专利检索 ap:"Sastry Kunda" 第 1 页

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发明申请
PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN 审中-公开
标题翻译：制备9,11环氧甾体的方法及其有用的中间体

公开(公告)号：US20070060746A1

公开(公告)日：2007-03-15

申请号：US11459040

申请日：2006-07-21

申请人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan

发明人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan

IPC分类号： C07J71/00 , C07J53/00

CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02

摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group —CHR4—CHR5— or —CR4═CR5— —R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.

摘要翻译： 提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦克风和其它式I化合物，其中：-AA-代表基团-CHR 4 -CHR 5， SUP→ - 或-CR 4 -CR 5 - -R 3，R 4和R 4 - 5个独立地选自氢，卤素，羟基，低级烷基，低级烷氧基，羟基烷基，烷氧基烷基，羟基羰基，氰基，芳氧基，R 1表示α取向的低级烷氧基羰基或羟烷基，-BB-代表基团-CHR 6 -CHR 7 - 或α或β取代基团：其中R 6， SO 2和R 7独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基和R 8和R 9独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基或R 8和R 9共同构成碳环或杂环结构或R 9或R 9与R 6或R 7连同包含碳环或杂环结构稠合到五环D环。