting element. The electro-adhesive device could be combined with a medical instrument to enhance the capabilities of the medical instrument so that it can manipulate tissue. Thereby tissue can be manipulated with a single tip of a conducting element, without folding and piercing of the tissue, thus avoiding damage to the tissue.

Abstract translation: 提供了能够用单个导电元件操作组织的电粘组织操作方法。 操纵器包括导电元件，脉冲发生器和能够根据需要产生第一和第二脉冲的控制器。 第一脉冲在导电元件和组织层之间产生强度足以操纵组织层的粘合状态。 具有比第一脉冲更高的脉冲能量的第二脉冲产生非粘合状态以将粘附的组织层与导电元件分离。 电粘合装置可以与医疗器械组合以增强医疗器械的能力，使得其可以操纵组织。 由此，可以用传导元件的单个尖端来操纵组织，而不会折叠和刺穿组织，从而避免损坏组织。

公开(公告)号：US20050203601A1

公开(公告)日：2005-09-15

申请号：US11035692

申请日：2005-01-13

Applicant: Daniel Palanker ,  Philip Huie ,  Alexander Vankov ,  Harvey Fishman

Inventor： Daniel Palanker ,  Philip Huie ,  Alexander Vankov ,  Harvey Fishman

IPC: A61N1/00 ,  A61N1/04 ,  A61N1/05 ,  A61N1/36

CPC classification number: A61N1/0543 ,  A61N1/36046

Abstract: An interface for selective excitation or sensing of neural cells in a biological neural network is provided. The interface includes a membrane with a number of channels passing through the membrane. Each channel has at least one electrode within it. Neural cells in the biological neural network grow or migrate into the channels, thereby coming into close proximity to the electrodes. Once one or more neural cells have grown or migrated into a channel, a voltage applied to the electrode within the channel selectively excites the neural cell(s) in that channel. The excitation of these neural cell(s) will then transmit throughout the neural network (i.e. cells and axons) that is associated with the neural cell(s) stimulated in the channel. An alternative interface provides cell excitation via an array of electrically conductive pillars on a substrate. The pillars have electrically insulated sides and exposed top surfaces, to provide selective cell excitation.

Abstract translation: 提供了一种生物神经网络中选择性激发或感应神经细胞的界面。 界面包括具有穿过膜的多个通道的膜。 每个通道内至少有一个电极。 生物神经网络中的神经细胞生长或迁移到通道中，从而接近电极。 一旦一个或多个神经细胞已经生长或迁移到通道中，施加到通道内的电极的电压选择性地激发该通道中的神经细胞。 然后，这些神经细胞的激发将通过与通道中刺激的神经细胞相关联的神经网络（即细胞和轴突）传递。 另一种界面通过衬底上的导电柱阵列提供电池激发。 支柱具有电绝缘的侧面和暴露的顶表面，以提供选择性的电池激发。

公开(公告)号：US20080039832A1

公开(公告)日：2008-02-14

申请号：US11784382

申请日：2007-04-06

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61B18/14

CPC classification number: A61B18/042 ,  A61B2018/00601 ,  A61B2018/00625 ,  A61B2018/00726 ,  A61B2018/122 ,  A61B2018/1472

Abstract: Described herein are methods and apparatus for cutting a material including biological tissue. The apparatus has a cutting electrode with an elongate cutting portion. A voltage pulse waveform (typically comprising repeated bursts of minipulses) having a low or very low duty-cycle is applied to the cutting electrode to cut the tissue or other material by producing a vapor cavity around the cutting portion of the electrode and ionizing a gas inside the vapor cavity to produce a plasma. A low duty cycle cutting waveform may prevent heat accumulation in the tissue, reducing collateral thermal damage. The duration of the burst of minipulses typically ranges from 10 μs to 100 μs, and the rep rate typically ranges from 1 KHz to 10 Hz, as necessary. The apparatus and method of invention may cut biological tissue while decreasing bleeding and maintaining a very shallow zone of thermal damage.

