公开(公告)号：US20180193479A1

公开(公告)日：2018-07-12

申请号：US15614468

申请日：2017-06-05

Applicant: City of Hope

Inventor： John C. Williams ,  David A. Horne ,  Yuelong Ma ,  Heng Wei Chang ,  Joshua Michael Donaldson ,  Cindy Zer ,  Krzysztof Bzymek ,  Kendra Nicole Avery ,  Jun Xie

IPC: A61K47/68 ,  A61K51/10 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/28 ,  C07K16/32

CPC classification number: A61K47/6811 ,  A61K47/66 ,  A61K47/6813 ,  A61K47/6851 ,  A61K47/6877 ,  A61K47/6897 ,  A61K51/1087 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2299/00 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

公开(公告)号：US09828342B2

公开(公告)日：2017-11-28

申请号：US13776374

申请日：2013-02-25

Applicant: CITY OF HOPE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： David A. Horne ,  Richard Jove ,  Christopher Lincoln ,  Sangkil Nam ,  Larry Overman ,  Jun Xie

IPC: C07D209/38 ,  C07D401/10 ,  C07D401/04

CPC classification number: C07D209/38 ,  C07D401/04 ,  C07D401/10

Abstract: One aspect of the invention relates to novel isatin derivative compounds and the pharmaceutical composition thereof. Another aspect of the invention relates to methods of using the isatin derivative compounds disclosed herein and the pharmaceutical compositions thereof. In certain embodiments, the method is used to treat a cancer or a tumor in a subject including, without limitation, prostate cancer, melanoma, pancreatic cancer, ovarian cancer, and lymphoma. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the activation of one or more proteins such as EGFR, Erk1/2, Her2/Neu, Jak2, Src, Stat3, Akt, Cyclin B1, and Cdc25C. In certain embodiment, the method is used to treat a condition in a subject that can be regulated by the disruption of microtubule formations.

公开(公告)号：US20220213489A1

公开(公告)日：2022-07-07

申请号：US17614233

申请日：2020-06-01

Applicant: City of Hope

Inventor： Tongyuan Xue ,  David A. Horne ,  Lihua Elizabeth Budde ,  Steve Forman ,  Marissa M. Del Real

IPC: C12N15/62 ,  C07K14/725

Abstract: Chimeric antigen receptors targeted to CD33 are described together with their use in treating various cancers and in reducing myeloid derived suppressor cells in a patient.

公开(公告)号：US11246942B2

公开(公告)日：2022-02-15

申请号：US15614468

申请日：2017-06-05

Applicant: City of Hope

Inventor： John C. Williams ,  David A. Horne ,  Yuelong Ma ,  Heng Wei Chang ,  Joshua Michael Donaldson ,  Cindy Zer ,  Krzysztof Bzymek ,  Kendra Nicole Avery ,  Jun Xie

IPC: C07K16/18 ,  C07K16/28 ,  C07K16/32 ,  A61K38/08 ,  A61K39/395 ,  A61K47/06 ,  A61K51/10 ,  B82Y5/00 ,  A61K38/12 ,  A61K47/68 ,  A61K47/66

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

公开(公告)号：US20230001003A1

公开(公告)日：2023-01-05

申请号：US17556863

申请日：2021-12-20

Applicant: City of Hope

Inventor： John C. Williams ,  David A. Horne ,  Yuelong Ma ,  Heng Wei Chang ,  Joshua Michael Donaldson ,  Cindy Zer ,  Krzysztof Bzymek ,  Kendra Nicole Avery ,  Jun Xie

IPC: A61K47/68 ,  C07K16/28 ,  C07K16/32 ,  B82Y5/00 ,  A61K47/66 ,  A61K51/10 ,  C07K16/18

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.

公开(公告)号：US09669108B2

公开(公告)日：2017-06-06

申请号：US14453586

申请日：2014-08-06

Applicant: City of Hope

Inventor： John C. Williams ,  David A. Horne ,  Yuelong Ma ,  Heng Wei Chang ,  Joshua M. Donaldson ,  Cindy Zer ,  Krzysztof Bzymek ,  Kendra N. Avery ,  Jun Xie

IPC: C07K16/18 ,  C07K7/00 ,  A61K47/48 ,  A61K38/00 ,  A61K39/00 ,  A61K51/10 ,  C07K16/28 ,  C07K16/32 ,  B82Y5/00

CPC classification number: A61K47/6811 ,  A61K47/66 ,  A61K47/6813 ,  A61K47/6851 ,  A61K47/6877 ,  A61K47/6897 ,  A61K51/1087 ,  B82Y5/00 ,  C07K16/18 ,  C07K16/2863 ,  C07K16/32 ,  C07K2299/00 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/92

Abstract: Antibodies and meditopes that bind to the antibodies are provided, as well as complexes, compositions and combinations containing the meditopes and antibodies, and methods of producing, using, testing, and screening the same, including therapeutic and diagnostic methods and uses.