公开(公告)号：US07038040B2

公开(公告)日：2006-05-02

申请号：US10608101

申请日：2003-06-27

Applicant: John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

Inventor： John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

IPC: C07J71/00 ,  C07D301/14

CPC classification number: C07J71/00 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J53/00 ,  C07J53/002 ,  C07J71/0015 ,  C12P33/005 ,  C12P33/10 ,  C12Q1/02

Abstract: Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group —CHR4—CHR5— or CR4═CR5— R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, -B-B- represents the group —CHR6—CHR7— or an alpha- or beta-oriented group:  where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.

Abstract translation: 提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦克风和其它式I化合物，其中：-AA-代表基团-CHR 4 -CHR 5， SUP> - 或CR 4 -CR 5 - R 3，R 4和R 5， 低级烷基，低级烷氧基，羟基烷基，烷氧基烷基，羟基羰基，氰基，芳氧基，R 1表示α取代的低级烷氧基羰基或 羟基烷基，-BB-表示基团-CHR 6 -CHR 7 - 或α或β取代基团：其中R 6为 - R 7和R 7独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基和R 8， / O 2和R 9独立地选自氢，卤素， 低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基或R 8和R 9一起包含碳环或杂环结构， 或R 9或R 9与R 6或R 7连接的碳环或杂环结构包括与 五环D环。

公开(公告)号：US20050263213A1

公开(公告)日：2005-12-01

申请号：US11053450

申请日：2005-02-08

Applicant: Chin Liu

Inventor： Chin Liu

IPC: A01D34/00 ,  B27C1/14 ,  B27G13/04

CPC classification number: B27G13/04 ,  Y10T83/9464 ,  Y10T407/1936

Abstract: A rotary cutter includes: an elongated shaft that defines a rotation axis and that has two opposite mounting ends, and at least one axially extending blade-mounting surface parallel to the rotation axis and extending between the mounting ends; a pair of blade-aligning members, each of which is mounted on a respective one of the mounting ends of the shaft, and each of which is formed with at least one protrusion; at least one blade attached to the blade-mounting surface and having two opposite end portions, each of which is formed with a recess that receives the protrusion of a respective one of the blade-aligning members; and a fastening plate and screws for fastening the blade to the shaft.

Abstract translation: 旋转切割器包括：细长轴，其限定旋转轴线并且具有两个相对的安装端，以及平行于旋转轴线并在安装端之间延伸的至少一个轴向延伸的叶片安装表面; 一对刀片对准构件，每个构件安装在所述轴的相应一个安装端上，并且每个都形成有至少一个突起; 至少一个叶片附接到叶片安装表面并且具有两个相对的端部部分，每个叶片形成有凹部，该凹部容纳相应的叶片对齐部件的突出部; 以及用于将叶片紧固到轴上的紧固板和螺钉。

公开(公告)号：US06953851B2

公开(公告)日：2005-10-11

申请号：US10672680

申请日：2003-09-26

Applicant: John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

Inventor： John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

IPC: A61K31/58 ,  C07J19/00 ,  C07J21/00 ,  C07J31/00 ,  C07J53/00 ,  C07J71/00 ,  C12P33/00 ,  C12P33/10 ,  C12Q1/02

CPC classification number: C07J71/00 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J53/00 ,  C07J53/002 ,  C07J71/0015 ,  C12P33/005 ,  C12P33/10 ,  C12Q1/02

Abstract: Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: —A—A—, —B—B—, R1, R3, R8 and R9 are as defined in the specification.

Abstract translation: 提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦克风和其它式I化合物，其中：-AA-，-BB-，R 1，R 3， / SUP>，R 8和R 9如说明书中所定义。

公开(公告)号：US20050213984A1

公开(公告)日：2005-09-29

申请号：US10807201

申请日：2004-03-24

Applicant: Chin Liu

Inventor： Chin Liu

IPC: H04B10/00 ,  H04B10/24

CPC classification number: H04B10/40

Abstract: A duplex optical transceiver comprises a connector for optical cable with an optical cable lengthwise disposed therein, a ring-shaped clinging member formed of metal a hollow, cylindrical body formed of plastic, the body including a first opening at an open end coupled to a light source, a second opening on the peripheral surface coupled to a sensor, and a recessed, annular shoulder at the other end, and a filter mirror disposed within the body for deflecting light emitted by the light source to an optical fiber of the optical cable and reflecting light incident onto the optical fiber to the sensor. The clinging member is insertable into the shoulder for fastening by snapping.

