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    SYSTEMS AND METHODS FOR WRITING BY SEQUENCING OF NUCLEIC ACIDS
    2.
    发明公开
    SYSTEMS AND METHODS FOR WRITING BY SEQUENCING OF NUCLEIC ACIDS 审中-公开

    公开(公告)号：US20230317164A1

    公开(公告)日：2023-10-05

    申请号：US18024909

    申请日：2021-09-07

    Applicant: CATALOG TECHNOLOGIES, INC.

    Inventor： Nathaniel Roquet ,  Swapnil P. Bhatia ,  Devin Leake

    IPC: G11C13/02 ,  C12Q1/6855 ,  C12Q1/6869 ,  G16B50/30 ,  G06N3/123

    CPC classification number: G11C13/02 ,  C12Q1/6855 ,  C12Q1/6869 ,  G16B50/30 ,  G06N3/123

    Abstract: The systems, devices, and methods described herein provide nucleic acid digital data storage encoding and retrieving methods that are less costly and easier to commercially implement than existing methods. The systems, devices, and methods described herein provide scalable methods for writing data to and reading data from nucleic acid molecules. The present disclosure covers five primary areas of interest: (1) writing digital information into nucleic acid molecules, (2) accurately and quickly reading information stored in nucleic acid molecules, (3) partitioning data to efficiently encode data in nucleic acid molecules, (4) error protection and correction when encoding data in nucleic acid molecules, and (5) data structures to provide efficient access to information stored in nucleic acid molecules.

    PROGRAMS AND FUNCTIONS IN DNA-BASED DATA STORAGE
    3.
    发明申请
    PROGRAMS AND FUNCTIONS IN DNA-BASED DATA STORAGE 有权

    公开(公告)号：US20230036568A1

    公开(公告)日：2023-02-02

    申请号：US17693705

    申请日：2022-03-14

    Applicant: CATALOG TECHNOLOGIES, INC.

    Inventor： Nathaniel Roquet ,  Swapnil P. Bhatia ,  Michael Norsworthy ,  Sarah Flickinger ,  Tracy Kambara

    IPC: C12Q1/686 ,  G16B30/00 ,  C12Q1/6813 ,  G06N3/12

    Abstract: Systems and methods are provided herein for encoding and storing information in nucleic acids. Encoded information is partitioned and stored in nucleic acids having native key-value pairs that allow for storage of metadata or other data objects. Computation on the encoded information is performed by chemical implementation of if-then-else operations. Numerical data is stored in nucleic acids by producing samples having nucleic acid sequences copy counts corresponding to the numerical data. Data objects of a dataset are encoded by partitioning of bytes into parts and encoding of parts along distinct libraries of nucleic acids. These libraries can be used as inputs for computation on the dataset.

    PRINTER-FINISHER SYSTEM FOR DATA STORAGE IN DNA
    4.
    发明申请
    PRINTER-FINISHER SYSTEM FOR DATA STORAGE IN DNA 审中-公开

    公开(公告)号：US20190351673A1

    公开(公告)日：2019-11-21

    申请号：US16414752

    申请日：2019-05-16

    Applicant: Catalog Technologies, Inc.

    Inventor： Nathaniel Roquet ,  Hyunjun Park ,  Swapnil P. Bhatia ,  Mike Hazel ,  Richard Day ,  Richard Hammond ,  James Brown ,  Rodney Richardson ,  Thomas Redman ,  Devin Leake

    IPC: B41J2/045 ,  C12P19/34 ,  G06N3/12 ,  B41J2/165 ,  B41J2/05

    Abstract: Provided herein are systems and methods for storing digital information by assembling an identifier nucleic acid molecule from at least a first component nucleic acid molecule and a second component nucleic acid molecule. The system may include a first printhead configured to dispense a first droplet of a first solution comprising the first component nucleic acid molecule onto a coordinate on a substrate, and a second printhead configured to dispense a second droplet of a second solution comprising the second component nucleic acid molecule onto the coordinate on the substrate, such that the first and second component nucleic acid molecules are collocated on the substrate. The system may include a finisher that dispenses a reaction mix onto the coordinate on the substrate to physically link the first and second component nucleic acid molecules, provides a condition necessary to physically link the first and second component nucleic acid molecules, or both.

