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公开(公告)号：US09492460B2
公开(公告)日：2016-11-15
申请号：US14190477
申请日：2014-02-26
发明人： Michael A. Poss , David R. Tortolani , Dharmpal S. Dodd , Christopher P. Mussari , John S. Tokarski , Ashvinikumar V. Gavai , Yufen Zhao , George V. Delucca , Daniel O'Malley , Derek J. Norris , Patrice Gill , Claude A. Quesnelle , Wen-Ching Han
IPC分类号： C07D405/14 , C07D413/14 , C07D417/14 , A61K31/553 , C07D413/04 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541
CPC分类号： A61K31/553 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20230098244A1
公开(公告)日：2023-03-30
申请号：US17699944
申请日：2022-03-21
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tsair Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US11739098B2
公开(公告)日：2023-08-29
申请号：US17699944
申请日：2022-03-21
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tasir Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D498/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D513/04
摘要： Disclosed are compounds of Formula (I)
or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.-
公开(公告)号：US11306092B2
公开(公告)日：2022-04-19
申请号：US16955166
申请日：2018-12-19
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , David R. Tortolani , Tasir Shamsul Haque , Shoshana L. Posy
IPC分类号： C07D401/04 , A61K31/4439 , C07D471/10 , C07D209/12 , C07D401/14 , C07D403/04 , C07D409/14 , C07D413/12 , C07D471/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US10053454B2
公开(公告)日：2018-08-21
申请号：US14770230
申请日：2014-02-27
发明人： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号： C07D413/04 , C07D413/10 , C07D413/14 , C07D417/14 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using the compositions in the treatment of various disorders.
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公开(公告)号：US20140256700A1
公开(公告)日：2014-09-11
申请号：US14190477
申请日：2014-02-26
发明人： Michael A. Poss , David R. Tortolani , Dharmpal S. Dodd , Christopher P. Mussari , John S. Tokarski , Ashvinikumar V. Gavai , Yufen Zhao , George V. Delucca , Daniel O'Malley , Derek J. Norris , Patrice Gill , Claude A. Quesnelle , Wen-Ching Han
IPC分类号： A61K31/553 , A61K31/5377 , C07D417/14 , C07D413/14 , A61K31/422 , A61K31/4192 , A61K31/496 , A61K31/427 , A61K31/5355 , A61K31/541 , C07D405/14 , C07D413/04 , A61K31/454
CPC分类号： A61K31/553 , A61K31/4192 , A61K31/422 , A61K31/427 , A61K31/454 , A61K31/496 , A61K31/5355 , A61K31/5377 , A61K31/541 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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公开(公告)号：US20210253593A1
公开(公告)日：2021-08-19
申请号：US16763670
申请日：2018-11-13
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , Trevor C. Sherwood , John L. Gilmore , Tasir Shamsul Haque , Brian K. Whiteley , David R. Tortolani , Shoshana L. Posy , John E. Macor , Louis J. Lombardo , Ramesh Kumar Sistla , Anupama Kandhi Ramachandra Reddy , Subramanya Hegde , Laxman Pasunoori , Sreekantha Ratna Kumar
IPC分类号： C07D498/04 , C07D413/14 , C07D471/04 , C07D487/04 , C07D417/14 , C07D405/14 , C07D513/04 , C07D401/14 , C07D495/04
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20200339581A1
公开(公告)日：2020-10-29
申请号：US16955166
申请日：2018-12-19
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Christopher P. Mussari , David R. Tortolani , Tasir Shamsul Haque , Shoshana L. Posy
IPC分类号： C07D471/10 , C07D401/14 , C07D403/04 , C07D471/04 , C07D209/12 , C07D413/12 , C07D409/14
摘要： Disclosed are compounds of Formula (I) or salts thereof, wherein G, R1, R5, R7, R8, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20190262311A1
公开(公告)日：2019-08-29
申请号：US16330964
申请日：2017-09-08
发明人： Alaric J. Dyckman , Dharmpal S. Dodd , Tasir Shamsul Haque , Louis J. Lombardo , John E. Macor , Christopher P. Mussari , Laxman Pasunoori , Michael A. Poss , Sreekantha Ratna Kumar , Shoshana L. Posy , David R. Tortolani , Brian K. Whiteley , Ramesh Kumar Sistla , Subramanya Hegde , Anupama Kandhi Ramachandra Reddy
IPC分类号： A61K31/404 , A61P37/06 , A61P29/00 , A61K9/00
摘要： Disclosed are compounds of Formula (I) N-oxide, or salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
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公开(公告)号：US20160009701A1
公开(公告)日：2016-01-14
申请号：US14770230
申请日：2014-02-27
发明人： Michael A. Poss , David R. Tortolani , Ashok Vinayak Purandare , John S. Tokarski , Christopher P. Mussari , Muthoni G. Kamau , Dharmpal S. Dodd , Ashvinikumar V. Gavai , Daniel O'Malley , Tram N. Huynh , Wayne Vaccaro , Lalgudi S. Harikrishnan
IPC分类号： C07D413/10 , A61K31/5377 , C07D413/14 , A61K31/422 , A61K31/5355 , A61K31/553 , C07D417/14 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/541
CPC分类号： C07D413/10 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5355 , A61K31/5377 , A61K31/541 , A61K31/553 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention is directed to carbazole compounds, pharmaceutically acceptable compositions comprising compounds of the invention and methods of using said compositions in the treatment of various disorders.
摘要翻译： 本发明涉及咔唑化合物，包含本发明化合物的药学上可接受的组合物和使用所述组合物治疗各种疾病的方法。
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