Abstract translation: 双工光收发器包括用于光缆的连接器，其中纵向设置有光缆，由金属形成的环形保持构件，由塑料形成的中空圆柱形本体，该主体包括与光连接的开放端的第一开口 源，耦合到传感器的外围表面上的第二开口和另一端的凹入的环形肩部，以及设置在主体内的滤光镜，用于将由光源发射的光偏转到光缆的光纤， 将入射到光纤上的光反射到传感器。 附着构件可插入肩部，用于通过卡扣紧固。

公开(公告)号：US5648511A

公开(公告)日：1997-07-15

申请号：US452187

申请日：1995-05-25

Applicant: John S. Ng ,  Claire A. Przybyla ,  Richard A. Mueller ,  Michael L. Vazquez ,  Daniel P. Getman ,  John J. Freskos ,  Gary A. DeCrescenzo ,  Deborah E. Bertenshaw ,  Robert M. Heintz ,  Suhong Zhang ,  Chin Liu ,  Scott A. Laneman

Inventor： John S. Ng ,  Claire A. Przybyla ,  Richard A. Mueller ,  Michael L. Vazquez ,  Daniel P. Getman ,  John J. Freskos ,  Gary A. DeCrescenzo ,  Deborah E. Bertenshaw ,  Robert M. Heintz ,  Suhong Zhang ,  Chin Liu ,  Scott A. Laneman

IPC: A61K31/17 ,  A61K31/195 ,  A61K31/197 ,  A61K31/27 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61K38/00 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C215/28 ,  C07C269/04 ,  C07C269/06 ,  C07C271/16 ,  C07F7/18 ,  C07K5/078 ,  C07D253/00

CPC classification number: C07C269/06 ,  A61K31/17 ,  A61K31/195 ,  A61K31/197 ,  A61K31/27 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  C07C213/00 ,  C07C213/02 ,  C07C213/08 ,  C07C269/04 ,  C07F7/188 ,  C07K5/06139 ,  A61K38/00 ,  C07B2200/07

Abstract: A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.

Abstract translation: 对于易于大规模制备基于羟基脲的手性HIV蛋白酶抑制剂的中间体描述了合成。 该方法包括由手性α氨基醛形成非对映选择性环氧化物或羟腈。

公开(公告)号：US07129345B2

公开(公告)日：2006-10-31

申请号：US11156418

申请日：2005-06-20

Applicant: John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

Inventor： John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

IPC: C07J21/00 ,  C07J71/00

CPC classification number: C07J71/00 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J53/00 ,  C07J53/002 ,  C07J71/0015 ,  C12P33/005 ,  C12P33/10 ,  C12Q1/02

Abstract: Multiple novel keto-substituted intermediates are provided for the synthesis of epoxymexrenone, useful as an Aldosterone Receptor Antagonist.

Abstract translation: 提供了多种新的酮取代的中间体用于合成环氧麦芽糖酮，可用作醛固酮受体拮抗剂。

公开(公告)号：US07112669B2

公开(公告)日：2006-09-26

申请号：US11052549

申请日：2005-02-07

Applicant: John S. Ng ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Joseph J. Wieczorek ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Ping T. Wang ,  Edward E. Yonan ,  Richard M. Weier ,  Thomas R. Kowar ,  Julio A. Baez ,  Bernhard Erb

Inventor： John S. Ng ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Joseph J. Wieczorek ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Ping T. Wang ,  Edward E. Yonan ,  Richard M. Weier ,  Thomas R. Kowar ,  Julio A. Baez ,  Bernhard Erb

