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1.发明公开公开(公告)号：US20240318210A1
公开(公告)日：2024-09-26
申请号：US18492080
申请日：2023-10-23
申请人： Conagen Inc.
发明人： Haiyun Pan , Hui Chen , Oliver Yu , Xiaoran Fu
CPC分类号： C12P17/06 , C12N9/0071 , C12Y114/14001
摘要： The present disclosure relates, at least in part, to the production of delta-lactones from fatty acid substrates via a batch fermentation method in an engineered microbe using a recombinant cytochrome P450 monooxygenase.
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公开(公告)号：US20240301462A1
公开(公告)日：2024-09-12
申请号：US18483622
申请日：2023-10-10
申请人： Conagen Inc.
发明人： Guohong Mao , Albertus Jan Vermeulen , Shi Sun , Oliver Yu
摘要： The present invention relates to novel steviol glycosides rebaudioside R6-5, rebaudioside R6-6, and rebaudioside R7-5 and the production of these novel steviol glycosides, such as through enzymatic bioconversion.
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公开(公告)号：US20240093255A1
公开(公告)日：2024-03-21
申请号：US18170576
申请日：2023-02-17
申请人： Conagen Inc.
发明人： Guohong Mao , Meaghan Valliere , Johnson Wu , Oliver Yu , Sean Robert Johnson
CPC分类号： C12P19/18 , C12N9/1051 , C12N9/88 , C12P19/04 , C12Y204/01047 , C12Y204/01069
摘要： The present invention provides a novel biosynthetic production process which converts L-galactose into 2′-fucosyllactose via four enzymatically catalyzed reaction steps. The present process is designed such that co-factors required by the process are regenerated within the four reaction steps, hence making the process cost-effective and efficient. The process can be performed in vitro in a cell-free system. The present invention also provides mutant enzymes that can be used to increase production levels of 2′-fucosyllactose, whether using the novel pathway described herein or the mannose-dependent pathway known in the art.
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公开(公告)号：US11549131B2
公开(公告)日：2023-01-10
申请号：US17150774
申请日：2021-01-15
申请人： Conagen Inc.
摘要： Provided herein are methods for making gamma lactones comprising reacting a carboxylic acid substrate with a heterologous cytochrome P450 (CYP450) protein with carboxylic acid 4-hydroxylase activity.
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公开(公告)号：US20220112526A1
公开(公告)日：2022-04-14
申请号：US17514050
申请日：2021-10-29
申请人： Conagen Inc.
发明人： Rui Zhou , Junying Ma , Oliver Yu
IPC分类号： C12P7/24 , C11B9/00 , A23L33/105 , C12N9/02
摘要： The present invention relates to the production of vanillin via the bioconversion of isoeugenol. The bioconversion can be mediated in a cellular system (e.g., an Escherichia coli bacterium), or in an enzymatic reaction mixture without a cellular system.
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公开(公告)号：US20210381019A1
公开(公告)日：2021-12-09
申请号：US17345034
申请日：2021-06-11
申请人： Conagen Inc.
发明人： Guohong Mao , Michael Batten , Yang Luo , Oliver Yu
摘要： The present invention relates to novel steviol glycosides R6-1, R6-2A, R6-2B, R6-4A, R6-4B and R7-2 and the production of these novel steviol glycosides, such as through enzymatic bioconversion. The use of these novel steviol glycosides as sweeteners and in orally consumable products are also provided.
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公开(公告)号：US20230313254A1
公开(公告)日：2023-10-05
申请号：US18054195
申请日：2022-11-10
申请人： Conagen Inc.
发明人： Guohong Mao , Michael Batten , Oliver Yu , Timothy Joseph Hanly , Phillip James Hunt , Hongfang Liu , Yang Luo
CPC分类号： C12P19/24 , C12N9/90 , C12N15/70 , C12N15/81 , C12Y501/03 , C12R2001/19
摘要： Provided herein are methods for identifying and isolating polynucleotides coding for polypeptides having D-allulose 3-epimerase activity from a wide variety of microorganisms. Also provided are nucleic acid constructs, vectors and recombinant host cells comprising the polynucleotides coding for D-allulose 3-epimerase activity as well as methods for producing allulose from fructose using said recombinant host cells having D-allulose 3-epimerase activity or the D-allulose 3-epimerase enzyme of said recombinant host cells having D-allulose 3-epimerase activity.
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公开(公告)号：US20220325313A1
公开(公告)日：2022-10-13
申请号：US17712452
申请日：2022-04-04
申请人： Conagen Inc.
发明人： Yisheng Wu , Wanli Lu , Jacob Thomas Courtney , David Nunn , Oliver Yu
摘要： Provided herein are recombinant nucleic acid molecules, nucleic acid constructs, fusion enzymes, transformed host cells, and methods for making aroma compounds alpha-ionone or beta-ionone.
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公开(公告)号：US20220112525A1
公开(公告)日：2022-04-14
申请号：US17514043
申请日：2021-10-29
申请人： Conagen Inc.
发明人： Rui Zhou , Junying Ma , Oliver Yu
IPC分类号： C12P7/24 , C11B9/00 , A23L33/105 , C12N9/02
摘要： The present invention relates to the production of vanillin via the bioconversion of isoeugenol. The bioconversion can be mediated in a cellular system (e.g., an Escherichia coli bacterium), or in an enzymatic reaction mixture without a cellular system.
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公开(公告)号：US20210261991A1
公开(公告)日：2021-08-26
申请号：US17150774
申请日：2021-01-15
申请人： Conagen Inc.
摘要： Provided herein are methods for making gamma lactones comprising reacting a carboxylic acid substrate with a heterologous cytochrome P450 (CYP450) protein with carboxylic acid 4-hydroxylase activity.
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