Abstract translation: 这里描述了用于切割包括生物组织的材料的方法和装置。 该设备具有切割电极，其具有细长的切割部分。 具有低或非常低占空比的电压脉冲波形（通常包括重复脉冲串的脉冲）被施加到切割电极，以通过在电极的切割部分周围产生蒸气腔并电离气体来切割组织或其它材料 在蒸气腔内部产生等离子体。 低占空比切割波形可以防止组织中的热积聚，减少附带的热损伤。 小脉冲脉冲的持续时间通常在10μA至100μA的范围内，根据需要，重复率通常在1KHz至10Hz的范围内。 本发明的装置和方法可以在减少出血并保持非常浅的热损伤区域的同时切割生物组织。

公开(公告)号：US20080027428A1

公开(公告)日：2008-01-31

申请号：US11787500

申请日：2007-04-16

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61B18/14

CPC classification number: A61B18/1402 ,  A61B2018/00083 ,  A61B2018/1407

Abstract: The present invention is directed towards an electrosurgical cutting system. The system comprises an electrically conductive blade, having an uninsulated cutting edge that is surrounded by an insulator. A source of pulsed electrical energy may be coupled to the electrically conductive blade to provide a substantially uniform and highly enhanced electric field along a cutting portion of the blade edge. The blade may have a uniform rate of erosion during use, so that both the conductive metal edge and the surrounding insulation layer erode at approximately the same rate. Also described are methods of fabricating insulated cutting electrodes, particularly blade electrodes.

Abstract translation: 本发明涉及电外科切割系统。 该系统包括导电叶片，其具有被绝缘体包围的非绝缘切割边缘。 脉冲电能源可以耦合到导电叶片，以沿叶片边缘的切割部分提供基本均匀且高度增强的电场。 刀片在使用过程中可能具有均匀的侵蚀速率，使得导电金属边缘和周围绝缘层两者以大致相同的速率腐蚀。 还描述了制造绝缘切割电极，特别是刀片电极的方法。

公开(公告)号：US20070059835A1

公开(公告)日：2007-03-15

申请号：US11505249

申请日：2006-08-15

Applicant: Thomas Chalberg ,  Mark Blumenkranz ,  Daniel Palanker ,  Alexander Vankov ,  Philip Hule ,  Michael Marmor ,  Michele Calos

Inventor： Thomas Chalberg ,  Mark Blumenkranz ,  Daniel Palanker ,  Alexander Vankov ,  Philip Hule ,  Michael Marmor ,  Michele Calos

IPC: C12N15/87

CPC classification number: C12N13/00 ,  A61K48/00 ,  C12N15/87

Abstract: The present invention provides a method of treating an ocular disease in a subject. In a first step, a nucleic acid is introduced into cells or a tissue. The nucleic acid is introduced by electron avalanche transfection. With this technique, a high electric field induces a vapor bubble and plasma discharge between an electrode and the surrounding medium. The formation of a vapor bubble generates mechanical stress. Plasma discharge through the ionized vapor in the bubble enables connectivity between the electrode and the surrounding medium, so that mechanical stress and electric field are applied simultaneously, which results in permeabilization of the cells or tissue. This permeabilization in turn allows the nucleic acid to enter the cell or tissue. Cells or tissue containing the nucleic acid are then transplanted into an ocular region of the subject.

Abstract translation: 本发明提供一种治疗受试者眼部疾病的方法。 在第一步骤中，将核酸引入细胞或组织。 通过电子雪崩转染引入核酸。 利用这种技术，高电场在电极和周围介质之间引起蒸汽气泡和等离子体放电。 气泡的形成产生机械应力。 通过气泡中的电离蒸汽的等离子体放电使得电极和周围介质之间能够连接，使得同时施加机械应力和电场，这导致细胞或组织的透化。 这种渗透反过来又允许核酸进入细胞或组织。 然后将含有核酸的细胞或组织移植到受试者的眼部区域。

公开(公告)号：US20070239260A1

公开(公告)日：2007-10-11

申请号：US11731644

申请日：2007-03-29

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61F2/06

CPC classification number: A61F2/82 ,  A61B18/14 ,  A61B2017/00504 ,  A61B2018/00619 ,  A61F2220/0008 ,  A61F2250/0001 ,  A61F2250/0069

Abstract: Tissue implants configured to adhere to biological tissues when activated by electrical energy may include an electrically conductive structure, a connector releasably connected to the electrically conductive structure, and a thermally crosslinkable coating covering at least the exposed portion of the electrically conductive structure. These tissue implants may be used for welding tissues to other tissues, or for welding tissue to the implant, and thus may be used to attach implants within a body, or for therapeutic uses. These implants may be used for wound closure or to create occlusions. Thermal damage to the tissue may be minimized by use of the thermally-crosslinkable material having a resistivity higher than that of the adjacent tissue.