IPC: C07J21/00 ,  C07J71/00

CPC classification number: C07J71/00 ,  C07D301/12 ,  C07J1/0059 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J41/0094 ,  C07J53/002 ,  C07J71/0005 ,  C07J71/0015 ,  C07J75/00 ,  C12P33/005 ,  C12P33/10

Abstract: Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Abstract translation: 公开了制备9,11-环氧类固醇的中间体。 特别公开的是11,12-环氧类固醇，4,5-9,11-二环氧类固醇和12-酮类固醇中间体。

公开(公告)号：US20050256094A1

公开(公告)日：2005-11-17

申请号：US11052549

申请日：2005-02-07

Applicant: John Ng ,  Chin Liu ,  Dennis Anderson ,  Jon Lawson ,  Joseph Wieczorek ,  Sastry Kunda ,  Leo Letendre ,  Mark Pozzo ,  Yuen-Lung Sing ,  Ping Wang ,  Edward Yonan ,  Richard Weir ,  Thomas Kowar ,  Julio Baez ,  Bernhard Erb

Inventor： John Ng ,  Chin Liu ,  Dennis Anderson ,  Jon Lawson ,  Joseph Wieczorek ,  Sastry Kunda ,  Leo Letendre ,  Mark Pozzo ,  Yuen-Lung Sing ,  Ping Wang ,  Edward Yonan ,  Richard Weir ,  Thomas Kowar ,  Julio Baez ,  Bernhard Erb

IPC: A61K31/58 ,  C07D301/12 ,  C07J1/00 ,  C07J21/00 ,  C07J31/00 ,  C07J41/00 ,  C07J53/00 ,  C07J71/00 ,  C12P33/00 ,  C12P33/10

CPC classification number: C07J71/00 ,  C07D301/12 ,  C07J1/0059 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J41/0094 ,  C07J53/002 ,  C07J71/0005 ,  C07J71/0015 ,  C07J75/00 ,  C12P33/005 ,  C12P33/10

Abstract: Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.

Abstract translation: 公开了制备9,11-环氧类固醇的中间体。 特别公开的是11,12-环氧类固醇，4,5-9,11-二环氧类固醇和12-酮类固醇中间体。

公开(公告)号：US06586591B2

公开(公告)日：2003-07-01

申请号：US09943117

申请日：2001-08-31

Applicant: John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

Inventor： John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

IPC: C07J2100

CPC classification number: C07J71/00 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J53/00 ,  C07J53/002 ,  C07J71/0015 ,  C12P33/005 ,  C12P33/10 ,  C12Q1/02

Abstract: A process for the formation of compounds of Formula VI: comprising hydrolyzing a compound corresponding to Formula VII: wherein —A—A—, —B—B—, R3, R8 and R9 are as defined in the specification.

Abstract translation: 形成式VI化合物的方法：包括水解对应于式VII的化合物：其中-A-A-，-B-B-，R3，R8和R9如说明书中所定义。

公开(公告)号：US06180780B2

公开(公告)日：2001-01-30

申请号：US09246908

申请日：1999-02-09

Applicant: John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

Inventor： John S. Ng ,  Ping T. Wang ,  Julio A. Baez ,  Chin Liu ,  Dennis K. Anderson ,  Jon P. Lawson ,  Bernhard Erb ,  Joseph Wieczorek ,  Gennaro Mucciariello ,  Fortunato Vanzanella ,  Sastry A. Kunda ,  Leo J. Letendre ,  Mark J. Pozzo ,  Yuen-Lung L. Sing ,  Edward E. Yonan

IPC: C07J2100

CPC classification number: C07J71/00 ,  C07J21/00 ,  C07J21/003 ,  C07J31/006 ,  C07J53/00 ,  C07J53/002 ,  C07J71/0015 ,  C12P33/005 ,  C12P33/10 ,  C12Q1/02

Abstract: Multiple reaction schemes, process steps and intermediates are provided for the synthesis of epoxymexrenone, useful as a diuretic, and other compounds of Formula I wherein the variables are as defined by the specification.

Abstract translation: 提供了多种反应方案，方法步骤和中间体，用于合成环氧麦芽糖酮，其可用作利尿剂，和其它式I化合物，其中变量如本说明书所定义。