公开(公告)号：US10081822B2

公开(公告)日：2018-09-25

申请号：US15573236

申请日：2016-05-10

申请人： CJ Cheiljedang Corporation

发明人： Seok Myung Lee ,  Baek Seok Lee ,  Kyungrim Kim ,  Kwang Ho Lee ,  Keun Cheol Lee ,  Hyeongpyo Hong

IPC分类号： C12N9/16 ,  C12P13/22 ,  C12Q1/68 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04 ,  C12N15/70 ,  C12P13/14

CPC分类号： C12P13/227 ,  C12N1/20 ,  C12N15/70 ,  C12P13/14

摘要： The present invention relates to a microorganism of the genus Escherichia in which L-tryptophan productivity is improved by inactivating phosphatase activity. Further, the present invention relates to a method for producing L-tryptophan using the microorganism of the genus Escherichia.

公开(公告)号：US09758772B2

公开(公告)日：2017-09-12

申请号：US14899676

申请日：2014-04-24

申请人： CJ Cheiljedang Corporation

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Eun Sung Koh ,  Hyung Joon Kim ,  Keun Cheol Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C12P13/02 ,  C12N9/10 ,  C12N1/20 ,  C12P21/06 ,  C12P19/34 ,  C12N15/00 ,  C07H21/04 ,  C07K1/00 ,  C12N9/12 ,  C12N15/70 ,  C07K14/245

CPC分类号： C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

摘要： The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

公开(公告)号：US09587261B2

公开(公告)日：2017-03-07

申请号：US14371465

申请日：2013-01-10

申请人： CJ Cheiljedang Corporation

发明人： Kwang Ho Lee ,  Hye Min Park ,  Hyo Hyoung Lee ,  Young Bin Hwang ,  Seok Myung Lee

IPC分类号： C12P13/22 ,  C12N1/20 ,  C07K14/245 ,  C12N15/71 ,  H01L27/32 ,  H01L51/52

CPC分类号： C12P13/227 ,  C07K14/245 ,  C12N15/71 ,  H01L27/3276 ,  H01L51/5231

摘要： The present invention relates to microorganisms of Escherichia coli having enhanced L-tryptophan productivity and to a method for producing L-tryptophan using the same. More particularly, the present invention relates to an Escherichia coli variant in which repression and attenuation control of the tryptophan operon is released and accumulation of anthranilate is reduced and thereby enhancing L-tryptophan productivity. The present invention also relates to a method for producing L-tryptophan using the Escherichia coli variant.

摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的大肠杆菌的微生物以及使用其的生产L-色氨酸的方法。 更具体地，本发明涉及其中释放色氨酸操纵子的抑制和衰减控制并降低邻氨基苯甲酸盐的积聚并从而提高L-色氨酸生产力的大肠杆菌变体。 本发明还涉及使用大肠杆菌变体产生L-色氨酸的方法。

公开(公告)号：US20150099281A1

公开(公告)日：2015-04-09

申请号：US14367818

申请日：2012-12-21

申请人： CJ CHEILJEDANG CORPORATION

发明人： Kwang Ho Lee ,  Sang Jo Lim ,  Jun Ok Moon ,  Jae Woo Jang ,  Su Jin Park ,  Sang Hee Park

IPC分类号： C12P13/08 ,  C12N9/12 ,  C12N9/00 ,  C12N9/10

CPC分类号： C12P13/08 ,  C12N9/1022 ,  C12N9/1217 ,  C12N9/93 ,  C12N15/52 ,  C12N15/63 ,  C12N15/74 ,  C12Y202/01001 ,  C12Y207/02004 ,  C12Y604/01001 ,  Y02P20/52

摘要： The present invention relates to a modified polynucleotide encoding aspartate kinase (EC:2.7.2.4; hereinafter, referred to as LysC), transketolase (EC:2.2.1.1; hereinafter, referred to as Tkt) or pyruvate carboxylase (EC:6.4.1.1; hereinafter, referred to as Pyc), in which the initiation codon is substituted with ATG, a vector including the same, a microorganism transformed with the vector, and a method for producing L-lysine using the same.

