公开(公告)号：US20220370434A1

公开(公告)日：2022-11-24

申请号：US17627059

申请日：2020-07-23

Applicant: City of Hope

Inventor： Jianjun Chen ,  Rui Su ,  David Horne ,  Xiaolan Deng ,  Hongzhi Li ,  Jun Xie

IPC: A61K31/47 ,  A61P35/02 ,  A61K31/4178 ,  A61K31/7068 ,  A61K31/704 ,  A61K31/495 ,  A61K45/06 ,  C07D233/52 ,  C07D403/14 ,  C07D215/52 ,  C07D219/04 ,  A61K31/497 ,  A61K31/473

Abstract: Provided, inter alia, are methods and compositions for treating FTO-mediated cancer.

公开(公告)号：US20230127630A1

公开(公告)日：2023-04-27

申请号：US17794922

申请日：2021-01-27

Applicant: CITY OF HOPE

Inventor： Jianjun Chen ,  Hengyou Weng ,  Huilin Huang ,  David Horne ,  Yuelong Ma ,  Hongzhi Li ,  Xiaolan Deng

IPC: C07C243/38

Abstract: Described herein, inter alia, are IGF2BP2 inhibitor compounds and methods of using the same.

公开(公告)号：US20220339155A1

公开(公告)日：2022-10-27

申请号：US17632963

申请日：2020-08-20

Applicant: City of Hope

Inventor： Jianjun Chen ,  Xiaolan Deng ,  Li Han ,  Hongzhi Li ,  Rui Su

IPC: A61K31/519

Abstract: The disclosure provides, inter alia, METTL16 inhibitors and methods of treating cancers that overexpress METTL16.