公开(公告)号：US20130026063A1

公开(公告)日：2013-01-31

申请号：US13561055

申请日：2012-07-29

申请人： Daniel B. Gillis ,  Robert Clarke ,  Joseph Woodson

发明人： Daniel B. Gillis ,  Robert Clarke ,  Joseph Woodson

IPC分类号： C10G53/04

CPC分类号： C10G21/003 ,  C10G1/08 ,  C10G45/00 ,  C10G67/16 ,  C10G2300/107 ,  C10G2300/206 ,  C10G2300/44

摘要： The invention is directed to a process that combines the solvent deasphalting with resin hydrotreatment so as to reduce the costs associated with performing each of the steps separately. The integrated process of the invention permits higher product yields coupled with lower energy and transportation costs.

摘要翻译： 本发明涉及一种将溶剂脱沥青与树脂加氢处理结合在一起的方法，以便降低与分别执行每个步骤相关的成本。 本发明的综合方法允许更高的产品产量以及更低的能量和运输成本。

公开(公告)号：US09932527B2

公开(公告)日：2018-04-03

申请号：US13561055

申请日：2012-07-29

申请人： Daniel B. Gillis ,  Robert Clarke ,  Joseph Woodson

发明人： Daniel B. Gillis ,  Robert Clarke ,  Joseph Woodson

IPC分类号： C10G21/00 ,  C10G45/00 ,  C10G67/16 ,  C10G1/08

CPC分类号： C10G21/003 ,  C10G1/08 ,  C10G45/00 ,  C10G67/16 ,  C10G2300/107 ,  C10G2300/206 ,  C10G2300/44

摘要： The invention is directed to a process that combines the solvent deasphalting with resin hydrotreatment so as to reduce the costs associated with performing each of the steps separately. The integrated process of the invention permits higher product yields coupled with lower energy and transportation costs.

公开(公告)号：US07297437B2

公开(公告)日：2007-11-20

申请号：US10483953

申请日：2002-02-12

申请人： Robert Clarke ,  Brian Dougherty ,  Stephen Harrison ,  J. Peter Millington ,  Samaresh Mohanta

发明人： Robert Clarke ,  Brian Dougherty ,  Stephen Harrison ,  J. Peter Millington ,  Samaresh Mohanta

IPC分类号： H01M4/36

CPC分类号： H01M6/182 ,  H01M6/22 ,  H01M2300/008 ,  H01M2300/0085 ,  H01M2300/0091

摘要： An electric device comprises a gelled acid electrolyte (142A) in complex with a lanthanide that forms a redox pair with a second element. Preferred electric devices include batteries and especially primary batteries, while preferred acid electrolytes (124A) have a sulfonic acid group. Contemplated lanthanides especially include cerium, and preferred second elements particularly include zinc. Alternatively, contemplated electric devices may comprise a gelled electrolyte (142A) in which with a lanthanide forms a redox pair with zinc.

摘要翻译： 电气装置包括与与第二元素形成氧化还原对的镧系元素复合的凝胶酸电解质（142A）。 优选的电气装置包括电池，特别是初级电池，而优选的酸性电解质（124A）具有磺酸基。 考虑的镧系元素特别包括铈，优选的第二元素尤其包括锌。 或者，预期的电气装置可以包括凝胶电解质（142A），其中镧系元素与锌形成氧化还原对。

公开(公告)号：US20050145743A1

公开(公告)日：2005-07-07

申请号：US11054026

申请日：2005-02-09

申请人： Robert Clarke ,  Thomas Neal

发明人： Robert Clarke ,  Thomas Neal

IPC分类号： D21F7/00 ,  B65H20/06 ,  D21G9/00 ,  B65H20/10

CPC分类号： B65H20/12 ,  B65H20/06 ,  B65H2301/511 ,  B65H2301/517 ,  B65H2301/522 ,  B65H2406/323 ,  B65H2801/84 ,  D21G9/0063

摘要： A system and method for transferring a continuously advancing paper web from a dryer to a reel section is provided. The system includes a first fabric defining a first moving conveyor. The first fabric may be a permeable fabric, which is positioned downstream from the dryer. A second fabric, which may also be permeable and defines a second moving conveyor, is also included. The first moving conveyor overlaps the second moving conveyor for a predetermined distance, and the first and second moving conveyors are configured to receive the paper web between the conveyors. A vacuum device is rotatably disposed against the first moving conveyor, and the dryer and the vacuum device are disposed relative to each other to form an open draw. The vacuum device is configured to produce a vacuum to attract the web to the first fabric for transferring the advancing web into the predetermined distance where the first and second conveyors overlap.