摘要翻译： 本发明涉及编码天冬氨酸激酶（EC：2.7.2.4;以下称为LysC），转酮醇酯酶（EC：2.2.1.1;以下称为Tkt）或丙酮酸羧化酶（EC：6.4.1.1 ;以下称为Pyc），其中起始密码子被ATG取代，含有该起始密码子的载体，用载体转化的微生物和使用其的L-赖氨酸的制备方法。

公开(公告)号：US20140377816A1

公开(公告)日：2014-12-25

申请号：US14371653

申请日：2013-01-10

申请人： CJ CHEILJEDANG CORPORATION

发明人： So Yeon Rah ,  Lan Huh ,  Chang Gyeom Kim ,  Kwang Ho Lee ,  Jun Ok Moon ,  Kyung Han Lee ,  Jin Seok Sung ,  Hyung Joon Kim

IPC分类号： C12P13/08

CPC分类号： C12P13/08 ,  C12N9/1205 ,  C12N9/92 ,  C12Y207/01017 ,  C12Y503/01005 ,  Y02P20/52

摘要： The present invention relates to microorganisms of corynebacterium which can utilize xylose and to a method for producing L-lysine using same. More particularly, the present invention relates to microorganisms of corynebacterium which are modified, in which genes encoding xylose isomerase and xylulokinase which are xylose synthases are introduced to express the xylose synthase. The present invention also relates to a method for producing L-lysine, comprising a step of culturing the modified microorganisms of corynebacterium using xylose as a carbon source, and recovering L-lysine from the culture.

摘要翻译： 本发明涉及能够利用木糖的棒状杆菌的微生物和使用其的L-赖氨酸的制造方法。 更具体地，本发明涉及被修饰的棒状杆菌的微生物，其中引入木糖异构酶和木酮糖激酶的基因是木糖合成酶来表达木糖合酶。 本发明还涉及L-赖氨酸的制造方法，其特征在于，包括使用木糖作为碳源培养棒状杆菌的修饰微生物并从培养物中回收L-赖氨酸的步骤。

公开(公告)号：US11312982B2

公开(公告)日：2022-04-26

申请号：US16930082

申请日：2020-07-15

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C12N15/31 ,  C07K14/245 ,  C12N9/12

摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (δ70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

公开(公告)号：US10760108B2

公开(公告)日：2020-09-01

申请号：US15117437

申请日：2015-09-04

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C07K14/245 ,  C12N1/21 ,  C12N9/12

摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (π70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

公开(公告)号：US20200248218A1

公开(公告)日：2020-08-06

申请号：US15769920

申请日：2016-10-21

申请人： CJ CHEILJEDANG CORPORATION

发明人： Chang Il Seo ,  Hye Min Park ,  Kwang Ho Lee ,  Sang Min Park ,  Kyung Rim Kim ,  Ki Yong Cheong

IPC分类号： C12P13/08 ,  C12N9/88 ,  C12N9/10

摘要： The present disclosure relates to a recombinant microorganism producing threonine, and a method for producing L-threonine using the same.

公开(公告)号：US20180037615A1

公开(公告)日：2018-02-08

申请号：US15508662

申请日：2015-09-04

申请人： CJ CHEILJEDANG CORPORATION

发明人： Lan Huh ,  Kwang Ho Lee ,  Hyung Joon Kim ,  Jun Ok Moon ,  Song-Gi Ryu

IPC分类号： C07K14/34 ,  C12R1/15 ,  C12P13/08

摘要： The present disclosure relates to a novel modified RNA polymerase sigma factor A (SigA) polypeptide; a polynucleotide encoding the same; a microorganism containing the polypeptide; and a method for producing L-lysine using the microorganism.

公开(公告)号：US09777282B2

公开(公告)日：2017-10-03

申请号：US15103147

申请日：2014-12-08

申请人： CJ CHEILJEDANG CORPORATION

发明人： Jun Ok Moon ,  Sang Hee Park ,  Lan Huh ,  Kwang Ho Lee

IPC分类号： C12P13/08 ,  C07K14/34 ,  C12N15/77 ,  C12N1/21 ,  C12R1/15

CPC分类号： C12N15/77 ,  C07K14/34 ,  C12P13/08 ,  C12R1/15

摘要： A microorganism of the genus Corynebacterium with an improved ability to produce L-lysine in which a septum formation initiator protein is inactivated and a method for producing L-lysine using the microorganism.