    NUCLEIC ACID-BASED DATA STORAGE
    7.
    发明公开
    NUCLEIC ACID-BASED DATA STORAGE 审中-公开

    公开(公告)号：US20230376788A1

    公开(公告)日：2023-11-23

    申请号：US18230385

    申请日：2023-08-04

    Applicant: Catalog Technologies, Inc.

    Inventor： Nathaniel Roquet ,  Hyunjun Park ,  Swapnil P. Bhatia

    IPC: G06N3/123 ,  G06F5/08 ,  C12N9/22

    CPC classification number: G06N3/123 ,  G06F5/08 ,  C12N9/22 ,  C12N2310/20 ,  G16B20/00

    Abstract: Methods and systems for encoding digital information in nucleic acid (e.g., deoxyribonucleic acid) molecules without base-by-base synthesis, by encoding bit-value information in the presence or absence of unique nucleic acid sequences within a pool, comprising specifying each bit location in a bit-stream with a unique nucleic sequence and specifying the bit value at that location by the presence or absence of the corresponding unique nucleic acid sequence in the pool. But, more generally, specifying unique bytes in a bytestream by unique subsets of nucleic acid sequences. Also disclosed are methods for generating unique nucleic acid sequences without base-by-base synthesis using combinatorial genomic strategies (e.g., assembly of multiple nucleic acid sequences or enzymatic-based editing of nucleic acid sequences).

    Nucleic acid security and authentication
    8.
    发明授权
    Nucleic acid security and authentication 有权

    公开(公告)号：US11535842B2

    公开(公告)日：2022-12-27

    申请号：US17069420

    申请日：2020-10-13

    Applicant: CATALOG TECHNOLOGIES, INC.

    Inventor： Nathaniel Roquet ,  Hyunjun Park ,  Swapnil P. Bhatia ,  Devin Leake

    IPC: C12N15/10 ,  G06N3/00 ,  G06N3/12 ,  H04L9/08 ,  H04L9/32

    Abstract: Methods and systems for security, authentication, tagging, and tracking using nucleic acid (e.g., deoxyribonucleic acid) molecules encoding information. Unique nucleic acid molecules are efficiently produced from pre-fabricated fragments to quickly produce libraries of nucleic acid molecules encoding encrypted or randomized information. Physical objects or artifacts can be tagged with libraries to authenticate the objects, grant access to secured assets or locations, or track the objects or entities. Chemical methods can be applied to verify authenticity, decrypt, or decode information stored in the libraries.

    PROGRAMS AND FUNCTIONS IN DNA-BASED DATA STORAGE
    9.
    发明申请
    PROGRAMS AND FUNCTIONS IN DNA-BASED DATA STORAGE 有权

    公开(公告)号：US20210348214A1

    公开(公告)日：2021-11-11

    申请号：US17317547

    申请日：2021-05-11

    Applicant: CATALOG TECHNOLOGIES, INC.

    Inventor： Nathaniel Roquet ,  Swapnil P. Bhatia ,  Michael Norsworthy ,  Sarah Flickinger ,  Tracy Kambara

    IPC: C12Q1/686 ,  C12Q1/6813

    Abstract: Systems and methods are provided herein for encoding and storing information in nucleic acids. Encoded information is partitioned and stored in nucleic acids having native key-value pairs that allow for storage of metadata or other data objects. Computation on the encoded information is performed by chemical implementation of if-then-else operations. Numerical data is stored in nucleic acids by producing samples having nucleic acid sequences copy counts corresponding to the numerical data. Data objects of a dataset are encoded by partitioning of bytes into parts and encoding of parts along distinct libraries of nucleic acids. These libraries can be used as inputs for computation on the dataset.

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