摘要翻译： 提供了一种用于将连续推进的纸幅从干燥器转移到卷轴部分的系统和方法。 该系统包括限定第一移动输送机的第一织物。 第一织物可以是位于干燥器下游的可渗透织物。 还可以包括也可渗透并限定第二移动输送机的第二织物。 第一移动输送机与第二移动输送机重叠预定距离，并且第一和第二移动输送机构造成在输送机之间接收纸幅。 真空装置可旋转地设置在第一移动输送机上，并且干燥器和真空装置相对于彼此设置以形成开放式抽出。 真空装置被配置为产生真空以将幅材吸引到第一织物，以将前进幅材传送到第一和第二输送机重叠的预定距离。

公开(公告)号：US5625767A

公开(公告)日：1997-04-29

申请号：US402839

申请日：1995-03-13

申请人： Brian Bartell ,  Robert Clarke

发明人： Brian Bartell ,  Robert Clarke

IPC分类号： G06F17/30 ,  G06T11/00

CPC分类号： G06F17/30572 ,  Y10S707/99935

摘要： A method and system for aiding users in visualizing the relatedness of retrieved text documents and the topics to which they relate comprises training a classifier by semantically analyzing an initial group of manually-classified documents, positioning the classes and documents in two-dimensional space in response to semantic associations between the classes, and displaying the classes and documents. The displayed documents may be retrieved by an information storage and retrieval subsystem in any suitable manner.

摘要翻译： 用于帮助用户可视化所检索的文本文档及其相关主题的相关性的方法和系统包括：通过语义分析手动分类文档的初始组来对分类器进行训练，将类和文档定位在二维空间中以作出响应 到类之间的语义关联，并显示类和文档。 显示的文件可以以任何合适的方式由信息存储和检索子系统检索。

公开(公告)号：US5549675A

公开(公告)日：1996-08-27

申请号：US180018

申请日：1994-01-11

申请人： Steven Neuenfeldt ,  James Brauker ,  Robert Clarke ,  Victoria Carr-Brendel

发明人： Steven Neuenfeldt ,  James Brauker ,  Robert Clarke ,  Victoria Carr-Brendel

IPC分类号： C12M1/00 ,  A61F2/02 ,  A61K9/00 ,  A61L27/00 ,  A61L27/38 ,  C12N5/06

CPC分类号： A61K9/0024 ,  A61F2/022 ,  A61L27/38 ,  Y10S623/902

摘要： A method for implanting cells into a host tissue is provided. The method comprises the steps of: creating an implant assembly for holding cells including wall means for forming a porous boundary between the host tissue and the implanted cells in the device, the pore size of the boundary being sufficient to isolate the implanted cells from the immune response; implanting the assembly without the cells into a host tissue; and accessing an interior of the assembly to add the cells thereto.

摘要翻译： 提供了将细胞植入宿主组织的方法。 该方法包括以下步骤：创建用于保持细胞的植入物组件，其包括用于在所述装置中的宿主组织和植入细胞之间形成多孔边界的壁装置，边界的孔径足以将植入的细胞与免疫 响应; 将没有细胞的组件植入宿主组织中; 以及访问组件的内部以将单元格添加到其中。

公开(公告)号：US20140088148A1

公开(公告)日：2014-03-27

申请号：US14009969

申请日：2012-04-04

申请人： Sivanesan Dakshanamurthy ,  Milton L. Brown ,  Robert Clarke ,  Ayesha N. Shahjahan ,  Jaqueline Smith

发明人： Sivanesan Dakshanamurthy ,  Milton L. Brown ,  Robert Clarke ,  Ayesha N. Shahjahan ,  Jaqueline Smith

IPC分类号： C07D213/32 ,  A61K31/4439 ,  A61K45/06 ,  C07D417/14 ,  C07D401/14 ,  C07D405/14 ,  A61K31/444 ,  C07D401/04 ,  C07D417/04

CPC分类号： A61K31/4439 ,  A61K31/41 ,  A61K31/426 ,  A61K31/427 ,  A61K31/444 ,  A61K45/06 ,  C07D213/32 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D417/04 ,  C07D417/14

摘要： Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

摘要翻译： 提供了通过IRE1剪接XBP1的小分子抑制剂，以及它们用于治疗或预防癌症（例如内分泌耐药性乳腺癌），糖尿病和肥胖症的方法。

公开(公告)号：US20070041912A1

公开(公告)日：2007-02-22

申请号：US10550471

申请日：2003-09-04

申请人： Elliot Ehrich ,  Daniel Deaver ,  Robert Clarke ,  Michael Lipp

发明人： Elliot Ehrich ,  Daniel Deaver ,  Robert Clarke ,  Michael Lipp

IPC分类号： A61K31/4747 ,  A61L9/04

CPC分类号： A61K9/0078 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/40 ,  A61K31/438 ,  A61K31/46 ,  A61K45/06

摘要： The invention relates to a method for treating a disease characterized by a constrictive airway comprising administering to a patient in need thereof via inhalation a pharmaceutical composition comprising trospium, wherein said patient achieves an effective therapy for at least 10 hours. The trospium composition is preferably a particulate formulation useful for administration via a dry powder inhaler. In a preferred embodiment, the composition further comprises a second active agent, such as a beta-2 agonist. A particularly preferred second active agent is formoterol, wherein the trospium, formoterol composition is manufactured by spray drying a mixture comprising trospium and formoterol.