Abstract translation: 构造成当由电能激活时被附着到生物组织上的组织植入物可以包括导电结构，可释放地连接到导电结构的连接器以及至少覆盖导电结构的暴露部分的热交联涂层。 这些组织植入物可用于将组织焊接到其他组织，或用于将组织焊接到植入物，并且因此可以用于将植入物附接到体内或用于治疗用途。 这些植入物可用于伤口闭合或产生闭塞。 通过使用具有比相邻组织的电阻率高的电阻率的热交联材料，可以使组织的热损伤最小化。

公开(公告)号：US20070239156A1

公开(公告)日：2007-10-11

申请号：US11726782

申请日：2007-03-22

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61B18/08

CPC classification number: A61B18/14 ,  A61B18/042 ,  A61B2018/00577 ,  A61B2018/00601 ,  A61B2018/00625 ,  A61B2018/1213 ,  A61B2018/122 ,  A61B2018/1472 ,  H05H1/48 ,  H05H2245/122

Abstract: An apparatus and method for cutting a material including conducting and non-conducting materials such as biological tissue, cellulose or plastic while the material is submerged in a conductive liquid medium. The apparatus has a cutting electrode with an elongate cutting portion having an aspect ratio (length to width) of 1 or more and a return electrode. The two electrodes are immersed in the conductive medium and a voltage is applied between them to heat the medium, thus producing a vapor cavity around the elongate cutting portion and ionizing a gas inside the vapor cavity to produce a plasma. The voltage applied between the electrodes is modulated in pulses having a modulation format selected to minimize the size of the vapor cavity, its rate of formation and heat diffusion into the material while the latter is cut with an edge of the elongate cutting portion. The modulation format includes pulses ranging in duration from 10 μs to 10 ms, as well as minipulses and micropulses, as necessary. The apparatus and method of invention allow the user to perform efficient thermal ablation and electrosurgical procedures in particular at power levels as low as 10 mW with minimal thermal and cavitation damage.

公开(公告)号：US20050090875A1

公开(公告)日：2005-04-28

申请号：US10939232

申请日：2004-09-09

Applicant: Daniel Palanker ,  Alexander Vankov

Inventor： Daniel Palanker ,  Alexander Vankov

IPC: A61F9/00 ,  G02B20060101

CPC classification number: A61N1/36046

Abstract: A system having a retinal prosthesis inside a mammalian eye and an external imaging unit outside the eye is provided. The external imaging unit includes an imager which receives an input optical image and a display which provides a processed optical image derived from the input optical image as an input to the eye. The external imaging unit also includes a tracking subsystem, to determine the position of the retinal prosthesis relative to the display. The external imaging unit includes an image processor, which performs spatial processing dependent on the position of the retinal prosthesis relative to the display. Thus the processed image provided to the eye is spatially processed according to the position of the retinal prosthesis. The image processor can perform other kinds of image processing as well (e.g., temporal image processing). An external imaging unit for use in such a system is also provided.

Abstract translation: 提供了一种在哺乳动物眼睛内部具​​有视网膜假体并且在眼睛外部具有外部成像单元的系统。 外部成像单元包括接收输入光学图像的成像器和从输入光学图像导出的经处理的光学图像作为眼睛的输入的显示器。 外部成像单元还包括跟踪子系统，用于确定视网膜假体相对于显示器的位置。 外部成像单元包括图像处理器，其根据视网膜假体相对于显示器的位置进行空间处理。 因此，根据视网膜假体的位置对提供给眼睛的经处理图像进行空间处理。 图像处理器也可以执行其他类型的图像处理（例如，时间图像处理）。 还提供了用于这种系统的外部成像单元。

公开(公告)号：US08591501B2

公开(公告)日：2013-11-26

申请号：US13042429

申请日：2011-03-07

Applicant: David Mintz ,  Daniel Palanker ,  Gregory Kintz

Inventor： David Mintz ,  Daniel Palanker ,  Gregory Kintz

IPC: A61F9/008 ,  A61B18/22 ,  G02B6/06

CPC classification number: A61F9/00802 ,  A61F9/00821 ,  A61F2009/00863 ,  A61F2009/00891

Abstract: Systems and processes are described relating to laser-based ophthalmic intervention technologies, and, more specifically, to techniques for creating lesions on an eye using a modular system featuring one or more coherent fiber bundles configured to deliver laser energy to the eye from a separate housing wherein a laser source is located. The subject technology may be utilized to not only separate a patient from certain portions of the hardware, but also to facilitate patterned lesion creation using mobile devices such as LIO and laser endoprobe devices.

Abstract translation: 描述了与基于激光的眼科干预技术相关的系统和过程，更具体地，涉及用于使用具有一个或多个相干光纤束的模块化系统来创建眼睛上的损伤的技术，其被配置为将激光能量从单独的壳体 其中定位有激光源。 主题技术可以用于不仅将患者与硬件的某些部分分开，而且还可以利用诸如LIO和激光内窥镜装置之类的移动装置来促进图案化损伤创建。