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公开(公告)号:US20220305237A1
公开(公告)日:2022-09-29
申请号:US17831189
申请日:2022-06-02
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
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公开(公告)号:US09517199B2
公开(公告)日:2016-12-13
申请号:US14630305
申请日:2015-02-24
申请人: BioCardia, Inc.
发明人: Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
CPC分类号: A61K9/0019 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/35
摘要: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
摘要翻译: 一种治疗慢性心肌梗塞的方法,包括在慢性心肌梗死(MI)患者中,在低或运动不全的区域周围的自体骨髓(ABM)单核细胞的螺旋针经心内传递。 治疗是安全的并且改善射血分数(EF)。
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公开(公告)号:US20150231368A1
公开(公告)日:2015-08-20
申请号:US14501635
申请日:2014-09-30
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
CPC分类号: A61M25/0084 , A61B2017/00247 , A61B2090/036 , A61M2025/0089
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
摘要翻译: 针注射导管包括具有远端,近端,刚性近端部分,柔性远端部分和延伸通过其的输送腔的导管体。 在第一实施例中,直注射针从导管主体的柔性部分的远侧末端同轴延伸,以及多个穿透限制元件,其围绕直线注射针的基部周向定位,并被构造成径向向内折叠抵靠轴 当被限制在管状内腔中并且当不受约束时径向向外延伸。 在第二实施例中,螺旋针从导管主体的柔性部分的远端延伸。 螺旋针具有至少一个螺旋输送腔,其连接以从导管体的输送腔接收可注射物质。
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公开(公告)号:US11986611B2
公开(公告)日:2024-05-21
申请号:US17010603
申请日:2020-09-02
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
CPC分类号: A61M25/0606 , A61M25/0084 , A61M25/09 , A61B2017/00247 , A61B2090/036 , A61M2025/0089 , A61M2025/09166 , A61M2025/09175 , A61M2025/09191
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
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公开(公告)号:US10780248B2
公开(公告)日:2020-09-22
申请号:US16059480
申请日:2018-08-09
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
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公开(公告)号:US20180344986A1
公开(公告)日:2018-12-06
申请号:US16059480
申请日:2018-08-09
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
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公开(公告)号:US10071226B2
公开(公告)日:2018-09-11
申请号:US14501635
申请日:2014-09-30
申请人: BioCardia, Inc.
发明人: Wai Hsueh , Olin Jay Palmer , Scott Comiso , James B. Ross , Ken Vien , Julio Argentieri , Peter Altman
CPC分类号: A61M25/0606 , A61B2017/00247 , A61B2090/036 , A61M25/0084 , A61M25/09 , A61M2025/0089 , A61M2025/09166 , A61M2025/09175 , A61M2025/09191
摘要: A needle-injection catheter includes a catheter body having a distal end, a proximal end, a stiff proximal portion, a flexible distal portion, and a delivery lumen extending therethrough. In a first embodiment, a straight injection needle extends coaxially from a distal tip of the flexible portion of the catheter body, and a plurality of penetration limiting elements positioned circumferentially about a base of the straight injection needle and configured to fold radially inwardly against a shaft of the needle when constrained in a tubular lumen and to extend radially outwardly when unconstrained. In a second embodiment, a helical needle extends from the distal tip of the flexible portion of the catheter body. The helical needle has at least one helical delivery lumen connected to receive an injectable substance from the delivery lumen of the catheter body.
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公开(公告)号:US20170266107A1
公开(公告)日:2017-09-21
申请号:US15341471
申请日:2016-11-02
申请人: BioCardia, Inc.
发明人: Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
CPC分类号: A61K9/0019 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/35
摘要: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
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公开(公告)号:US09504642B2
公开(公告)日:2016-11-29
申请号:US13953961
申请日:2013-07-30
申请人: BioCardia, Inc.
发明人: Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
CPC分类号: A61K9/0019 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/35
摘要: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
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公开(公告)号:US20150164786A1
公开(公告)日:2015-06-18
申请号:US14630305
申请日:2015-02-24
申请人: BioCardia, Inc.
发明人: Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
CPC分类号: A61K9/0019 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/35
摘要: A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
摘要翻译: 一种治疗慢性心肌梗塞的方法,包括在慢性心肌梗死(MI)患者中,在低或运动不全的区域周围的自体骨髓(ABM)单核细胞的螺旋针经心内传递。 治疗是安全的并且改善射血分数(EF)。
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