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1.发明授权Films having improved characteristics and methods for their preparation and use 失效具有改进特性的薄膜及其制备和使用方法
公开(公告)号：US5931165A
公开(公告)日：1999-08-03
申请号：US795744
申请日：1997-02-06
申请人： Cary J. Reich , Donald G. Wallace , Greg Dapper
发明人： Cary J. Reich , Donald G. Wallace , Greg Dapper
IPC分类号： A61B17/00 , A61B17/072 , A61B17/11 , A61B18/00 , A61B19/00 , A61L15/32 , A61L24/10 , A61L31/04 , A61L31/06 , A61L31/14
CPC分类号： A61L31/148 , A61B17/00491 , A61B17/11 , A61L15/32 , A61L15/325 , A61L24/104 , A61L31/042 , A61L31/043 , A61L31/045 , A61L31/06 , A61L31/141 , A61B17/07292 , A61B18/042 , A61B2017/00504 , A61B2090/0816
摘要： Gelatin film compositions are useful for immobilization over tissue, usually by the application of energy to the films. Exemplary films comprise cross-linked and non-cross-linked granular and non-granular gelatin sheets, typically including a plasticizer. The gelatin films are dry, thin, and preferably meet certain pliability, elasticity, melting temperature, and other criteria. Methods are described for producing these films from collagen. Methods are further described for applying these films to tissue.
摘要翻译： 明胶膜组合物可用于固定在组织上，通常通过向膜施加能量。 示例性膜包括交联和非交联的颗粒状和非颗粒状明胶片，通常包括增塑剂。 明胶膜干燥，薄，并且优选满足一定的柔韧性，弹性，熔融温度和其它标准。 描述了从胶原制备这些膜的方法。 进一步描述了将这些膜应用于组织的方法。
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公开(公告)号：US5791352A
公开(公告)日：1998-08-11
申请号：US758267
申请日：1996-11-08
申请人： Cary J. Reich , Donald Wallace , Greg Dapper
发明人： Cary J. Reich , Donald Wallace , Greg Dapper
CPC分类号： A61L31/148 , A61L31/042 , A61L31/043 , A61L31/06 , A61L31/141 , A61B2090/0816 , Y10S602/904
摘要： Tissue adhesions are inhibited by applying and immobilizing a solid preformed matrix material over a target region, such as a surgical site, in a first tissue surface. The matrix material may be any continuous solid material, such as a sheet or film. After applying the material to the target region, the material is immobilized by applying energy over at least a portion of the surface of the matrix material which causes the material to fuse to the underlying tissue. The matrix material is preferably bioabsorbable so that it is resorbed by the body over time. Suitable matrix materials include proteins, polysaccharrides, and synthetic polymers.
摘要翻译： 通过在第一组织表面中将固体预成型基质材料施加并固定在目标区域（例如外科手术部位）上来抑制组织粘连。 基质材料可以是任何连续的固体材料，例如片材或薄膜。 在将材料施加到目标区域之后，通过在基体材料的表面的至少一部分上施加能量来固定材料，这导致材料熔化到下面的组织。 基质材料优选是生物可吸收的，使得其随着时间被身体吸收。 合适的基质材料包括蛋白质，多糖和合成聚合物。
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公开(公告)号：US20110223231A1
公开(公告)日：2011-09-15
申请号：US13114784
申请日：2011-05-24
IPC分类号： A61M5/178
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US08303981B2
公开(公告)日：2012-11-06
申请号：US13174963
申请日：2011-07-01
申请人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
发明人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
CPC分类号： A61K38/4833 , A61K9/0002 , A61L2/081 , A61L2/087 , A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , A61L2400/04
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US07871637B2
公开(公告)日：2011-01-18
申请号：US11859312
申请日：2007-09-21
申请人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
发明人： Zhen Qian , A. Edward Osawa , Cary J. Reich , Donald G. Wallace , Narinder S. Shargill , Felix Vega
CPC分类号： A61L24/0031 , A61L24/043 , A61L24/104 , A61L2400/04 , C08L89/00
摘要： Dry cross-linked gelatin compositions are prepared that rapidly re-hydrate to produce gelatin hydrogels suitable as hemostatic sealants. Gelatin is cross-linked in the presence of certain re-hydration aids, such as polyethylene glycol, polyvinylprovidone, and dextran, in order to produce a dry cross-linked gelatin powder. The use of the re-hydration aids has been found to substantially increase the re-hydration rate in the presence of an aqueous re-hydration medium, typically thrombin-containing saline.
摘要翻译： 制备干燥的交联明胶组合物，其快速再水化以产生适合作为止血密封剂的明胶水凝胶。 在某些再水化助剂如聚乙二醇，聚乙烯基丙基吡咯烷酮和葡聚糖存在下，明胶是交联的，以产生干燥的交联明胶粉末。 已经发现使用再水合助剂在含水的再水合介质（通常为含有凝血酶的盐水）的存在下显着增加再水合速率。
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公开(公告)号：US6063061A
公开(公告)日：2000-05-16
申请号：US903674
申请日：1997-07-31
IPC分类号： A61K47/42 , A01K1/015 , A61F2/00 , A61K9/00 , A61L20060101 , A61L24/00 , A61L27/00 , A61L27/52 , A61L27/54 , A61L31/00 , A61L31/14 , A61L31/16 , A61M5/00 , A61P17/02 , A61P41/00 , C08J3/075 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/00 , C08L101/00 , C08L101/16
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418
摘要： Molecular cross-linked gels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such molecular gels may be applied to target sites in a patient's body by extruding the gel through an orifice at the target site. Alternatively, the gels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 分子交联凝胶包含多种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种分子凝胶可以通过在目标部位的孔口挤出凝胶而施加到患者体内的靶位点。 或者，凝胶可能被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于抑制手术后脊柱和其他组织粘连，用于填充组织斑点，组织束，体腔，手术缺陷等。
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公开(公告)号：US08357378B2
公开(公告)日：2013-01-22
申请号：US13114784
申请日：2011-05-24
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US6066325A
公开(公告)日：2000-05-23
申请号：US32370
申请日：1998-02-27
CPC分类号： A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , Y10S524/916
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
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公开(公告)号：US20120134980A1
公开(公告)日：2012-05-31
申请号：US13174963
申请日：2011-07-01
申请人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
发明人： Donald G. Wallace , Cary J. Reich , Narinder S. Shargill , Felix Vega , A. Edward Osawa , Zhen Qian-Wallis
CPC分类号： A61K38/4833 , A61K9/0002 , A61L2/081 , A61L2/087 , A61L24/0015 , A61L24/0031 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/418 , A61L2300/604 , A61L2400/04
摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.
摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。
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公开(公告)号：US10166142B2
公开(公告)日：2019-01-01
申请号：US14236863
申请日：2012-08-03
申请人： Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
发明人： Eugene De Juan, Jr. , Yair Alster , Kathleen Cogan Farinas , K. Angela MacFarlane , Cary J. Reich , Randolph E. Campbell , Signe Erickson
IPC分类号： A61F9/00 , A61K9/00 , A61K31/382 , A61K31/407 , A61K31/519
摘要： A therapeutic device that can release a therapeutic agent comprising a porous structure coupled to a container comprising a reservoir. The reservoir can comprise a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in a patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
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