公开(公告)号：US20250066344A1

公开(公告)日：2025-02-27

申请号：US18718477

申请日：2022-12-14

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Sreekantha Ratna Kumar ,  Pitani Veera Venkata Srinivas ,  Subramanya Hegde ,  Michael J. Orwat

IPC: C07D417/12 ,  A61K31/357 ,  A61K31/397 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/422 ,  A61K31/423 ,  A61K31/424 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/437 ,  A61K31/438 ,  A61K31/443 ,  A61K31/4525 ,  A61K31/4725 ,  A61K31/4985 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/675 ,  C07D261/20 ,  C07D317/48 ,  C07D405/12 ,  C07D413/12 ,  C07D413/14 ,  C07D487/04 ,  C07D491/107 ,  C07D495/04 ,  C07D495/10 ,  C07D498/04 ,  C07D498/10 ,  C07D513/04 ,  C07F9/6558

Abstract: The disclosure relates to compounds of Formula (I), which are RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension).

公开(公告)号：US20250011288A1

公开(公告)日：2025-01-09

申请号：US18701270

申请日：2022-10-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Adam James Clarke ,  Todd J. Friends ,  Arvind Mathur ,  Michael C. Myers ,  Jianqing Li ,  Donald J. P. Pinto ,  Kumar Balashanmuga Pabbisetty ,  Shun Su ,  Benjamin P. Vokits ,  Durga Buchi Raju Barre ,  Leon M. Smith, II ,  Michael J. Orwat ,  Scott A. Shaw ,  Sreekantha Ratna Kumar ,  Hima Kiran Potturi

IPC: C07D213/82 ,  A61K31/343 ,  A61K31/353 ,  A61K31/381 ,  A61K31/415 ,  A61K31/416 ,  A61K31/42 ,  A61K31/423 ,  A61K31/424 ,  A61K31/437 ,  A61K31/44 ,  A61K31/4412 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/47 ,  A61K31/4704 ,  A61K31/496 ,  A61K31/4965 ,  A61K31/50 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/541 ,  C07D215/54 ,  C07D217/02 ,  C07D217/04 ,  C07D217/08 ,  C07D231/18 ,  C07D231/22 ,  C07D231/54 ,  C07D237/24 ,  C07D239/34 ,  C07D241/24 ,  C07D261/04 ,  C07D307/00 ,  C07D311/24 ,  C07D333/38 ,  C07D401/06 ,  C07D405/12 ,  C07D413/04 ,  C07D417/14 ,  C07D471/04 ,  C07D491/107 ,  C07D498/04

Abstract: The disclosure relates to compounds of Formula (I), which arm RXFP1 receptor agonists, compositions containing them, and methods of using them, for example, in the treatment of heart failure, fibrotic diseases, and related diseases such as lung disease (e.g., idiopathic pulmonary fibrosis), kidney disease (e.g., chronic kidney disease), or hepatic disease (e.g., non-alcoholic steatohepatitis and portal hypertension). Formula (I)

公开(公告)号：US20240124489A1

公开(公告)日：2024-04-18

申请号：US17766198

申请日：2020-09-30

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Sreekantha Ratna Kumar ,  Lazman Pasunoori ,  Subramanya Hegde ,  Anupama Kandhi ,  Durga Buchi Paju Barre ,  Alaric J. Dyckman

IPC: C07D513/04 ,  C07D519/00

CPC classification number: C07D513/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X, Y, A, G, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11878975B2

公开(公告)日：2024-01-23

申请号：US16955097

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  John L. Gilmore ,  Tasir Shamsul Haque ,  Trevor C. Sherwood ,  Brian K. Whiteley ,  Shoshana L. Posy ,  Sreekantha Ratna Kumar ,  Laxman Pasunoori ,  Srinivasan Kunchithapatham Duraisamy ,  Subramanya Hegde ,  Rushith Kumar Anumula ,  Pitani Veera Venkata Srinivas

IPC: C07D471/08 ,  C07D487/08 ,  C07D519/00 ,  C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

CPC classification number: C07D471/04 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D453/02 ,  C07D487/04 ,  C07D491/08

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20220289739A1

公开(公告)日：2022-09-15

申请号：US17609443

申请日：2020-05-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. DYCKMAN ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar ,  Srinivasan Kunchithaptham Duraisamy ,  Pitani Veera Venkata Srinivas ,  Vikram Bhogadi ,  Subramanya Hegde

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US11427580B2

公开(公告)日：2022-08-30

申请号：US16955089

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Sreekantha Ratna Kumar ,  Durga Buchi Raju Barre ,  Srinivasan Kunchithapatham Duraisamy

IPC: C07D471/04 ,  C07D519/00

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein A, G, R1, R5, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20200308195A1

公开(公告)日：2020-10-01

申请号：US16955108

申请日：2018-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Brian K. Whiteley ,  Sreekantha Ratna Kumar ,  Anupama Kandhi Ramachandra Reddy

IPC: C07D519/00 ,  C07D487/04

Abstract: Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein G, A, X, Y, Z, R1, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

公开(公告)号：US20180072712A1

公开(公告)日：2018-03-15

申请号：US15818826

申请日：2017-11-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D487/04 ,  C07D471/04 ,  C07D413/14 ,  C07D417/04 ,  C07D413/04

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds having the following formula: or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, wherein X is N or C—R7, are useful as kinase modulators, including IRAK-4 modulation.

公开(公告)号：US09242975B2

公开(公告)日：2016-01-26

申请号：US14371456

申请日：2013-01-11

Applicant: Bristol-Myers Squibb Company

Inventor： Venkatram Reddy Paidi ,  Sreekantha Ratna Kumar ,  Abhisek Banerjee ,  Ramesh Sistla ,  Satheesh Kesavan Nair ,  William J. Pitts ,  John Hynes

IPC: C07D417/14 ,  C07D413/14 ,  C07D413/04 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

CPC classification number: C07D417/14 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/10 ,  C07D487/04

Abstract: Compounds having the following formula: wherein A is, or; and X is N or C—R7, or an enantiomer, diastereomer or a pharmaceutically-acceptable salt thereof, are useful as kinase modulators, including IRAK-4 modulation.

Abstract translation: 具有下式的化合物：其中A是或; 并且X是N或C-R7，或其对映体，非对映体或其药学上可接受的盐，可用作激酶调节剂，包括IRAK-4调节。

公开(公告)号：US11739098B2

公开(公告)日：2023-08-29

申请号：US17699944

申请日：2022-03-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Alaric J. Dyckman ,  Dharmpal S. Dodd ,  Christopher P. Mussari ,  Trevor C. Sherwood ,  John L. Gilmore ,  Tasir Shamsul Haque ,  Brian K. Whiteley ,  David R. Tortolani ,  Shoshana L. Posy ,  John E. Macor ,  Louis J. Lombardo ,  Ramesh Kumar Sistla ,  Anupama Kandhi Ramachandra Reddy ,  Subramanya Hegde ,  Laxman Pasunoori ,  Sreekantha Ratna Kumar

IPC: C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04 ,  C07D513/04

CPC classification number: C07D498/04 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D513/04

Abstract: Disclosed are compounds of Formula (I)




or salts thereof, wherein Ring Het, R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.