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公开(公告)号：US11974993B2
公开(公告)日：2024-05-07
申请号：US17677408
申请日：2022-02-22
Applicant: City of Hope
Inventor： Yuelong Ma , Rajiv Nallu , David Horne
IPC: A61K31/4439 , A61K9/08 , A61K47/44
CPC classification number: A61K31/4439 , A61K9/08 , A61K47/44
Abstract: Provided herein are solution formulations of CX-011 and related methods for making solution formulations of CX-011. Also provided are methods of treating an inflammatory disorder, such as osteoarthritis, or cancer in a subject in need thereof by administering an effective amount of the solution formulations of CX-011.
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公开(公告)号：US11246942B2
公开(公告)日：2022-02-15
申请号：US15614468
申请日：2017-06-05
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
IPC: C07K16/18 , C07K16/28 , C07K16/32 , A61K38/08 , A61K39/395 , A61K47/06 , A61K51/10 , B82Y5/00 , A61K38/12 , A61K47/68 , A61K47/66
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US20240199631A1
公开(公告)日：2024-06-20
申请号：US18522750
申请日：2023-11-29
Applicant: City of Hope
Inventor： Jun Xie , Yuelong Ma , David Horne
IPC: C07D491/22 , A61K47/64 , C07K14/765
CPC classification number: C07D491/22 , A61K47/643 , C07K14/765
Abstract: Described herein, inter alia, is a method of conjugating of human serum Albumin (HSA) to SN38.
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公开(公告)号：US20230127630A1
公开(公告)日：2023-04-27
申请号：US17794922
申请日：2021-01-27
Applicant: CITY OF HOPE
Inventor： Jianjun Chen , Hengyou Weng , Huilin Huang , David Horne , Yuelong Ma , Hongzhi Li , Xiaolan Deng
IPC: C07C243/38
Abstract: Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.
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公开(公告)号：US20210023238A1
公开(公告)日：2021-01-28
申请号：US16937483
申请日：2020-07-23
Applicant: City of Hope
Inventor： Dan Raz , David Horne , Keqiang Zhang , Yuelong Ma
Abstract: The antibody-drug conjugates provided herein including embodiments thereof, include the compound triptolide attached to a cancer-specific antibody (e.g., cetuximab) and are, inter alia, useful as highly effective anti-cancer therapeutics. The conjugates provided herein are capable of targeting cancer cells and thereby specifically deliver triptolide to the cancer cell.
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Patent Agency Ranking
公开(公告)号：US20200368364A1
公开(公告)日：2020-11-26
申请号：US16467450
申请日：2017-12-06
Applicant: City of Hope
Inventor： John C. Williams , Krzysztof Bzymek , Yuelong Ma , David Horne , Jeremy King
Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.
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公开(公告)号：US20180193479A1
公开(公告)日：2018-07-12
申请号：US15614468
申请日：2017-06-05
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
CPC classification number: A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US20250066418A1
公开(公告)日：2025-02-27
申请号：US18608790
申请日：2024-03-18
Applicant: City of Hope
Inventor： John C. Williams , Krzysztof Bzymek , Yuelong Ma , David Horne , Jeremy King
Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.
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公开(公告)号：US20230001003A1
公开(公告)日：2023-01-05
申请号：US17556863
申请日：2021-12-20
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua Michael Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra Nicole Avery , Jun Xie
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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公开(公告)号：US09669108B2
公开(公告)日：2017-06-06
申请号：US14453586
申请日：2014-08-06
Applicant: City of Hope
Inventor： John C. Williams , David A. Horne , Yuelong Ma , Heng Wei Chang , Joshua M. Donaldson , Cindy Zer , Krzysztof Bzymek , Kendra N. Avery , Jun Xie
IPC: C07K16/18 , C07K7/00 , A61K47/48 , A61K38/00 , A61K39/00 , A61K51/10 , C07K16/28 , C07K16/32 , B82Y5/00
CPC classification number: A61K47/6811 , A61K47/66 , A61K47/6813 , A61K47/6851 , A61K47/6877 , A61K47/6897 , A61K51/1087 , B82Y5/00 , C07K16/18 , C07K16/2863 , C07K16/32 , C07K2299/00 , C07K2317/34 , C07K2317/40 , C07K2317/55 , C07K2317/567 , C07K2317/622 , C07K2317/92
Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.
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