-
公开(公告)号：US20180169657A1
公开(公告)日：2018-06-21
申请号：US15897022
申请日：2018-02-14
Applicant: Battelle Memorial Institute
Inventor： Ryan T. Kelly , Ying Zhu , Richard D. Smith
CPC classification number: B01L3/502753 , C12M23/58 , C12M41/00 , C12Q1/6881 , C40B60/04 , G01N1/2813 , G01N30/88 , G01N33/4833 , G01N2001/284 , G01N2030/8831
Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.
-
公开(公告)号：US20140291155A1
公开(公告)日：2014-10-02
申请号：US14264385
申请日：2014-04-29
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Ryan T. Kelly , Keqi Tang
IPC: G01N27/447
CPC classification number: G01N27/44743 , B01D19/0031 , B01L3/502738 , B01L2300/0816 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , B01L2400/0655 , G01N27/44791 , G01N30/461
Abstract: Microfluidic sample injection, which is based on a mechanical valve rather than electrokinetic injection into an integrated separation channel or a discrete separation column, can provide improved sample injections, enhanced capabilities, and can eliminate the need for changing the electric field in the separation channel to induce sample injection. An interface allowing the use of a discrete separation column easily allows for flexibility to utilize the microfluidic injector with existing analytical techniques. Multiple sample channels and/or sample sources can be utilized with the microfluidic sample injector.
Abstract translation: 基于机械阀而不是电动注入集成分离通道或离散分离柱的微流体样品注入可以提供改进的样品注入，增强的能力，并且可以消除将分离通道中的电场改变为 诱导注射样品。 允许使用离散分离柱的界面容易允许利用现有分析技术利用微流体注射器的灵活性。 多个样品通道和/或样品源可以与微流体样品注射器一起使用。
-
公开(公告)号：US12005452B2
公开(公告)日：2024-06-11
申请号：US17404478
申请日：2021-08-17
Applicant: Battelle Memorial Institute
Inventor： Ryan T. Kelly , Ying Zhu , Richard D. Smith
IPC: B01L3/00 , A61B10/02 , B01J19/00 , C12M1/00 , C12M1/34 , C12Q1/6881 , C40B60/04 , G01N1/28 , G01N1/30 , G01N1/34 , G01N30/88 , G01N33/483 , G01N33/68 , G02B21/32
CPC classification number: B01L3/502753 , A61B10/02 , B01J19/0046 , B01L3/00 , B01L3/50853 , B01L3/5088 , C12M23/58 , C12M41/00 , C12Q1/6881 , C40B60/04 , G01N1/2813 , G01N1/30 , G01N1/34 , G01N30/88 , G01N33/4833 , G01N33/68 , G02B21/32 , B01J2219/00317 , B01J2219/00367 , B01J2219/00619 , B01J2219/00621 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/00743 , B01L2200/142 , B01L2300/0819 , B01L2300/0822 , B01L2300/0887 , G01N2001/284 , G01N2030/8831
Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.
-
Patent Agency Ranking
公开(公告)号：US11123732B2
公开(公告)日：2021-09-21
申请号：US15897022
申请日：2018-02-14
Applicant: Battelle Memorial Institute
Inventor： Ryan T. Kelly , Ying Zhu , Richard D. Smith
IPC: B01L3/00 , G01N1/28 , G01N30/88 , C12M1/34 , C40B60/04 , C12M1/00 , A61B10/02 , G01N1/34 , C12Q1/6881 , G01N1/30 , G02B21/32 , B01J19/00 , G01N33/483 , G01N33/68
Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.
-
公开(公告)号：US20180299463A1
公开(公告)日：2018-10-18
申请号：US15993949
申请日：2018-05-31
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Paul D. Piehowski , Ying Zhu , Ryan T. Kelly , Kristin E. Burnum-Johnson , Ronald J. Moore
Abstract: Provided herein are methods and systems for proteome analysis that are at least partially automated and/or performed robotically. In some aspects, the methods and systems described herein can rapidly and efficiently provide protein identification of each of the proteins from a proteome, or a complement of proteins, obtained from extremely small amounts of biological samples. The identified proteins can be imaged quantitatively over a spatial region. Automation and robotics facilitates the throughput of the methods and systems, which enables protein imaging and/or rapid proteome analysis.
-
公开(公告)号：US20230341409A1
公开(公告)日：2023-10-26
申请号：US18209858
申请日：2023-06-14
Applicant: Battelle Memorial Institute
Inventor： Paul D. Piehowski , Ying Zhu , Ryan T. Kelly , Kristin E. Burnum-Johnson , Ronald J. Moore
CPC classification number: G01N33/6842 , G01N33/6848 , G16B45/00 , G01N2570/00 , G01N2333/4716
Abstract: Provided herein are methods and systems for proteome analysis that are at least partially automated and/or performed robotically. In some aspects, the methods and systems described herein can rapidly and efficiently provide protein identification of each of the proteins from a proteome, or a complement of proteins, obtained from extremely small amounts of biological samples. The identified proteins can be imaged quantitatively over a spatial region. Automation and robotics facilitates the throughput of the methods and systems, which enables protein imaging and/or rapid proteome analysis.
-
公开(公告)号：US11719702B2
公开(公告)日：2023-08-08
申请号：US15993949
申请日：2018-05-31
Applicant: BATTELLE MEMORIAL INSTITUTE
Inventor： Paul D. Piehowski , Ying Zhu , Ryan T. Kelly , Kristin E. Burnum-Johnson , Ronald J. Moore
CPC classification number: G01N33/6842 , G01N33/6848 , G16B45/00 , G01N2333/4716 , G01N2570/00
Abstract: Provided herein are methods and systems for proteome analysis that are at least partially automated and/or performed robotically. In some aspects, the methods and systems described herein can rapidly and efficiently provide protein identification of each of the proteins from a proteome, or a complement of proteins, obtained from extremely small amounts of biological samples. The identified proteins can be imaged quantitatively over a spatial region. Automation and robotics facilitates the throughput of the methods and systems, which enables protein imaging and/or rapid proteome analysis.
-
公开(公告)号：US20220080420A1
公开(公告)日：2022-03-17
申请号：US17404478
申请日：2021-08-17
Applicant: Battelle Memorial Institute
Inventor： Ryan T. Kelly , Ying Zhu , Richard D. Smith
IPC: B01L3/00 , G01N1/28 , G01N30/88 , C12M1/34 , C40B60/04 , C12M1/00 , A61B10/02 , G01N1/34 , C12Q1/6881 , G01N1/30 , G02B21/32 , B01J19/00 , G01N33/483 , G01N33/68
Abstract: Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.015 seconds)
