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1.发明授权公开(公告)号：US06458763B1
公开(公告)日：2002-10-01
申请号：US09398330
申请日：1999-09-17
IPC分类号： A61K3800
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/604 , Y10S514/964
摘要： The present invention is directed to bioactive compositions that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of compositions comprising an effective amount of bone sialoprotein to enhance the repair of damaged or diseased bone.
摘要翻译： 本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。 更具体地，本发明涉及使用包含有效量的骨唾液酸蛋白的组合物来增强受损或患病骨的修复。
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公开(公告)号：US07122205B2
公开(公告)日：2006-10-17
申请号：US10811649
申请日：2004-03-29
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K47/34
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
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公开(公告)号：US06733787B2
公开(公告)日：2004-05-11
申请号：US09956390
申请日：2001-09-19
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61K910
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Methods for tissue repair are provided employing a matrix comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa and applying the matrix to a tissue defect. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译： 提供了使用包含生物相容的生物侵蚀性聚合物的基质的组织修复方法，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶性为约0.01 在约25℃下为约500mg / mL，粘合强度为约600至约150,000Pa，并将基质施加于组织缺损。 基质或粘合剂可进一步包含填料或生物活性剂，或两者。
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4.发明授权公开(公告)号：US06303138B1
公开(公告)日：2001-10-16
申请号：US09398494
申请日：1999-09-17
IPC分类号： A61F200
CPC分类号： A61L27/227 , A61L27/54 , A61L2300/236 , A61L2300/252 , A61L2300/414 , A61L2300/604
摘要： The present invention is directed to bioactive composition that induce the repair of damaged or diseased connective tissues upon contact of the damaged or diseased tissues with the composition in vivo. More particularly the present invention is directed to the use of a composition comprising an effective amount of endothelin to enhance the repair of damaged or diseased bone and cartilage tissues.
摘要翻译： 本发明涉及在损伤或患病组织与体内组合物接触时诱导损伤或患病结缔组织修复的生物活性组合物。 更具体地，本发明涉及包含有效量的内皮素的组合物的用途，以增强受损或患病的骨和软骨组织的修复。
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5.发明授权Isolation of precursor cells from hematopoietic and nonhematopoietic tissues and their use in vivo bone and cartilage regeneration 失效从造血和非造血组织分离前体细胞及其在体内骨和软骨再生中的应用公开(公告)号：US06200606B1
公开(公告)日：2001-03-13
申请号：US08891952
申请日：1997-07-14
IPC分类号： A61K3512
CPC分类号： C12N5/0667 , A61K35/12 , A61K38/00 , A61K2035/124 , A61L27/3817 , A61L27/3821 , A61L27/3839 , A61L27/3847 , A61L27/3852 , C12N5/0663 , C12N2500/38 , C12N2501/39 , C12N2501/91
摘要： The present invention relates to the isolation of cartilage or bone precursor cells from hematopoietic and non-hematopoietic cells and their use in bone and cartilage regeneration procedures. The precursor cells are used for in vivo bone or cartilage repair by transplanting the cells, with or without a carrier material and without the need for in vitro culturing of the cells, to sites in the body requiring bone or cartilage repair.
摘要翻译： 本发明涉及从造血细胞和非造血细胞中分离软骨或骨前体细胞及其在骨和软骨再生过程中的用途。 前体细胞用于体内骨或软骨修复，通过移植具有或不具有载体材料的细胞，并且不需要体外培养细胞到体内需要骨或软骨修复的部位。
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公开(公告)号：US5733868A
公开(公告)日：1998-03-31
申请号：US633118
申请日：1996-04-16
申请人： Dale R. Peterson , Samuel I. Stupp
发明人： Dale R. Peterson , Samuel I. Stupp
IPC分类号： A61L24/00 , A61L24/04 , A61L24/10 , C09J177/04 , C09J189/00 , A61B17/08 , C09J201/00 , A61K37/02
CPC分类号： C09J189/00 , A61L24/043 , A61L24/106
摘要： A composition and method for repairing damaged connective tissue is provided. The composition comprises pseudo-poly(amino acids) and/or classic poly(amino acids) that exhibit adhesiveness for connective tissues. The composition is formed into an adhesive tissue repair implant and pressed against the damaged tissue to adhere the adhesive composition to the tissue.