摘要翻译： 本发明涉及用于治疗特征在于缩窄性气道的疾病的方法，其包括通过吸入给予有需要的患者包含trospium的药物组合物，其中所述患者达到有效治疗至少10小时。 ium组合物优选是可用于通过干粉吸入器施用的颗粒制剂。 在优选的实施方案中，组合物还包含第二活性剂，例如β-2激动剂。 特别优选的第二活性剂是福莫特罗，其中通过将包含trospium和福莫特罗的混合物喷雾干燥来制备tro石福莫特罗组合物。

公开(公告)号：US20060205112A1

公开(公告)日：2006-09-14

申请号：US11367725

申请日：2006-03-03

申请人： Martin Standing ,  Mark Pavier ,  Robert Clarke ,  Andrew Sawle ,  Kenneth McCartney

发明人： Martin Standing ,  Mark Pavier ,  Robert Clarke ,  Andrew Sawle ,  Kenneth McCartney

IPC分类号： H01L21/00

CPC分类号： H01L21/4825 ,  H01L21/4867 ,  H01L23/544 ,  H01L24/06 ,  H01L24/13 ,  H01L24/14 ,  H01L24/27 ,  H01L24/29 ,  H01L24/33 ,  H01L24/40 ,  H01L24/743 ,  H01L24/83 ,  H01L25/16 ,  H01L25/50 ,  H01L2223/54433 ,  H01L2223/54486 ,  H01L2224/0401 ,  H01L2224/05553 ,  H01L2224/05554 ,  H01L2224/0603 ,  H01L2224/13099 ,  H01L2224/16 ,  H01L2224/274 ,  H01L2224/29 ,  H01L2224/29101 ,  H01L2224/29111 ,  H01L2224/2919 ,  H01L2224/2929 ,  H01L2224/29339 ,  H01L2224/743 ,  H01L2224/83192 ,  H01L2224/83194 ,  H01L2224/838 ,  H01L2924/00013 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01015 ,  H01L2924/01022 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01042 ,  H01L2924/01046 ,  H01L2924/01047 ,  H01L2924/0105 ,  H01L2924/01075 ,  H01L2924/01078 ,  H01L2924/01079 ,  H01L2924/01082 ,  H01L2924/0133 ,  H01L2924/014 ,  H01L2924/0665 ,  H01L2924/0781 ,  H01L2924/1033 ,  H01L2924/1305 ,  H01L2924/13055 ,  H01L2924/13062 ,  H01L2924/13064 ,  H01L2924/13091 ,  H01L2924/14 ,  H01L2924/157 ,  H01L2924/19041 ,  H01L2924/19042 ,  H01L2924/19043 ,  H05K1/0266 ,  H05K3/1241 ,  H05K3/245 ,  H01L2924/00 ,  H01L2924/00014 ,  H01L2224/29099

摘要： A semiconductor package fabrication method in which drop on demand deposition of a drop on demand depositable material is used to prepare one component or a plurality of components of a semiconductor package or multi-chip module.

摘要翻译： 一种半导体封装制造方法，其中使用按需存放材料的按需投入沉积来制备半导体封装或多芯片模块的一个组件或多个组件。

公开(公告)号：US20060201648A1

公开(公告)日：2006-09-14

申请号：US11417848

申请日：2006-05-04

申请人： Robert Clarke ,  Thomas Neal

发明人： Robert Clarke ,  Thomas Neal

IPC分类号： D21F7/00

CPC分类号： B65H20/12 ,  B65H20/06 ,  B65H2301/511 ,  B65H2301/517 ,  B65H2301/522 ,  B65H2406/323 ,  B65H2801/84 ,  D21G9/0063

摘要： A system and method for transferring a continuously advancing paper web from a dryer to a reel section is provided. The system includes a first fabric defining a first moving conveyor. The first fabric may be a permeable fabric, which is positioned downstream from the dryer. A second fabric, which may also be permeable and defines a second moving conveyor, is also included. The first moving conveyor overlaps the second moving conveyor for a predetermined distance, and the first and second moving conveyors are configured to receive the paper web between the conveyors. A vacuum device is rotatably disposed against the first moving conveyor, and the dryer and the vacuum device are disposed relative to each other to form an open draw. The vacuum device is configured to produce a vacuum to attract the web to the first fabric for transferring the advancing web into the predetermined distance where the first and second conveyors overlap.