公开(公告)号：US20220213489A1

公开(公告)日：2022-07-07

申请号：US17614233

申请日：2020-06-01

Applicant: City of Hope

Inventor： Tongyuan Xue ,  David A. Horne ,  Lihua Elizabeth Budde ,  Steve Forman ,  Marissa M. Del Real

IPC: C12N15/62 ,  C07K14/725

Abstract: Chimeric antigen receptors targeted to CD33 are described together with their use in treating various cancers and in reducing myeloid derived suppressor cells in a patient.

公开(公告)号：US20220249560A1

公开(公告)日：2022-08-11

申请号：US17612794

申请日：2020-05-22

Applicant: City of Hope

Inventor： Lihua Elizabeth Budde ,  Marissa M. Del Real ,  Stephen Forman

IPC: A61K35/17 ,  C07K14/725 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783

Abstract: Chimeric antigen receptors for use in treating lymphoma-associated C-C chemokine receptor type 4 (CCR4) and other cancers expressing CCR4 are described.