摘要翻译： 提供了修复损伤的结缔组织的组合物和方法。 该组合物包含对结缔组织显示粘附性的假聚（氨基酸）和/或经典聚（氨基酸）。 将组合物形成为粘合剂组织修复植入物并压靠损伤的组织以将粘合剂组合物粘附到组织上。
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公开(公告)号：US5730933A
公开(公告)日：1998-03-24
申请号：US633032
申请日：1996-04-16
申请人： Dale R. Peterson
发明人： Dale R. Peterson
CPC分类号： A61L2/0011 , A61L2/0035
摘要： The present invention relates to a composition and method that optimizes retention of physiological activity of a biologically active compound during sterilization of said compound with gamma or electron-beam radiation. The method comprises the steps of forming a protected mixture that comprises the biologically active compound, an extraneous protein, and a free-radical scavenger, and irradiating the protected mixture with about 1 to about 3 mRad of gamma or electron-beam radiation.
摘要翻译： 本发明涉及在用γ射线或电子束辐射灭菌所述化合物的过程中优化生物活性化合物的生理活性的保留的组合物和方法。 该方法包括以下步骤：形成包含生物活性化合物，外来蛋白质和自由基清除剂的受保护的混合物，并用约1至约3mRad的γ射线或电子束辐射照射被保护的混合物。
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公开(公告)号：US20120239145A1
公开(公告)日：2012-09-20
申请号：US13230623
申请日：2011-09-12
申请人： Dale R. Peterson , Peter Popper , Justin C. Anderson , Kevin Ohashi , Ralph Mattern , Jamal Rushdy
发明人： Dale R. Peterson , Peter Popper , Justin C. Anderson , Kevin Ohashi , Ralph Mattern , Jamal Rushdy
IPC分类号： A61F2/08
CPC分类号： A61F2/08 , A61F2/0063
摘要： This reinforcing band (1) for restoring a soft tissue, such as a tendon or a ligament, comprises a textile component with at least one free edge (2, 4). In addition, the or each free edge is folded back into an inner volume of the textile component in such a way as to define an attachment edge (6, 8) suitable for attachment to the soft tissue.
摘要翻译： 用于恢复诸如腱或韧带的软组织的该加强带（1）包括具有至少一个自由边缘（2,4）的织物部件。 此外，该或每个自由边缘以这样的方式折回到纺织部件的内部容积中，以便限定适合于附接到软组织的附接边缘（6,8）。
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公开(公告)号：US06923985B2
公开(公告)日：2005-08-02
申请号：US09923118
申请日：2001-08-06
申请人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
发明人： Dale R. Peterson , Z. David Deng , Todd P. Glancy
IPC分类号： A61L27/00 , A61K9/20 , A61L24/00 , A61L24/04 , A61L27/04 , A61L27/18 , A61L27/46 , C09J9/00 , A61K9/10 , A61K47/34 , A61K31/765 , C08G63/08
CPC分类号： A61L27/18 , A61K9/204 , A61L24/0073 , A61L24/0084 , A61L24/046 , A61L27/04 , A61L27/46 , C08L67/04 , Y10S528/931
摘要： Improved matrices and adhesives for tissue repair comprising a biocompatible, bioerodable polymer, said polymer comprising a thermoplastic lactide-containing terpolymer of monomer units derived from lactic acid, glycolic acid, and either caprolactone or valerolactone, which has a water solubility of about 0.01 to about 500 mg/mL at about 25° C. and adhesive strength of about 600 to about 150,000 Pa. The matrix or adhesive can further comprise a filler or a bioactive agent, or both.
摘要翻译： 用于组织修复的改进的基质和粘合剂，其包含生物相容的可生物侵蚀的聚合物，所述聚合物包含衍生自乳酸，乙醇酸和己内酯或戊内酯的单体单元的热塑性丙交酯三元共聚物，其水溶解度为约0.01至约 在约25℃下为500mg / mL，粘合强度为约600至约150,000Pa。基质或粘合剂可进一步包含填料或生物活性剂，或两者。
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公开(公告)号：US06326025B1
公开(公告)日：2001-12-04
申请号：US09530172
申请日：2000-04-24
IPC分类号： A61F1302
CPC分类号： A61L24/04 , C08L101/02 , Y10S602/904
摘要： The present invention is directed to a biocompatible tissue reactive composition comprising a functionalized polymer having tissue reactive substituents that are capable of forming covalent bonds with tissue associated functional groups.
摘要翻译： 本发明涉及生物相容性组织反应性组合物，其包含具有能与组织相关官能团形成共价键的组织反应性取代基的官能化聚合物。
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